Coverart for item
The Resource Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection, Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis, (electronic book)

Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection, Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis, (electronic book)

Label
Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection
Title
Cell survival programs and ischemia/reperfusion
Title remainder
hormesis, preconditioning, and cardioprotection
Statement of responsibility
Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis
Creator
Contributor
Author
Subject
Language
eng
Summary
The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects of ischemia/reperfusion (I/R). We begin with a discussion of the concept of hormesis (a term used most extensively in the toxicologic literature which refers to biphasic cellular responses that depend on concentration or intensity of a stimulus), review the seminal studies that led to the discovery of the cardioprotective effects of ischemic preconditioning, and outline its therapeutic potential (Chapter 1). This is followed by a summary of our current understanding of the mechanisms of I/R injury (Chapter 2 ), as this provides several points of intervention in limiting postischemic tissue injury that may be targeted by the adaptive programs invoked by conditioning stimuli. Chapters 3 and 4 focus on the mechanisms underlying ischemic pre-, post-, and remote conditioning, which establishes the mechanistic rationale for development of pharmacologic conditioning strategies that may mimic the remarkably powerful effects of ischemic conditioning (and are covered in Chapter 5 ). Lifestyle interventions, including exercise, caloric restriction, and consumption of alcoholic beverages and/or phytochemicals, that may induce hormetic responses will also be reviewed in this chapter. While the promise for conditioning as a therapeutic approach is enormous, there are obstacles to its practical application in patients, which are covered in Chapter 6 . The final chapter (Chapter 7 ) examines the extension of our mechanistic understanding of the signaling pathways invoked by conditioning stimuli into the realm of gene therapy and to the preservation of stem cell viability in the harsh ischemic environment as natural translational outgrowths of preconditioning into therapeutics
Member of
Additional physical form
Also available in print.
Cataloging source
CaBNVSL
http://library.link/vocab/creatorName
Krenz, Maike
Dewey number
616.13
Illustrations
illustrations
Index
no index present
LC call number
RB144
LC item number
.K743 2013
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Baines, Christopher.
  • Kalogeris, Theodore.
  • Korthuis, Ronald J.
http://library.link/vocab/subjectName
  • Ischemia
  • Reperfusion (Physiology)
  • Cells
  • Ischemia
  • Reperfusion
  • Cells
Target audience
  • adult
  • specialized
Label
Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection, Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis, (electronic book)
Instantiates
Publication
Note
Part of: Colloquium digital library of life sciences
Bibliography note
Includes bibliographical references (pages 73-122)
Color
multicolored
Contents
  • 1. Hormesis and preconditioning defined --1.1 Hormesis: definition and characteristics -- 1.2 Ischemic conditioning is a specific type of hormetic response -- 1.3 Chemical hormesis and pharmacologic conditioning --
  • 2. Mechanisms of ischemia/reperfusion injury -- 2.1 General features of ischemia/reperfusion (I/R) -- 2.2 Ischemic versus reperfusion components of total tissue injury induced by I/R -- 2.2.1 Mechanisms of ischemic injury -- 2.2.2 Pathogenesis of reperfusion injury -- 2.2.3 Oxidative/nitrosative stress -- 2.2.4 Inflammation contributes to reperfusion injury -- 2.3 Risk factors for I/R -- 2.4 Why pursue preconditioning as a therapeutic option in I/R? --
  • 3. Ischemic preconditioning and cardioprotection -- 3.1 Acute, early phase, or classical IPC -- 3.2 Late phase or delayed ischemic preconditioning, the second window of protection -- 3.3 Innate immunity and preconditioning --
  • 4. Clinically useful applications of ischemic conditioning: distant site ischemic preconditioning and ischemic postconditioning -- 4.1 Remote, distant site, or interorgan preconditioning -- 4.2 Ischemic postconditioning or modified, stuttering, or staccoto reperfusion --
