The Resource Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection, Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis, (electronic book)
Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection, Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis, (electronic book)
Resource Information
The item Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection, Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis, (electronic book) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Liverpool.This item is available to borrow from 1 library branch.
Resource Information
The item Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection, Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis, (electronic book) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in University of Liverpool.
This item is available to borrow from 1 library branch.
- Summary
- The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects of ischemia/reperfusion (I/R). We begin with a discussion of the concept of hormesis (a term used most extensively in the toxicologic literature which refers to biphasic cellular responses that depend on concentration or intensity of a stimulus), review the seminal studies that led to the discovery of the cardioprotective effects of ischemic preconditioning, and outline its therapeutic potential (Chapter 1). This is followed by a summary of our current understanding of the mechanisms of I/R injury (Chapter 2 ), as this provides several points of intervention in limiting postischemic tissue injury that may be targeted by the adaptive programs invoked by conditioning stimuli. Chapters 3 and 4 focus on the mechanisms underlying ischemic pre-, post-, and remote conditioning, which establishes the mechanistic rationale for development of pharmacologic conditioning strategies that may mimic the remarkably powerful effects of ischemic conditioning (and are covered in Chapter 5 ). Lifestyle interventions, including exercise, caloric restriction, and consumption of alcoholic beverages and/or phytochemicals, that may induce hormetic responses will also be reviewed in this chapter. While the promise for conditioning as a therapeutic approach is enormous, there are obstacles to its practical application in patients, which are covered in Chapter 6 . The final chapter (Chapter 7 ) examines the extension of our mechanistic understanding of the signaling pathways invoked by conditioning stimuli into the realm of gene therapy and to the preservation of stem cell viability in the harsh ischemic environment as natural translational outgrowths of preconditioning into therapeutics
- Language
- eng
- Extent
- 1 PDF (viii, pages)
- Note
- Part of: Colloquium digital library of life sciences
- Contents
-
- 1. Hormesis and preconditioning defined --1.1 Hormesis: definition and characteristics -- 1.2 Ischemic conditioning is a specific type of hormetic response -- 1.3 Chemical hormesis and pharmacologic conditioning --
- 2. Mechanisms of ischemia/reperfusion injury -- 2.1 General features of ischemia/reperfusion (I/R) -- 2.2 Ischemic versus reperfusion components of total tissue injury induced by I/R -- 2.2.1 Mechanisms of ischemic injury -- 2.2.2 Pathogenesis of reperfusion injury -- 2.2.3 Oxidative/nitrosative stress -- 2.2.4 Inflammation contributes to reperfusion injury -- 2.3 Risk factors for I/R -- 2.4 Why pursue preconditioning as a therapeutic option in I/R? --
- 3. Ischemic preconditioning and cardioprotection -- 3.1 Acute, early phase, or classical IPC -- 3.2 Late phase or delayed ischemic preconditioning, the second window of protection -- 3.3 Innate immunity and preconditioning --
- 4. Clinically useful applications of ischemic conditioning: distant site ischemic preconditioning and ischemic postconditioning -- 4.1 Remote, distant site, or interorgan preconditioning -- 4.2 Ischemic postconditioning or modified, stuttering, or staccoto reperfusion --
- 5. Cardioprotection induced by pharmacologic conditioning and lifestyle interventions that mimic preconditioning -- 5.1 Pharmacologic preconditioning -- 5.2 Lifestyle modification -- 5.2.1 Caloric restriction -- 5.2.2 Mediterranean diet and other nutritional manipulations -- 5.2.3 Ethanol, resveratrol, and the French paradox -- 5.2.3.1 Mechanisms of resveratrol protection in I/R -- 5.2.3.2 Ethanol consumption and ischemic disease -- 5.2.4 Exercise --
- 6. Cardiovascular risk factors, tachyphylaxis, and the efficacy of pre- and postconditioning -- 6.1 Aging -- 6.2 Obesity, metabolic syndrome, and diabetes -- 6.3 Hypercholesterolemia -- 6.4 Hyperhomocysteinemia -- 6.5 Hypertension -- 6.6 Smoking -- 6.7 Pharmaceutical agents and dietary factors that interfere with preconditioning -- 6.8 The problem of tachyphylaxis to repeated bouts of preconditioning --
- 7. Logical extensions of preconditioning: gene and stem cell therapy for I/R -- 7.1 Gene therapy and I/R -- 7.2 Preconditioning, stem cells, and regenerative medicine --
- Acknowledgments -- References
- Isbn
- 9781615045853
- Label
- Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection
- Title
- Cell survival programs and ischemia/reperfusion
- Title remainder
- hormesis, preconditioning, and cardioprotection
- Statement of responsibility
- Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis
