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The Resource Cells and biomaterials for intervertebral disc regeneration, Sibylle Grad ... [et al.], (electronic book)

Cells and biomaterials for intervertebral disc regeneration, Sibylle Grad ... [et al.], (electronic book)

Label
Cells and biomaterials for intervertebral disc regeneration
Title
Cells and biomaterials for intervertebral disc regeneration
Statement of responsibility
Sibylle Grad ... [et al.]
Contributor
Subject
Language
eng
Summary
Disorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter of controversial discussion. In particular, they hardly can restore normal spine biomechanics and prevent degeneration of adjacent tissues. While degeneration affects all areas of the IVD, the most constant and noticeable changes occur in the gel-like central part, the nucleus pulposus (NP). Recent emphasis has therefore been put in biological ways to regenerate the NP; however, there are a number of obstacles to overcome, considering the exceptional biological and biomechanical environment of this tissue. Different biological approaches such as molecular, gene, and cell based therapies have been investigated and have shown promising results in both in vitro and in vivo studies. Nonetheless, considerable hurdles still exist in their application for IVD regeneration in human patients. The choice of the cells and the choice of the cell carrier suitable for implantation pose major challenges for research and development activities. This lecture recapitulates the basics of IVD structure, function, and degeneration mechanisms. The first part reviews the recent progress in the field of disc and stem cell based regenerative approaches. In the second part, most appropriate biomaterials that have been evaluated as cell or molecule carrier to cope with degenerative disc disease are outlined. The potential and limitations of cell- and biomaterial-based treatment strategies and perspectives for future clinical applications are discussed
Member of
Cataloging source
CaBNvSL
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Grad, Sibylle.
Series statement
  • Synthesis digital library of engineering and computer science
  • Synthesis lectures on tissue engineering
Series volume
5
http://library.link/vocab/subjectName
  • Intervertebral disk
  • Intervertebral disk
Target audience
adult
Label
Cells and biomaterials for intervertebral disc regeneration, Sibylle Grad ... [et al.], (electronic book)
Instantiates
Publication
Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references (p. 24-39, 70-94)
Color
multicolored
Contents
  • 1. Cell therapy for nucleus pulposus regeneration / Sibylle Grad and Mauro Alini ; Daisuke Sakai and Joji Mochida -- Introduction -- Intervertebral disc degeneration -- Normal disc structure and function -- Aging and degeneration -- Cell based nucleus pulposus regeneration -- Disc cell based approaches -- Stem cell based approaches -- Limitations and future perspective -- Acknowledgements -- References -- Authors' biographies --
  • 2. Recent advances in biomaterial based tissue engineering for intervertebral disc regeneration / Sunil Mahor, Estelle Collin, Biraja Dash, and Abhay Pandit ; David Eglin -- Introduction -- Intervertebral disc: structure, function and cells -- Anatomy of the intervertebral disc -- Extracellular matrix -- Cells of the intervertebral disc -- Intervertebral disc degeneration: etiology -- Current treatments for degenerative disc disease -- Biomaterials for engineering of intervertebral disc tissue -- Selection of biomaterials -- Biopolymers -- Synthetic polymers -- Polymeric hydrogels for in vitro nucleus pulposus regeneration studies -- Polymeric hydrogels for in vivo nucleus pulposus regeneration -- Future perspectives -- Acknowledgements -- References -- Authors' biographies
Dimensions
unknown
Extent
1 electronic text (viii, 96 p. : ill.)
File format
multiple file formats
Form of item
electronic
Isbn
9781608454655
Level of compression
unknown
Other physical details
digital file. ;
Quality assurance targets
unknown
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat Reader
Label
Cells and biomaterials for intervertebral disc regeneration, Sibylle Grad ... [et al.], (electronic book)
Publication
Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references (p. 24-39, 70-94)
Color
multicolored
Contents
  • 1. Cell therapy for nucleus pulposus regeneration / Sibylle Grad and Mauro Alini ; Daisuke Sakai and Joji Mochida -- Introduction -- Intervertebral disc degeneration -- Normal disc structure and function -- Aging and degeneration -- Cell based nucleus pulposus regeneration -- Disc cell based approaches -- Stem cell based approaches -- Limitations and future perspective -- Acknowledgements -- References -- Authors' biographies --
  • 2. Recent advances in biomaterial based tissue engineering for intervertebral disc regeneration / Sunil Mahor, Estelle Collin, Biraja Dash, and Abhay Pandit ; David Eglin -- Introduction -- Intervertebral disc: structure, function and cells -- Anatomy of the intervertebral disc -- Extracellular matrix -- Cells of the intervertebral disc -- Intervertebral disc degeneration: etiology -- Current treatments for degenerative disc disease -- Biomaterials for engineering of intervertebral disc tissue -- Selection of biomaterials -- Biopolymers -- Synthetic polymers -- Polymeric hydrogels for in vitro nucleus pulposus regeneration studies -- Polymeric hydrogels for in vivo nucleus pulposus regeneration -- Future perspectives -- Acknowledgements -- References -- Authors' biographies
Dimensions
unknown
Extent
1 electronic text (viii, 96 p. : ill.)
File format
multiple file formats
Form of item
electronic
Isbn
9781608454655
Level of compression
unknown
Other physical details
digital file. ;
Quality assurance targets
unknown
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat Reader

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