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The Resource Animal models of acute neurological injury, Jun Chen, Zao C. Xu, Xiao Ming Xu, John H. Zhang, editors

Animal models of acute neurological injury, Jun Chen, Zao C. Xu, Xiao Ming Xu, John H. Zhang, editors

Editor
Contributor
Summary
Despite numerous recent studies and exciting discoveries in the field, only limited treatments are available today for the victims of acute brain and spinal cord injuries. Animal Models of Acute Neurological Injuries, Second Edition, provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that often inhibit advances in this specialized research field. In the 10 years since publication of the first edition of this book, some animal models have become obsolete, some have stood the test of time, and newer models have emerged to enhance our knowledge of acute neurological injuries. The second edition continues to offer the research community tested approaches for this area of investigation. As with the first edition, top experts have developed and contributed these animal models. The books focus remains hands-on, practical applications of the models, rather than a theoretical approach. Each chapter contains a proven procedure enhanced by clear figures, illustrations, or videos. This new edition presents its readily reproducible protocols with clarity and consistency to best aid neuroscientists and neurobiologists. As with the first edition, the second edition is comprehensive and cutting-edge. Animal Models of Acute Neurological Injuries, Second Edition, is an ideal guide for research professionals, at all stages of their careers, who wish to pursue this vital course of study with the proficiency and precision required by the field
Language
eng
Work
Publication
Edition
Second edition.
Extent
1 online resource
Note
Includes index
Contents
  • Intro; Preface; Contents; Part I: Animal Care and Surgery; Animal Protocol; Regulatory Oversight; Designing the Animal Protocol; Writing the Animal Protocol; References; Anesthesia and Analgesia for Research Animals; Introduction; Pre-anesthetic Considerations and Monitoring; Injectable Anesthetics; Bartiturates; Ketamine; Propofol; Sedative/Tranquilizers; Local Anesthetics; Gaseous Agents; Isoflurane; Sevoflurane; Other Inhalants; Hypothermia; Analgesia; Opioids; Non-steroidal Anti-inflammatory Drugs (NSAIDs); Other Analgesics
  • Special Considerations-Anesthesia and Analgesia for Animal Models of Neurologic DiseasesCerebral Ischemia and Hemorrhage Models; Physiologic Effects of Anesthesia and the Impact on Cerebral Ischemia and Hemorrhage Models; Anesthetic Considerations; Analgesic Considerations; Traumatic Brain Injury Models; Anesthetic Considerations; Analgesic Considerations; Spinal Cord Injury Models; Physiologic Effects of Anesthesia and the Impact on SCI Models; Anesthetic and Analgesic Agents Impact Spinal Injury Models; References; Rodent Surgical Procedures and Tissue Collection; Introduction
  • Airway Management in the Rodent ModelIntubation; Materials; Procedures; Transcardiac Perfusion and Fixation; Equipment and Materials; Step by Step Procedures; Methods of Brain Removal; Materials; Procedures; Brain Removal; Separation of the Brain into Anatomical Sections; Materials; Procedure; Preparation of Brain Slices for Triphenyltetrazolium Chloride Staining; Materials; Procedure; References; Brain Monitoring; Introduction; Model Selection; Materials; Intravenous Femoral Catheter; Procedure; Burr Hole and Brain Monitoring; Postoperative Care; Conclusion; References
  • Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies: An UpdateModel Selection; Materials and Methods; Before Surgery and SCI; Surgery and SCI; Sterilization; Preparation; Surgery and SCI; Acutely and the First Week After Surgery and SCI; Housing; Veterinary Care; Chronically After Surgery and SCI; References; Part II: Cerebral Ischemic Animal Models; Four-Vessel Occlusion Model in Rats; Model Selection; Materials; Animal; Anesthesia; Equipment; Anesthesia; Surgery; Recording of Ischemic Depolarization; Procedures; Original 4-VO Model
  • Placement of Occluding Device Around Carotid ArteryElectrocauterization of Vertebral Artery; Occlusion of Bilateral Common Carotid Arteries; One-Day 4-VO Model (with ID Recording); Surgical Preparation; ID Recording; Outcome Evaluation; Ischemic Cell Death in the Hippocampus; Ischemic Cell Death in the Striatum; Advantages, Complications and Limitations; Advantages; Complications; Limitations; Technical Difficulties; Mortality; Variation; References; Rat Model of Global Cerebral Ischemia: The Two-Vessel Occlusion (2VO) Model of Forebrain Ischemia; Introduction
Isbn
9783030160821
Instance
Label
Animal models of acute neurological injury
Title
Animal models of acute neurological injury
Statement of responsibility
Jun Chen, Zao C. Xu, Xiao Ming Xu, John H. Zhang, editors
Contributor
Editor
Subject
Genre
Language
eng