- Language
- eng
- Summary
- The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects of ischemia/reperfusion (I/R). We begin with a discussion of the concept of hormesis (a term used most extensively in the toxicologic literature which refers to biphasic cellular responses that depend on concentration or intensity of a stimulus), review the seminal studies that led to the discovery of the cardioprotective effects of ischemic preconditioning, and outline its therapeutic potential (Chapter 1). This is followed by a summary of our current understanding of the mechanisms of I/R injury (Chapter 2 ), as this provides several points of intervention in limiting postischemic tissue injury that may be targeted by the adaptive programs invoked by conditioning stimuli. Chapters 3 and 4 focus on the mechanisms underlying ischemic pre-, post-, and remote conditioning, which establishes the mechanistic rationale for development of pharmacologic conditioning strategies that may mimic the remarkably powerful effects of ischemic conditioning (and are covered in Chapter 5 ). Lifestyle interventions, including exercise, caloric restriction, and consumption of alcoholic beverages and/or phytochemicals, that may induce hormetic responses will also be reviewed in this chapter. While the promise for conditioning as a therapeutic approach is enormous, there are obstacles to its practical application in patients, which are covered in Chapter 6 . The final chapter (Chapter 7 ) examines the extension of our mechanistic understanding of the signaling pathways invoked by conditioning stimuli into the realm of gene therapy and to the preservation of stem cell viability in the harsh ischemic environment as natural translational outgrowths of preconditioning into therapeutics
- Additional physical form
- Also available in print.
- Cataloging source
- CaBNVSL
- http://library.link/vocab/creatorName
- Krenz, Maike
- Dewey number
- 616.13
- Illustrations
- illustrations
- Index
- no index present
- LC call number
- RB144
- LC item number
- .K743 2013
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- abstracts summaries
- bibliography
- http://library.link/vocab/relatedWorkOrContributorName
-
- Baines, Christopher.
- Kalogeris, Theodore.
- Korthuis, Ronald J.
- http://library.link/vocab/subjectName
-
- Ischemia
- Reperfusion (Physiology)
- Cells
- Ischemia
- Reperfusion
- Cells
- Target audience
-
- adult
- specialized
- Label
- Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection, Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis, (electronic book)
- Note
- Part of: Colloquium digital library of life sciences
- Bibliography note
- Includes bibliographical references (pages 73-122)
- Color
- multicolored
- Contents
-
- 1. Hormesis and preconditioning defined --1.1 Hormesis: definition and characteristics -- 1.2 Ischemic conditioning is a specific type of hormetic response -- 1.3 Chemical hormesis and pharmacologic conditioning --
- 2. Mechanisms of ischemia/reperfusion injury -- 2.1 General features of ischemia/reperfusion (I/R) -- 2.2 Ischemic versus reperfusion components of total tissue injury induced by I/R -- 2.2.1 Mechanisms of ischemic injury -- 2.2.2 Pathogenesis of reperfusion injury -- 2.2.3 Oxidative/nitrosative stress -- 2.2.4 Inflammation contributes to reperfusion injury -- 2.3 Risk factors for I/R -- 2.4 Why pursue preconditioning as a therapeutic option in I/R? --
- 3. Ischemic preconditioning and cardioprotection -- 3.1 Acute, early phase, or classical IPC -- 3.2 Late phase or delayed ischemic preconditioning, the second window of protection -- 3.3 Innate immunity and preconditioning --
- 4. Clinically useful applications of ischemic conditioning: distant site ischemic preconditioning and ischemic postconditioning -- 4.1 Remote, distant site, or interorgan preconditioning -- 4.2 Ischemic postconditioning or modified, stuttering, or staccoto reperfusion --
- 5. Cardioprotection induced by pharmacologic conditioning and lifestyle interventions that mimic preconditioning -- 5.1 Pharmacologic preconditioning -- 5.2 Lifestyle modification -- 5.2.1 Caloric restriction -- 5.2.2 Mediterranean diet and other nutritional manipulations -- 5.2.3 Ethanol, resveratrol, and the French paradox -- 5.2.3.1 Mechanisms of resveratrol protection in I/R -- 5.2.3.2 Ethanol consumption and ischemic disease -- 5.2.4 Exercise --
- 6. Cardiovascular risk factors, tachyphylaxis, and the efficacy of pre- and postconditioning -- 6.1 Aging -- 6.2 Obesity, metabolic syndrome, and diabetes -- 6.3 Hypercholesterolemia -- 6.4 Hyperhomocysteinemia -- 6.5 Hypertension -- 6.6 Smoking -- 6.7 Pharmaceutical agents and dietary factors that interfere with preconditioning -- 6.8 The problem of tachyphylaxis to repeated bouts of preconditioning --
- 7. Logical extensions of preconditioning: gene and stem cell therapy for I/R -- 7.1 Gene therapy and I/R -- 7.2 Preconditioning, stem cells, and regenerative medicine --
- Acknowledgments -- References
- Control code
- 201309ISP044
- Dimensions
- unknown
- Extent
- 1 PDF (viii, pages)
- File format
- multiple file formats
- Form of item
- online
- Isbn
- 9781615045853
- Issn
- 2154-5626
- Other control number
- 10.4199/C00090ED1V01Y201309ISP044
- Other physical details
- illustrations.