  • 5. Cardioprotection induced by pharmacologic conditioning and lifestyle interventions that mimic preconditioning -- 5.1 Pharmacologic preconditioning -- 5.2 Lifestyle modification -- 5.2.1 Caloric restriction -- 5.2.2 Mediterranean diet and other nutritional manipulations -- 5.2.3 Ethanol, resveratrol, and the French paradox -- 5.2.3.1 Mechanisms of resveratrol protection in I/R -- 5.2.3.2 Ethanol consumption and ischemic disease -- 5.2.4 Exercise --
  • 6. Cardiovascular risk factors, tachyphylaxis, and the efficacy of pre- and postconditioning -- 6.1 Aging -- 6.2 Obesity, metabolic syndrome, and diabetes -- 6.3 Hypercholesterolemia -- 6.4 Hyperhomocysteinemia -- 6.5 Hypertension -- 6.6 Smoking -- 6.7 Pharmaceutical agents and dietary factors that interfere with preconditioning -- 6.8 The problem of tachyphylaxis to repeated bouts of preconditioning --
  • 7. Logical extensions of preconditioning: gene and stem cell therapy for I/R -- 7.1 Gene therapy and I/R -- 7.2 Preconditioning, stem cells, and regenerative medicine --
  • Acknowledgments -- References
Control code
201309ISP044
Dimensions
unknown
Extent
1 PDF (viii, pages)
File format
multiple file formats
Form of item
online
Isbn
9781615045853
Issn
2154-5626
Other control number
10.4199/C00090ED1V01Y201309ISP044
Other physical details
illustrations.
Reformatting quality
access
Specific material designation
remote
Label
Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection, Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis, (electronic book)
Publication
Note
Part of: Colloquium digital library of life sciences
Bibliography note
Includes bibliographical references (pages 73-122)
Color
multicolored
Contents
  • 1. Hormesis and preconditioning defined --1.1 Hormesis: definition and characteristics -- 1.2 Ischemic conditioning is a specific type of hormetic response -- 1.3 Chemical hormesis and pharmacologic conditioning --
  • 2. Mechanisms of ischemia/reperfusion injury -- 2.1 General features of ischemia/reperfusion (I/R) -- 2.2 Ischemic versus reperfusion components of total tissue injury induced by I/R -- 2.2.1 Mechanisms of ischemic injury -- 2.2.2 Pathogenesis of reperfusion injury -- 2.2.3 Oxidative/nitrosative stress -- 2.2.4 Inflammation contributes to reperfusion injury -- 2.3 Risk factors for I/R -- 2.4 Why pursue preconditioning as a therapeutic option in I/R? --
  • 3. Ischemic preconditioning and cardioprotection -- 3.1 Acute, early phase, or classical IPC -- 3.2 Late phase or delayed ischemic preconditioning, the second window of protection -- 3.3 Innate immunity and preconditioning --
  • 4. Clinically useful applications of ischemic conditioning: distant site ischemic preconditioning and ischemic postconditioning -- 4.1 Remote, distant site, or interorgan preconditioning -- 4.2 Ischemic postconditioning or modified, stuttering, or staccoto reperfusion --
  • 5. Cardioprotection induced by pharmacologic conditioning and lifestyle interventions that mimic preconditioning -- 5.1 Pharmacologic preconditioning -- 5.2 Lifestyle modification -- 5.2.1 Caloric restriction -- 5.2.2 Mediterranean diet and other nutritional manipulations -- 5.2.3 Ethanol, resveratrol, and the French paradox -- 5.2.3.1 Mechanisms of resveratrol protection in I/R -- 5.2.3.2 Ethanol consumption and ischemic disease -- 5.2.4 Exercise --
  • 6. Cardiovascular risk factors, tachyphylaxis, and the efficacy of pre- and postconditioning -- 6.1 Aging -- 6.2 Obesity, metabolic syndrome, and diabetes -- 6.3 Hypercholesterolemia -- 6.4 Hyperhomocysteinemia -- 6.5 Hypertension -- 6.6 Smoking -- 6.7 Pharmaceutical agents and dietary factors that interfere with preconditioning -- 6.8 The problem of tachyphylaxis to repeated bouts of preconditioning --
  • 7. Logical extensions of preconditioning: gene and stem cell therapy for I/R -- 7.1 Gene therapy and I/R -- 7.2 Preconditioning, stem cells, and regenerative medicine --
  • Acknowledgments -- References
Control code
201309ISP044
Dimensions
unknown
Extent
1 PDF (viii, pages)
File format
multiple file formats
Form of item
online
Isbn
9781615045853
Issn
2154-5626
Other control number
10.4199/C00090ED1V01Y201309ISP044
Other physical details
illustrations.
Reformatting quality
access
Specific material designation
remote

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