Summary
Despite numerous recent studies and exciting discoveries in the field, only limited treatments are available today for the victims of acute brain and spinal cord injuries. Animal Models of Acute Neurological Injuries, Second Edition, provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that often inhibit advances in this specialized research field. In the 10 years since publication of the first edition of this book, some animal models have become obsolete, some have stood the test of time, and newer models have emerged to enhance our knowledge of acute neurological injuries. The second edition continues to offer the research community tested approaches for this area of investigation. As with the first edition, top experts have developed and contributed these animal models. The books focus remains hands-on, practical applications of the models, rather than a theoretical approach. Each chapter contains a proven procedure enhanced by clear figures, illustrations, or videos. This new edition presents its readily reproducible protocols with clarity and consistency to best aid neuroscientists and neurobiologists. As with the first edition, the second edition is comprehensive and cutting-edge. Animal Models of Acute Neurological Injuries, Second Edition, is an ideal guide for research professionals, at all stages of their careers, who wish to pursue this vital course of study with the proficiency and precision required by the field
Member of
Cataloging source
EBLCP
Dewey number
612.8
Index
index present
LC call number
RC337
LC item number
.A55 2019
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Chen, Jun
  • Xu, Zao C.
  • Xu, Xiao-Ming
  • Zhang, J. H.
Series statement
Springer series in translational stroke research
http://library.link/vocab/subjectName
  • Nervous system
  • Nervous system
  • Nervous system
Label
Animal models of acute neurological injury, Jun Chen, Zao C. Xu, Xiao Ming Xu, John H. Zhang, editors
Instantiates
Publication
Note
Includes index
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Intro; Preface; Contents; Part I: Animal Care and Surgery; Animal Protocol; Regulatory Oversight; Designing the Animal Protocol; Writing the Animal Protocol; References; Anesthesia and Analgesia for Research Animals; Introduction; Pre-anesthetic Considerations and Monitoring; Injectable Anesthetics; Bartiturates; Ketamine; Propofol; Sedative/Tranquilizers; Local Anesthetics; Gaseous Agents; Isoflurane; Sevoflurane; Other Inhalants; Hypothermia; Analgesia; Opioids; Non-steroidal Anti-inflammatory Drugs (NSAIDs); Other Analgesics
  • Special Considerations-Anesthesia and Analgesia for Animal Models of Neurologic DiseasesCerebral Ischemia and Hemorrhage Models; Physiologic Effects of Anesthesia and the Impact on Cerebral Ischemia and Hemorrhage Models; Anesthetic Considerations; Analgesic Considerations; Traumatic Brain Injury Models; Anesthetic Considerations; Analgesic Considerations; Spinal Cord Injury Models; Physiologic Effects of Anesthesia and the Impact on SCI Models; Anesthetic and Analgesic Agents Impact Spinal Injury Models; References; Rodent Surgical Procedures and Tissue Collection; Introduction
  • Airway Management in the Rodent ModelIntubation; Materials; Procedures; Transcardiac Perfusion and Fixation; Equipment and Materials; Step by Step Procedures; Methods of Brain Removal; Materials; Procedures; Brain Removal; Separation of the Brain into Anatomical Sections; Materials; Procedure; Preparation of Brain Slices for Triphenyltetrazolium Chloride Staining; Materials; Procedure; References; Brain Monitoring; Introduction; Model Selection; Materials; Intravenous Femoral Catheter; Procedure; Burr Hole and Brain Monitoring; Postoperative Care; Conclusion; References
  • Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies: An UpdateModel Selection; Materials and Methods; Before Surgery and SCI; Surgery and SCI; Sterilization; Preparation; Surgery and SCI; Acutely and the First Week After Surgery and SCI; Housing; Veterinary Care; Chronically After Surgery and SCI; References; Part II: Cerebral Ischemic Animal Models; Four-Vessel Occlusion Model in Rats; Model Selection; Materials; Animal; Anesthesia; Equipment; Anesthesia; Surgery; Recording of Ischemic Depolarization; Procedures; Original 4-VO Model
  • Placement of Occluding Device Around Carotid ArteryElectrocauterization of Vertebral Artery; Occlusion of Bilateral Common Carotid Arteries; One-Day 4-VO Model (with ID Recording); Surgical Preparation; ID Recording; Outcome Evaluation; Ischemic Cell Death in the Hippocampus; Ischemic Cell Death in the Striatum; Advantages, Complications and Limitations; Advantages; Complications; Limitations; Technical Difficulties; Mortality; Variation; References; Rat Model of Global Cerebral Ischemia: The Two-Vessel Occlusion (2VO) Model of Forebrain Ischemia; Introduction
Control code
on1110486583
Dimensions
unknown
Edition
Second edition.
