Coverart for item
The Resource Adverse drug reactions, Jack Uetrecht, editor, (electronic book)

Adverse drug reactions, Jack Uetrecht, editor, (electronic book)

Label
Adverse drug reactions
Title
Adverse drug reactions
Statement of responsibility
Jack Uetrecht, editor
Contributor
Editor
Subject
Language
eng
Summary
This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of what are presently believed to be mediators and biochemical pathways involved in idiosyncratic drug reactions. There is also a description of several examples of ADRs that serve to illustrate specific aspects of ADR mechanisms. Eventually the book shows that ultimately better methods are needed to predict which drug candidates are likely to cause ADRs and which patients are at increased risk. But at present research seems to be far from this goal
Member of
Cataloging source
HNK
Dewey number
615.704
Illustrations
illustrations
Index
index present
LC call number
RM302.5
LC item number
.U48 2010eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Uetrecht, Jack P.
http://library.link/vocab/subjectName
  • Drugs
  • Drug Toxicity
Label
Adverse drug reactions, Jack Uetrecht, editor, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Target organ toxicity. Drug-induced liver injury / Michael Holt, Cynthia Ju -- Drug herpersensitivity reactions involving skin / Oliver Hausmann, Benno Schnyder, Werner J. Pichler -- Adverse drug reactions affecting blood cells / Richard H. Aster -- Molecular mechanisms of adverse drug reactions in cardiac tissue / Reza Tabrizchi -- Mechanisms of drug-induced nephrotoxicity / Thomas D. Nolin, Jonathan Himmelfarb -- Receptor- and reactive intermediate-mediated mechanisms of teratogenesis / Peter G. Wells [and others] -- Mediators/biochemical pathways. Role of reactive metabolites in drug-induced hepatotoxicity / A.M. Srivastava [and others] -- Role of cytokines in the mechanism of adverse drug reactions / Mary Jane Masson, Lindsay A. Collins, Lance R. Poh -- Keap1-Nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity / Ian M. Copple [and others] -- Signal transduction pathways involved in drug-induced liver injury / Derick Han [and others] -- Mictrochondrial involvement in drug-induced liver injury / Dominique Pessayre [and others] -- Examples/Models. Mechanisms of acetaminophen-induced liver necrosis / Jack A. Hinson, Dean W. Roberts, Laura P. James -- Drug-induced liver injury in humans: the case of Ximelagtran / M. Keisu, T.B. Andersson -- Troglitazone / Tsuyoshi Yokoi -- Neviropine hypersensitivity / M. Popovic [and others] -- Mechanisms of adverse drug reactions to biologics / Janet B. Clarke -- Risk factors/screening drug candidates. Pharmacogenetics of idiosyncratic adverse drug reactions / Munir Pirmohamed -- Danger hypothesis applied to idiosyncratic drug reactions / Jinze Li, Jack P. Uetrecht -- Approaches for minimizing metabolic activation of new drug candidates in drug discovery / Sanjeev Kumar [and others]
Control code
SPR608155787
Dimensions
unknown
Extent
1 online resource (x, 556 pages)
Form of item
online
Isbn
9783642006630
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations.
Sound
unknown sound
Specific material designation
remote
Label
Adverse drug reactions, Jack Uetrecht, editor, (electronic book)
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Target organ toxicity. Drug-induced liver injury / Michael Holt, Cynthia Ju -- Drug herpersensitivity reactions involving skin / Oliver Hausmann, Benno Schnyder, Werner J. Pichler -- Adverse drug reactions affecting blood cells / Richard H. Aster -- Molecular mechanisms of adverse drug reactions in cardiac tissue / Reza Tabrizchi -- Mechanisms of drug-induced nephrotoxicity / Thomas D. Nolin, Jonathan Himmelfarb -- Receptor- and reactive intermediate-mediated mechanisms of teratogenesis / Peter G. Wells [and others] -- Mediators/biochemical pathways. Role of reactive metabolites in drug-induced hepatotoxicity / A.M. Srivastava [and others] -- Role of cytokines in the mechanism of adverse drug reactions / Mary Jane Masson, Lindsay A. Collins, Lance R. Poh -- Keap1-Nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity / Ian M. Copple [and others] -- Signal transduction pathways involved in drug-induced liver injury / Derick Han [and others] -- Mictrochondrial involvement in drug-induced liver injury / Dominique Pessayre [and others] -- Examples/Models. Mechanisms of acetaminophen-induced liver necrosis / Jack A. Hinson, Dean W. Roberts, Laura P. James -- Drug-induced liver injury in humans: the case of Ximelagtran / M. Keisu, T.B. Andersson -- Troglitazone / Tsuyoshi Yokoi -- Neviropine hypersensitivity / M. Popovic [and others] -- Mechanisms of adverse drug reactions to biologics / Janet B. Clarke -- Risk factors/screening drug candidates. Pharmacogenetics of idiosyncratic adverse drug reactions / Munir Pirmohamed -- Danger hypothesis applied to idiosyncratic drug reactions / Jinze Li, Jack P. Uetrecht -- Approaches for minimizing metabolic activation of new drug candidates in drug discovery / Sanjeev Kumar [and others]
Control code
SPR608155787
Dimensions
unknown
Extent
1 online resource (x, 556 pages)
Form of item
online
Isbn
9783642006630
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations.
Sound
unknown sound
Specific material designation
remote

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