The Resource Adverse drug reactions, Jack Uetrecht, editor, (electronic book)
Adverse drug reactions, Jack Uetrecht, editor, (electronic book)
Resource Information
The item Adverse drug reactions, Jack Uetrecht, editor, (electronic book) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Liverpool.This item is available to borrow from 1 library branch.
Resource Information
The item Adverse drug reactions, Jack Uetrecht, editor, (electronic book) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Liverpool.
This item is available to borrow from 1 library branch.
- Summary
- This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of what are presently believed to be mediators and biochemical pathways involved in idiosyncratic drug reactions. There is also a description of several examples of ADRs that serve to illustrate specific aspects of ADR mechanisms. Eventually the book shows that ultimately better methods are needed to predict which drug candidates are likely to cause ADRs and which patients are at increased risk. But at present research seems to be far from this goal
- Language
- eng
- Extent
- 1 online resource (x, 556 pages)
- Contents
-
- Target organ toxicity. Drug-induced liver injury / Michael Holt, Cynthia Ju
- Drug herpersensitivity reactions involving skin / Oliver Hausmann, Benno Schnyder, Werner J. Pichler
- Adverse drug reactions affecting blood cells / Richard H. Aster
- Molecular mechanisms of adverse drug reactions in cardiac tissue / Reza Tabrizchi
- Mechanisms of drug-induced nephrotoxicity / Thomas D. Nolin, Jonathan Himmelfarb
- Receptor- and reactive intermediate-mediated mechanisms of teratogenesis / Peter G. Wells [and others]
- Mediators/biochemical pathways. Role of reactive metabolites in drug-induced hepatotoxicity / A.M. Srivastava [and others]
- Role of cytokines in the mechanism of adverse drug reactions / Mary Jane Masson, Lindsay A. Collins, Lance R. Poh
- Keap1-Nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity / Ian M. Copple [and others]
- Signal transduction pathways involved in drug-induced liver injury / Derick Han [and others]
- Mictrochondrial involvement in drug-induced liver injury / Dominique Pessayre [and others]
- Examples/Models. Mechanisms of acetaminophen-induced liver necrosis / Jack A. Hinson, Dean W. Roberts, Laura P. James
- Drug-induced liver injury in humans: the case of Ximelagtran / M. Keisu, T.B. Andersson
- Troglitazone / Tsuyoshi Yokoi
- Neviropine hypersensitivity / M. Popovic [and others]
- Mechanisms of adverse drug reactions to biologics / Janet B. Clarke
- Risk factors/screening drug candidates. Pharmacogenetics of idiosyncratic adverse drug reactions / Munir Pirmohamed
- Danger hypothesis applied to idiosyncratic drug reactions / Jinze Li, Jack P. Uetrecht
- Approaches for minimizing metabolic activation of new drug candidates in drug discovery / Sanjeev Kumar [and others]
- Isbn
- 9783642006630
- Label
- Adverse drug reactions
- Title
- Adverse drug reactions
- Statement of responsibility
- Jack Uetrecht, editor
- Language
- eng
- Summary
- This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of what are presently believed to be mediators and biochemical pathways involved in idiosyncratic drug reactions. There is also a description of several examples of ADRs that serve to illustrate specific aspects of ADR mechanisms. Eventually the book shows that ultimately better methods are needed to predict which drug candidates are likely to cause ADRs and which patients are at increased risk. But at present research seems to be far from this goal
- Cataloging source
- HNK
- Dewey number
- 615.704
- Illustrations
- illustrations
- Index
- index present
- LC call number
- RM302.5
- LC item number
- .U48 2010eb
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- http://library.link/vocab/relatedWorkOrContributorName
- Uetrecht, Jack P.