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9783030160821
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
  • 10.1007/978-3-030-16
  • 10.1007/978-3-030-16082-1
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)1110486583
Label
Animal models of acute neurological injury, Jun Chen, Zao C. Xu, Xiao Ming Xu, John H. Zhang, editors
Publication
Note
Includes index
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Intro; Preface; Contents; Part I: Animal Care and Surgery; Animal Protocol; Regulatory Oversight; Designing the Animal Protocol; Writing the Animal Protocol; References; Anesthesia and Analgesia for Research Animals; Introduction; Pre-anesthetic Considerations and Monitoring; Injectable Anesthetics; Bartiturates; Ketamine; Propofol; Sedative/Tranquilizers; Local Anesthetics; Gaseous Agents; Isoflurane; Sevoflurane; Other Inhalants; Hypothermia; Analgesia; Opioids; Non-steroidal Anti-inflammatory Drugs (NSAIDs); Other Analgesics
  • Special Considerations-Anesthesia and Analgesia for Animal Models of Neurologic DiseasesCerebral Ischemia and Hemorrhage Models; Physiologic Effects of Anesthesia and the Impact on Cerebral Ischemia and Hemorrhage Models; Anesthetic Considerations; Analgesic Considerations; Traumatic Brain Injury Models; Anesthetic Considerations; Analgesic Considerations; Spinal Cord Injury Models; Physiologic Effects of Anesthesia and the Impact on SCI Models; Anesthetic and Analgesic Agents Impact Spinal Injury Models; References; Rodent Surgical Procedures and Tissue Collection; Introduction
  • Airway Management in the Rodent ModelIntubation; Materials; Procedures; Transcardiac Perfusion and Fixation; Equipment and Materials; Step by Step Procedures; Methods of Brain Removal; Materials; Procedures; Brain Removal; Separation of the Brain into Anatomical Sections; Materials; Procedure; Preparation of Brain Slices for Triphenyltetrazolium Chloride Staining; Materials; Procedure; References; Brain Monitoring; Introduction; Model Selection; Materials; Intravenous Femoral Catheter; Procedure; Burr Hole and Brain Monitoring; Postoperative Care; Conclusion; References
  • Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies: An UpdateModel Selection; Materials and Methods; Before Surgery and SCI; Surgery and SCI; Sterilization; Preparation; Surgery and SCI; Acutely and the First Week After Surgery and SCI; Housing; Veterinary Care; Chronically After Surgery and SCI; References; Part II: Cerebral Ischemic Animal Models; Four-Vessel Occlusion Model in Rats; Model Selection; Materials; Animal; Anesthesia; Equipment; Anesthesia; Surgery; Recording of Ischemic Depolarization; Procedures; Original 4-VO Model
  • Placement of Occluding Device Around Carotid ArteryElectrocauterization of Vertebral Artery; Occlusion of Bilateral Common Carotid Arteries; One-Day 4-VO Model (with ID Recording); Surgical Preparation; ID Recording; Outcome Evaluation; Ischemic Cell Death in the Hippocampus; Ischemic Cell Death in the Striatum; Advantages, Complications and Limitations; Advantages; Complications; Limitations; Technical Difficulties; Mortality; Variation; References; Rat Model of Global Cerebral Ischemia: The Two-Vessel Occlusion (2VO) Model of Forebrain Ischemia; Introduction
Control code
on1110486583
Dimensions
unknown
Edition
Second edition.
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9783030160821
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
  • 10.1007/978-3-030-16
  • 10.1007/978-3-030-16082-1
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)1110486583

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