Coverart for item
The Resource Aromatase inhibitors, edited by B.J.A. Furr, (electronic book)

Aromatase inhibitors, edited by B.J.A. Furr, (electronic book)

Label
Aromatase inhibitors
Title
Aromatase inhibitors
Statement of responsibility
edited by B.J.A. Furr
Contributor
Subject
Language
eng
Summary
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy
Member of
Cataloging source
COO
Dewey number
616.99/449061
Illustrations
illustrations
Index
index present
LC call number
RC280.B8
LC item number
A76 2006
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Furr, B. J. A
Series statement
Milestones in drug therapy
http://library.link/vocab/subjectName
  • Breast
  • Aromatase
  • Breast Neoplasms
  • Aromatase Inhibitors
Label
Aromatase inhibitors, edited by B.J.A. Furr, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Background and development of aromatase inhibitors -- Aromatase inhibitors and models for breast cancer -- Clinical pharmacology of aromatase inhibitors -- Clinical studies with exemestane -- Clinical studies with letrozole -- Clinical studies with anastrozole -- The third-generation aromatase inhibitors: a clinical overview -- Lessons from the ArKO mouse -- Possible additional therapeutic uses of aromatase inhibitors
Control code
SPR68001205
Dimensions
unknown
Extent
1 online resource (ix, 182 pages)
Form of item
online
Isbn
9783764371999
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Specific material designation
remote
Label
Aromatase inhibitors, edited by B.J.A. Furr, (electronic book)
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Background and development of aromatase inhibitors -- Aromatase inhibitors and models for breast cancer -- Clinical pharmacology of aromatase inhibitors -- Clinical studies with exemestane -- Clinical studies with letrozole -- Clinical studies with anastrozole -- The third-generation aromatase inhibitors: a clinical overview -- Lessons from the ArKO mouse -- Possible additional therapeutic uses of aromatase inhibitors
Control code
SPR68001205
Dimensions
unknown
Extent
1 online resource (ix, 182 pages)
Form of item
online
Isbn
9783764371999
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Specific material designation
remote

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