- Reformatting quality
- access
- Specific material designation
- remote
- Label
- Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection, Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis, (electronic book)
- Note
- Part of: Colloquium digital library of life sciences
- Bibliography note
- Includes bibliographical references (pages 73-122)
- Color
- multicolored
- Contents
-
- 1. Hormesis and preconditioning defined --1.1 Hormesis: definition and characteristics -- 1.2 Ischemic conditioning is a specific type of hormetic response -- 1.3 Chemical hormesis and pharmacologic conditioning --
- 2. Mechanisms of ischemia/reperfusion injury -- 2.1 General features of ischemia/reperfusion (I/R) -- 2.2 Ischemic versus reperfusion components of total tissue injury induced by I/R -- 2.2.1 Mechanisms of ischemic injury -- 2.2.2 Pathogenesis of reperfusion injury -- 2.2.3 Oxidative/nitrosative stress -- 2.2.4 Inflammation contributes to reperfusion injury -- 2.3 Risk factors for I/R -- 2.4 Why pursue preconditioning as a therapeutic option in I/R? --
- 3. Ischemic preconditioning and cardioprotection -- 3.1 Acute, early phase, or classical IPC -- 3.2 Late phase or delayed ischemic preconditioning, the second window of protection -- 3.3 Innate immunity and preconditioning --
- 4. Clinically useful applications of ischemic conditioning: distant site ischemic preconditioning and ischemic postconditioning -- 4.1 Remote, distant site, or interorgan preconditioning -- 4.2 Ischemic postconditioning or modified, stuttering, or staccoto reperfusion --
- 5. Cardioprotection induced by pharmacologic conditioning and lifestyle interventions that mimic preconditioning -- 5.1 Pharmacologic preconditioning -- 5.2 Lifestyle modification -- 5.2.1 Caloric restriction -- 5.2.2 Mediterranean diet and other nutritional manipulations -- 5.2.3 Ethanol, resveratrol, and the French paradox -- 5.2.3.1 Mechanisms of resveratrol protection in I/R -- 5.2.3.2 Ethanol consumption and ischemic disease -- 5.2.4 Exercise --
- 6. Cardiovascular risk factors, tachyphylaxis, and the efficacy of pre- and postconditioning -- 6.1 Aging -- 6.2 Obesity, metabolic syndrome, and diabetes -- 6.3 Hypercholesterolemia -- 6.4 Hyperhomocysteinemia -- 6.5 Hypertension -- 6.6 Smoking -- 6.7 Pharmaceutical agents and dietary factors that interfere with preconditioning -- 6.8 The problem of tachyphylaxis to repeated bouts of preconditioning --
- 7. Logical extensions of preconditioning: gene and stem cell therapy for I/R -- 7.1 Gene therapy and I/R -- 7.2 Preconditioning, stem cells, and regenerative medicine --
- Acknowledgments -- References
- Control code
- 201309ISP044
- Dimensions
- unknown
- Extent
- 1 PDF (viii, pages)
- File format
- multiple file formats
- Form of item
- online
- Isbn
- 9781615045853
- Issn
- 2154-5626
- Other control number
- 10.4199/C00090ED1V01Y201309ISP044
- Other physical details
- illustrations.
- Reformatting quality
- access
- Specific material designation
- remote
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.liverpool.ac.uk/portal/Cell-survival-programs-and-ischemiareperfusion-/CEeRwLNdO5U/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.liverpool.ac.uk/portal/Cell-survival-programs-and-ischemiareperfusion-/CEeRwLNdO5U/">Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection, Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis, (electronic book)</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.liverpool.ac.uk/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.liverpool.ac.uk/">University of Liverpool</a></span></span></span></span></div>
