Coverart for item
The Resource Biometals in neurodegenerative diseases : mechanisms and therapeutics, edited by Anthony R. White, Michael Aschner, Lucio G. Costa, Ashley I. Bush, (electronic book)

Biometals in neurodegenerative diseases : mechanisms and therapeutics, edited by Anthony R. White, Michael Aschner, Lucio G. Costa, Ashley I. Bush, (electronic book)

Label
Biometals in neurodegenerative diseases : mechanisms and therapeutics
Title
Biometals in neurodegenerative diseases
Title remainder
mechanisms and therapeutics
Statement of responsibility
edited by Anthony R. White, Michael Aschner, Lucio G. Costa, Ashley I. Bush
Subject
Language
eng
Cataloging source
YDX
Dewey number
612/.01524
LC call number
QP532
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/subjectName
  • Metals in the body
  • Nervous system
  • Metals
Label
Biometals in neurodegenerative diseases : mechanisms and therapeutics, edited by Anthony R. White, Michael Aschner, Lucio G. Costa, Ashley I. Bush, (electronic book)
Instantiates
Publication
Note
Includes index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Cover; Title page; Copyright page; Contents; Contributors; Preface; Chapter 1 -- Biometals and Alzheimer's Disease; Introduction; The Role of Copper in AD; The Role of Zinc in AD; The Role of Iron in AD; Therapeutic Targeting of Biometals in AD; Conclusions; References; Chapter 2 -- Copper in Alzheimer's Disease; Introduction; The Physiology of Copper; Copper Absorption and Distribution; Copper in the Liver; Copper's Path From General Circulation to the Brain; The Key Role of Ceruloplasmin; Copper Toxicity; The Role of Copper in Alzheimer's Disease; Genetics of Copper and AD
  • The AD Copper SubtypeConclusions; References; Chapter 3 -- The Role of Selenium in Neurodegenerative Diseases; Introduction; Selenoproteins and the Selenoproteome; Selenium and Alzheimer's Disease; Parkinson's Disease; Other Neurodegenerative Diseases; Conclusions; References; Chapter 4 -- Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response?; Iron; Hemochromatosis; Discovery; Types; HFE; Structure; Function; Polymorphisms; Macrophages; Macrophage and Iron Metabolism; Macrophage Polarization; Macrophages and HFE; HFE and Neurodegenerative Diseases
  • Alzheimer's DiseaseAmyotrophic Lateral Sclerosis; Parkinson's Disease; HFE and Cancer; HFE Animal Models; Conclusions; References; Chapter 5 -- Chemical Elements and Oxidative Status in Neuroinflammation; Introduction; Metal-Induced Neurotoxicity and Multiple Sclerosis; Metals and Oxidative Status in Multiple Sclerosis; Metals and Oxidative Status in Clinically Isolated Syndromes; Conclusions; References; Chapter 6 -- Metals and Neuroinflammation; Introduction; Mechanisms by Which Metal Elements Can Incite Immune Activity; Metals as Haptens; Metal Elements with Valence Instability; Copper (Cu)
  • Iron (Fe)Manganese; Metals Attaching to Sulfhydryl Residues; Lead (Pb); Mercury (Hg); Metals Associated with Particulate and Colloidal Materials; Aluminum (Al); Titanium, Silver and Gold (Ti, Ag, Au); Metals Which Lead to Oxidative Stress and Inflammation by Means that are not yet Understood; The Relation Between Reactive Oxygen and Nitrogen Species and Inflammation; Conclusions; References; Chapter 7 -- Metals and Prions: Twenty Years of Mining the Awe; Prion Diseases; Prion Protein; Prion Protein Function; Copper and PrP; Zinc and PrP; Iron and PrP; Manganese and PrP; Metals in Prion Disease
  • Chelation Therapy and Prion DiseaseConclusions; References; Chapter 8 -- Manganese and Neurodegeneration; Background; Mn Essentiality and Metabolic Functions; Mn Biokinetics and Homeostatic Control; Routes and Sources of Mn Exposure; Absorption of Airborne Mn; Parenteral Exposure to Mn; Oral Absorption of Mn From Food and Water; Mn Biodistribution and Elimination; Biokinetics of Mn in Brain; Mn Transport Into Brain; Regional Delivery of Mn in the Brain; Mn Elimination From Brain Compartment; Subcellular Distribution of Mn in Brain; Homeostatic Control of Mn
