The Resource Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis, Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen, (electronic book)
Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis, Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen, (electronic book)
Resource Information
The item Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis, Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen, (electronic book) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Sydney Jones Library, University of Liverpool.This item is available to borrow from 1 library branch.
Resource Information
The item Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis, Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen, (electronic book) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Sydney Jones Library, University of Liverpool.
This item is available to borrow from 1 library branch.
- Summary
- The present outline of astrocytic metabolic pathways involved in glucose and amino acid metabolism provides detailed information about the enzymatic pathways involved, as well as a description of the basic properties of the enzymes including regulatory mechanisms. Hence, the glycolytic pathway and glycogen metabolism are outlined, followed by a detailed account of pyruvate oxidation and its role as a substrate for the tricarboxylic acid (TCA) cycle. Moreover, a detailed description of the main enzymes involved in glutamate metabolism is provided and the role of the glutamate-glutamine cycle is explained. Since this text is primarily covering astrocytic metabolism, an emphasis has been placed on a discussion of the significance of the astrocyte specific enzymes pyruvate carboxylase and glutamine synthetase, which enable these cells to perform a net synthesis of glutamine, the precursor for synthesis of glutamate and ã-aminobutyrate (GABA), the main neurotransmitters of the brain. With this, we have underlined the fundamental importance of astrocytic metabolism for neuronal function with a particular emphasis on the fact that, without continuous support from the astrocytic partners in synaptic function, glutamatergic and GABAergic neurotransmission would not be possible. It is thought provoking that these neurotransmission processes, which account for the vast majority of synaptic activity in the brain, have been made totally dependent on astrocytic metabolic support, particularly with regard to replenishment of the respective neurotransmitters
- Language
- eng
- Extent
- 1 PDF (viii, 66 pages)
- Contents
-
- 1. Introduction to glia --
- 2. Metabolism of glia -- 2.1 Glucose and glycogen metabolism -- 2.1.1 Glycolysis -- 2.1.2 Glycogen synthesis and glycogenolysis -- 2.2 Pentose phosphate shunt -- 2.3 The functional importance of the glycogen-shunt -- 2.4 Lactate production and shuttling -- 2.4.1 Functional importance of LDH isozymes for lactate shuttling -- 2.5 Pyruvate oxidation and the tricarboxylic acid (TCA) cycle -- 2.5.1 Compartmentation of astrocytic pyruvate and TCA cycle metabolism -- 2.5.2 Regulatory roles of calcium in the TCA cycle -- 2.6 Pyruvate recycling and lactate production from TCA cycle intermediates -- 2.7 Pyruvate carboxylation -- 2.7.1 Pyruvate carboxylation and glutamine biosynthesis -- 2.7.2 Pyruvate carboxylation and synthesis of TCA cycle intermediates -- 2.8 Glutamate and glutamine metabolism and homeostasis: the glutamate-glutamine cycle -- 2.8.1 Enzymes -- 2.8.2 Glutamate transporters -- 2.8.3 Glutamine transporters -- 2.8.4 Glutamate as an energy substrate -- 2.8.5 Glutamate as a neurotoxin -- 2.8.6 Ammonia homeostasis and hepatic encephalopathy -- 2.9 GABA metabolism and homeostasis -- 2.9.1 Enzymes -- 2.9.2 GABA transporters and seizure control --
- 3. Concluding remarks -- References -- Author biographies
- Isbn
- 9781615047130
- Label
- Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis
- Title
- Astroglia and brain metabolism
- Title remainder
- focus on energy and neurotransmitter amino acid homeostasis
- Statement of responsibility
- Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen
- Language
- eng
- Summary
- The present outline of astrocytic metabolic pathways involved in glucose and amino acid metabolism provides detailed information about the enzymatic pathways involved, as well as a description of the basic properties of the enzymes including regulatory mechanisms. Hence, the glycolytic pathway and glycogen metabolism are outlined, followed by a detailed account of pyruvate oxidation and its role as a substrate for the tricarboxylic acid (TCA) cycle. Moreover, a detailed description of the main enzymes involved in glutamate metabolism is provided and the role of the glutamate-glutamine cycle is explained. Since this text is primarily covering astrocytic metabolism, an emphasis has been placed on a discussion of the significance of the astrocyte specific enzymes pyruvate carboxylase and glutamine synthetase, which enable these cells to perform a net synthesis of glutamine, the precursor for synthesis of glutamate and ã-aminobutyrate (GABA), the main neurotransmitters of the brain. With this, we have underlined the fundamental importance of astrocytic metabolism for neuronal function with a particular emphasis on the fact that, without continuous support from the astrocytic partners in synaptic function, glutamatergic and GABAergic neurotransmission would not be possible. It is thought provoking that these neurotransmission processes, which account for the vast majority of synaptic activity in the brain, have been made totally dependent on astrocytic metabolic support, particularly with regard to replenishment of the respective neurotransmitters
- Cataloging source
- CaBNVSL
- http://library.link/vocab/creatorName
- Schousboe, Arne
- Dewey number
- 611.0188
- Illustrations
- illustrations
- Index
- no index present
- LC call number
- QP363.2
- LC item number
- .S352 2015
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- abstracts summaries
- bibliography
- http://library.link/vocab/relatedWorkOrContributorName
-
- Walls, Anne B.
- Bak, Lasse K.
- Waagepetersen, Helle S.