- http://library.link/vocab/subjectName
-
- Drugs
- Drug Toxicity
- Label
- Adverse drug reactions, Jack Uetrecht, editor, (electronic book)
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Target organ toxicity. Drug-induced liver injury / Michael Holt, Cynthia Ju -- Drug herpersensitivity reactions involving skin / Oliver Hausmann, Benno Schnyder, Werner J. Pichler -- Adverse drug reactions affecting blood cells / Richard H. Aster -- Molecular mechanisms of adverse drug reactions in cardiac tissue / Reza Tabrizchi -- Mechanisms of drug-induced nephrotoxicity / Thomas D. Nolin, Jonathan Himmelfarb -- Receptor- and reactive intermediate-mediated mechanisms of teratogenesis / Peter G. Wells [and others] -- Mediators/biochemical pathways. Role of reactive metabolites in drug-induced hepatotoxicity / A.M. Srivastava [and others] -- Role of cytokines in the mechanism of adverse drug reactions / Mary Jane Masson, Lindsay A. Collins, Lance R. Poh -- Keap1-Nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity / Ian M. Copple [and others] -- Signal transduction pathways involved in drug-induced liver injury / Derick Han [and others] -- Mictrochondrial involvement in drug-induced liver injury / Dominique Pessayre [and others] -- Examples/Models. Mechanisms of acetaminophen-induced liver necrosis / Jack A. Hinson, Dean W. Roberts, Laura P. James -- Drug-induced liver injury in humans: the case of Ximelagtran / M. Keisu, T.B. Andersson -- Troglitazone / Tsuyoshi Yokoi -- Neviropine hypersensitivity / M. Popovic [and others] -- Mechanisms of adverse drug reactions to biologics / Janet B. Clarke -- Risk factors/screening drug candidates. Pharmacogenetics of idiosyncratic adverse drug reactions / Munir Pirmohamed -- Danger hypothesis applied to idiosyncratic drug reactions / Jinze Li, Jack P. Uetrecht -- Approaches for minimizing metabolic activation of new drug candidates in drug discovery / Sanjeev Kumar [and others]
- Control code
- SPR608155787
- Dimensions
- unknown
- Extent
- 1 online resource (x, 556 pages)
- Form of item
- online
- Isbn
- 9783642006630
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- illustrations.
- Sound
- unknown sound
- Specific material designation
- remote
- Label
- Adverse drug reactions, Jack Uetrecht, editor, (electronic book)
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- Target organ toxicity. Drug-induced liver injury / Michael Holt, Cynthia Ju -- Drug herpersensitivity reactions involving skin / Oliver Hausmann, Benno Schnyder, Werner J. Pichler -- Adverse drug reactions affecting blood cells / Richard H. Aster -- Molecular mechanisms of adverse drug reactions in cardiac tissue / Reza Tabrizchi -- Mechanisms of drug-induced nephrotoxicity / Thomas D. Nolin, Jonathan Himmelfarb -- Receptor- and reactive intermediate-mediated mechanisms of teratogenesis / Peter G. Wells [and others] -- Mediators/biochemical pathways. Role of reactive metabolites in drug-induced hepatotoxicity / A.M. Srivastava [and others] -- Role of cytokines in the mechanism of adverse drug reactions / Mary Jane Masson, Lindsay A. Collins, Lance R. Poh -- Keap1-Nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity / Ian M. Copple [and others] -- Signal transduction pathways involved in drug-induced liver injury / Derick Han [and others] -- Mictrochondrial involvement in drug-induced liver injury / Dominique Pessayre [and others] -- Examples/Models. Mechanisms of acetaminophen-induced liver necrosis / Jack A. Hinson, Dean W. Roberts, Laura P. James -- Drug-induced liver injury in humans: the case of Ximelagtran / M. Keisu, T.B. Andersson -- Troglitazone / Tsuyoshi Yokoi -- Neviropine hypersensitivity / M. Popovic [and others] -- Mechanisms of adverse drug reactions to biologics / Janet B. Clarke -- Risk factors/screening drug candidates. Pharmacogenetics of idiosyncratic adverse drug reactions / Munir Pirmohamed -- Danger hypothesis applied to idiosyncratic drug reactions / Jinze Li, Jack P. Uetrecht -- Approaches for minimizing metabolic activation of new drug candidates in drug discovery / Sanjeev Kumar [and others]
- Control code
- SPR608155787
- Dimensions
- unknown
- Extent
- 1 online resource (x, 556 pages)
- Form of item
- online
- Isbn
- 9783642006630
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Other physical details
- illustrations.
- Sound
- unknown sound
- Specific material designation
- remote
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.liverpool.ac.uk/portal/Adverse-drug-reactions-Jack-Uetrecht-editor/o-dIVe18GNY/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.liverpool.ac.uk/portal/Adverse-drug-reactions-Jack-Uetrecht-editor/o-dIVe18GNY/">Adverse drug reactions, Jack Uetrecht, editor, (electronic book)</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.liverpool.ac.uk/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.liverpool.ac.uk/">University of Liverpool</a></span></span></span></span></div>