Dimensions
unknown
Extent
1 online resource.
Form of item
online
Isbn
9780128045633
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
Online access with subscription: Elsevier (Sciencedirect Freedom Collection)
Specific material designation
remote
Label
Biometals in neurodegenerative diseases : mechanisms and therapeutics, edited by Anthony R. White, Michael Aschner, Lucio G. Costa, Ashley I. Bush, (electronic book)
Publication
Note
Includes index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Cover; Title page; Copyright page; Contents; Contributors; Preface; Chapter 1 -- Biometals and Alzheimer's Disease; Introduction; The Role of Copper in AD; The Role of Zinc in AD; The Role of Iron in AD; Therapeutic Targeting of Biometals in AD; Conclusions; References; Chapter 2 -- Copper in Alzheimer's Disease; Introduction; The Physiology of Copper; Copper Absorption and Distribution; Copper in the Liver; Copper's Path From General Circulation to the Brain; The Key Role of Ceruloplasmin; Copper Toxicity; The Role of Copper in Alzheimer's Disease; Genetics of Copper and AD
  • The AD Copper SubtypeConclusions; References; Chapter 3 -- The Role of Selenium in Neurodegenerative Diseases; Introduction; Selenoproteins and the Selenoproteome; Selenium and Alzheimer's Disease; Parkinson's Disease; Other Neurodegenerative Diseases; Conclusions; References; Chapter 4 -- Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response?; Iron; Hemochromatosis; Discovery; Types; HFE; Structure; Function; Polymorphisms; Macrophages; Macrophage and Iron Metabolism; Macrophage Polarization; Macrophages and HFE; HFE and Neurodegenerative Diseases
  • Alzheimer's DiseaseAmyotrophic Lateral Sclerosis; Parkinson's Disease; HFE and Cancer; HFE Animal Models; Conclusions; References; Chapter 5 -- Chemical Elements and Oxidative Status in Neuroinflammation; Introduction; Metal-Induced Neurotoxicity and Multiple Sclerosis; Metals and Oxidative Status in Multiple Sclerosis; Metals and Oxidative Status in Clinically Isolated Syndromes; Conclusions; References; Chapter 6 -- Metals and Neuroinflammation; Introduction; Mechanisms by Which Metal Elements Can Incite Immune Activity; Metals as Haptens; Metal Elements with Valence Instability; Copper (Cu)
  • Iron (Fe)Manganese; Metals Attaching to Sulfhydryl Residues; Lead (Pb); Mercury (Hg); Metals Associated with Particulate and Colloidal Materials; Aluminum (Al); Titanium, Silver and Gold (Ti, Ag, Au); Metals Which Lead to Oxidative Stress and Inflammation by Means that are not yet Understood; The Relation Between Reactive Oxygen and Nitrogen Species and Inflammation; Conclusions; References; Chapter 7 -- Metals and Prions: Twenty Years of Mining the Awe; Prion Diseases; Prion Protein; Prion Protein Function; Copper and PrP; Zinc and PrP; Iron and PrP; Manganese and PrP; Metals in Prion Disease
  • Chelation Therapy and Prion DiseaseConclusions; References; Chapter 8 -- Manganese and Neurodegeneration; Background; Mn Essentiality and Metabolic Functions; Mn Biokinetics and Homeostatic Control; Routes and Sources of Mn Exposure; Absorption of Airborne Mn; Parenteral Exposure to Mn; Oral Absorption of Mn From Food and Water; Mn Biodistribution and Elimination; Biokinetics of Mn in Brain; Mn Transport Into Brain; Regional Delivery of Mn in the Brain; Mn Elimination From Brain Compartment; Subcellular Distribution of Mn in Brain; Homeostatic Control of Mn
Dimensions
unknown
Extent
1 online resource.
Form of item
online
Isbn
9780128045633
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
Online access with subscription: Elsevier (Sciencedirect Freedom Collection)
Specific material designation
remote

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