- Series statement
- Colloquium series on neuroglia in biology and medicine,
- Series volume
- 7
- http://library.link/vocab/subjectName
-
- Astrocytes
- Brain
- Amino acids
- Astrocytes
- Brain
- Amino Acids
- Target audience
-
- adult
- specialized
- Label
- Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis, Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen, (electronic book)
- Bibliography note
- Includes bibliographical references (pages 37-63)
- Carrier category
- online resource
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type MARC source
- rdacontent
- Contents
-
- 1. Introduction to glia --
- 2. Metabolism of glia -- 2.1 Glucose and glycogen metabolism -- 2.1.1 Glycolysis -- 2.1.2 Glycogen synthesis and glycogenolysis -- 2.2 Pentose phosphate shunt -- 2.3 The functional importance of the glycogen-shunt -- 2.4 Lactate production and shuttling -- 2.4.1 Functional importance of LDH isozymes for lactate shuttling -- 2.5 Pyruvate oxidation and the tricarboxylic acid (TCA) cycle -- 2.5.1 Compartmentation of astrocytic pyruvate and TCA cycle metabolism -- 2.5.2 Regulatory roles of calcium in the TCA cycle -- 2.6 Pyruvate recycling and lactate production from TCA cycle intermediates -- 2.7 Pyruvate carboxylation -- 2.7.1 Pyruvate carboxylation and glutamine biosynthesis -- 2.7.2 Pyruvate carboxylation and synthesis of TCA cycle intermediates -- 2.8 Glutamate and glutamine metabolism and homeostasis: the glutamate-glutamine cycle -- 2.8.1 Enzymes -- 2.8.2 Glutamate transporters -- 2.8.3 Glutamine transporters -- 2.8.4 Glutamate as an energy substrate -- 2.8.5 Glutamate as a neurotoxin -- 2.8.6 Ammonia homeostasis and hepatic encephalopathy -- 2.9 GABA metabolism and homeostasis -- 2.9.1 Enzymes -- 2.9.2 GABA transporters and seizure control --
- 3. Concluding remarks -- References -- Author biographies
- Control code
- 201506NGL007
- Dimensions
- unknown
- Extent
- 1 PDF (viii, 66 pages)
- File format
- multiple file formats
- Form of item
- online
- Isbn
- 9781615047130
- Media category
- electronic
- Media MARC source
- isbdmedia
- Other control number
- 10.4199/C00130ED1V01Y201506NGL007
- Other physical details
- illustrations.
- Reformatting quality
- access
- Specific material designation
- remote
- System details
- System requirements: Adobe Acrobat reader
- Label
- Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis, Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen, (electronic book)
- Bibliography note
- Includes bibliographical references (pages 37-63)
- Carrier category
- online resource
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type MARC source
- rdacontent
- Contents
-
- 1. Introduction to glia --
- 2. Metabolism of glia -- 2.1 Glucose and glycogen metabolism -- 2.1.1 Glycolysis -- 2.1.2 Glycogen synthesis and glycogenolysis -- 2.2 Pentose phosphate shunt -- 2.3 The functional importance of the glycogen-shunt -- 2.4 Lactate production and shuttling -- 2.4.1 Functional importance of LDH isozymes for lactate shuttling -- 2.5 Pyruvate oxidation and the tricarboxylic acid (TCA) cycle -- 2.5.1 Compartmentation of astrocytic pyruvate and TCA cycle metabolism -- 2.5.2 Regulatory roles of calcium in the TCA cycle -- 2.6 Pyruvate recycling and lactate production from TCA cycle intermediates -- 2.7 Pyruvate carboxylation -- 2.7.1 Pyruvate carboxylation and glutamine biosynthesis -- 2.7.2 Pyruvate carboxylation and synthesis of TCA cycle intermediates -- 2.8 Glutamate and glutamine metabolism and homeostasis: the glutamate-glutamine cycle -- 2.8.1 Enzymes -- 2.8.2 Glutamate transporters -- 2.8.3 Glutamine transporters -- 2.8.4 Glutamate as an energy substrate -- 2.8.5 Glutamate as a neurotoxin -- 2.8.6 Ammonia homeostasis and hepatic encephalopathy -- 2.9 GABA metabolism and homeostasis -- 2.9.1 Enzymes -- 2.9.2 GABA transporters and seizure control --
- 3. Concluding remarks -- References -- Author biographies
- Control code
- 201506NGL007
- Dimensions
- unknown
- Extent
- 1 PDF (viii, 66 pages)
- File format
- multiple file formats
- Form of item
- online
- Isbn
- 9781615047130
- Media category
- electronic
- Media MARC source
- isbdmedia
- Other control number
- 10.4199/C00130ED1V01Y201506NGL007
- Other physical details
- illustrations.
- Reformatting quality
- access
- Specific material designation
- remote
- System details
- System requirements: Adobe Acrobat reader
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.liverpool.ac.uk/portal/Astroglia-and-brain-metabolism--focus-on-energy/K9nAGzLFf6o/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.liverpool.ac.uk/portal/Astroglia-and-brain-metabolism--focus-on-energy/K9nAGzLFf6o/">Astroglia and brain metabolism : focus on energy and neurotransmitter amino acid homeostasis, Arne Schousboe, Anne B. Walls, Lasse K. Bak, and Helle S. Waagepetersen, (electronic book)</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.liverpool.ac.uk/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.liverpool.ac.uk/">Sydney Jones Library, University of Liverpool</a></span></span></span></span></div>
