Coverart for item
The Resource Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis, Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen, (electronic book)

Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis, Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen, (electronic book)

Label
Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis
Title
Astroglia and brain metabolism
Title remainder
focus on energy and neurotransmitter amino acid homeostasis
Statement of responsibility
Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen
Creator
Contributor
Author
Subject
Language
eng
Summary
The present outline of astrocytic metabolic pathways involved in glucose and amino acid metabolism provides detailed information about the enzymatic pathways involved, as well as a description of the basic properties of the enzymes including regulatory mechanisms. Hence, the glycolytic pathway and glycogen metabolism are outlined, followed by a detailed account of pyruvate oxidation and its role as a substrate for the tricarboxylic acid (TCA) cycle. Moreover, a detailed description of the main enzymes involved in glutamate metabolism is provided and the role of the glutamate-glutamine cycle is explained. Since this text is primarily covering astrocytic metabolism, an emphasis has been placed on a discussion of the significance of the astrocyte specific enzymes pyruvate carboxylase and glutamine synthetase, which enable these cells to perform a net synthesis of glutamine, the precursor for synthesis of glutamate and ã-aminobutyrate (GABA), the main neurotransmitters of the brain. With this, we have underlined the fundamental importance of astrocytic metabolism for neuronal function with a particular emphasis on the fact that, without continuous support from the astrocytic partners in synaptic function, glutamatergic and GABAergic neurotransmission would not be possible. It is thought provoking that these neurotransmission processes, which account for the vast majority of synaptic activity in the brain, have been made totally dependent on astrocytic metabolic support, particularly with regard to replenishment of the respective neurotransmitters
Member of
Cataloging source
CaBNVSL
http://library.link/vocab/creatorName
Schousboe, Arne
Dewey number
611.0188
Illustrations
illustrations
Index
no index present
LC call number
QP363.2
LC item number
.S352 2015
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Walls, Anne B.
  • Bak, Lasse K.
  • Waagepetersen, Helle S.
Series statement
Colloquium series on neuroglia in biology and medicine,
Series volume
7
http://library.link/vocab/subjectName
  • Astrocytes
  • Brain
  • Amino acids
  • Astrocytes
  • Brain
  • Amino Acids
Target audience
  • adult
  • specialized
Label
Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis, Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (pages 37-63)
Carrier category
online resource
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type MARC source
rdacontent
Contents
  • 1. Introduction to glia --
  • 2. Metabolism of glia -- 2.1 Glucose and glycogen metabolism -- 2.1.1 Glycolysis -- 2.1.2 Glycogen synthesis and glycogenolysis -- 2.2 Pentose phosphate shunt -- 2.3 The functional importance of the glycogen-shunt -- 2.4 Lactate production and shuttling -- 2.4.1 Functional importance of LDH isozymes for lactate shuttling -- 2.5 Pyruvate oxidation and the tricarboxylic acid (TCA) cycle -- 2.5.1 Compartmentation of astrocytic pyruvate and TCA cycle metabolism -- 2.5.2 Regulatory roles of calcium in the TCA cycle -- 2.6 Pyruvate recycling and lactate production from TCA cycle intermediates -- 2.7 Pyruvate carboxylation -- 2.7.1 Pyruvate carboxylation and glutamine biosynthesis -- 2.7.2 Pyruvate carboxylation and synthesis of TCA cycle intermediates -- 2.8 Glutamate and glutamine metabolism and homeostasis: the glutamate-glutamine cycle -- 2.8.1 Enzymes -- 2.8.2 Glutamate transporters -- 2.8.3 Glutamine transporters -- 2.8.4 Glutamate as an energy substrate -- 2.8.5 Glutamate as a neurotoxin -- 2.8.6 Ammonia homeostasis and hepatic encephalopathy -- 2.9 GABA metabolism and homeostasis -- 2.9.1 Enzymes -- 2.9.2 GABA transporters and seizure control --
  • 3. Concluding remarks -- References -- Author biographies
Control code
201506NGL007
Dimensions
unknown
Extent
1 PDF (viii, 66 pages)
File format
multiple file formats
Form of item
online
Isbn
9781615047130
Media category
electronic
Media MARC source
isbdmedia
Other control number
10.4199/C00130ED1V01Y201506NGL007
Other physical details
illustrations.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis, Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen, (electronic book)
Publication
Bibliography note
Includes bibliographical references (pages 37-63)
Carrier category
online resource
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type MARC source
rdacontent
Contents
  • 1. Introduction to glia --
  • 2. Metabolism of glia -- 2.1 Glucose and glycogen metabolism -- 2.1.1 Glycolysis -- 2.1.2 Glycogen synthesis and glycogenolysis -- 2.2 Pentose phosphate shunt -- 2.3 The functional importance of the glycogen-shunt -- 2.4 Lactate production and shuttling -- 2.4.1 Functional importance of LDH isozymes for lactate shuttling -- 2.5 Pyruvate oxidation and the tricarboxylic acid (TCA) cycle -- 2.5.1 Compartmentation of astrocytic pyruvate and TCA cycle metabolism -- 2.5.2 Regulatory roles of calcium in the TCA cycle -- 2.6 Pyruvate recycling and lactate production from TCA cycle intermediates -- 2.7 Pyruvate carboxylation -- 2.7.1 Pyruvate carboxylation and glutamine biosynthesis -- 2.7.2 Pyruvate carboxylation and synthesis of TCA cycle intermediates -- 2.8 Glutamate and glutamine metabolism and homeostasis: the glutamate-glutamine cycle -- 2.8.1 Enzymes -- 2.8.2 Glutamate transporters -- 2.8.3 Glutamine transporters -- 2.8.4 Glutamate as an energy substrate -- 2.8.5 Glutamate as a neurotoxin -- 2.8.6 Ammonia homeostasis and hepatic encephalopathy -- 2.9 GABA metabolism and homeostasis -- 2.9.1 Enzymes -- 2.9.2 GABA transporters and seizure control --
  • 3. Concluding remarks -- References -- Author biographies
Control code
201506NGL007
Dimensions
unknown
Extent
1 PDF (viii, 66 pages)
File format
multiple file formats
Form of item
online
Isbn
9781615047130
Media category
electronic
Media MARC source
isbdmedia
Other control number
10.4199/C00130ED1V01Y201506NGL007
Other physical details
illustrations.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

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