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The Resource Cellular and molecular approaches to regeneration and repair, Paul A. Lapchak, John H. Zhang, editors

Cellular and molecular approaches to regeneration and repair, Paul A. Lapchak, John H. Zhang, editors

Label
Cellular and molecular approaches to regeneration and repair
Title
Cellular and molecular approaches to regeneration and repair
Statement of responsibility
Paul A. Lapchak, John H. Zhang, editors
Contributor
Subject
Language
eng
Summary
This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery. Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to understand the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential. Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke. Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke
Member of
Cataloging source
EBLCP
Dewey number
  • 571.5/38
  • 610
Index
no index present
LC call number
R857.T55
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Lapchak, Paul A
  • Zhang, J. H.
Series statement
Springer Series in Translational Stroke Research
http://library.link/vocab/subjectName
  • Regenerative medicine
  • Stem cells
Label
Cellular and molecular approaches to regeneration and repair, Paul A. Lapchak, John H. Zhang, editors
Instantiates
Publication
Note
""2.2 Radial Glia-Like Cells (Type-1 Cells) in SGZ""
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • ""Contents""; ""Part I: Stem Cells""; ""Chapter 1: Stroke: Cytoprotection, Repair and Regeneration#x80;#x94;The Continuum of Patient Care""; ""1 Introduction""; ""2 Cellular Measures of Metabolism and Penumbra""; ""2.1 Nicotinamide Adenosine Dinucleotide (NADH) Penumbra Mapping: A New Technique""; ""3 Cytoprotection: What a Time for Intervention?""; ""4 The Stroke Cascade and Current Intervention Attempts Toward Efficacy""; ""5 Critical Targets for Rapid Intervention""; ""5.1 Energy Depletion and Cell Death""; ""5.2 Excitotoxicity""; ""5.3 Oxidative Stress""; ""5.4 Immunotherapy""
  • ""6 Regeneration, Repair and Repopulation""""6.1 What Happens to the Stroke Victim When Penumbra No Longer Exists as a Target for Intervention?""; ""7 Conclusion""; ""References""; ""Chapter 2: Interdisciplinary Advances Towards Understanding and Enhancing the Therapeutic Potential of Stem Cell-Based Therapies for Ischaemic Stroke""; ""1 Introduction""; ""2 Therapeutic Approaches and Evaluation of the Post-stroke Microenvironment""; ""2.1 The Neuroprotective Effect of Stem Cell-Based Therapies""; ""2.1.1 The Complexity of the Ischaemic Cascade""
  • ""2.1.2 Stem Cell-Mediated Neuroprotection""""2.2 Regeneration of Endogenous Tissue by Stem Cells After Ischaemic Stroke""; ""2.2.1 Vascular Remodelling After Stroke""; ""2.2.2 Endogenous Regeneration After Stroke""; ""2.2.3 ECM and Scar Tissue Remodelling""; ""2.3 Immunomodulatory Properties of Candidate Stem Cell-Based Therapies for Ischaemic Stroke""; ""2.3.1 Introduction to Stroke Immunology""; ""2.3.2 Mechanisms of Stem Cell-Mediated Immunomodulation""; ""3 Noninvasive Monitoring of Stem Cells in the Stroke Microenvironment""; ""4 Conclusion""; ""References""
  • ""Chapter 3: Stem Cell Transplants in the Aged Stroke Brain: Microenvironment Factors""""1 Introduction""; ""2 Age Is the Principal Risk Factor for Stroke""; ""3 Stroke Commorbidities""; ""4 Stroke Models Using Aged Animals Are Clinically More Relevant""; ""4.1 Spontaneous Stroke Recovery in Aged Patients and Animals""; ""5 Stroke Therapy in Aged Subjects Using G-CSF""; ""6 Cell Therapy of Stroke Using a Combination Therapy""; ""7 Co-administration of G-CSF and BM-MSC in the Microenvironment of the Post-stroke Aged Rats""
  • ""8 Functional Neurological Recovery and Tissue Repair After Neural Tissue Transplantation""""9 Stem Cell Therapy in Subcortical Stroke. Role of Endogenous Neurogenesis and Aging""; ""10 Mesenchymal Cells Can Be Used as Drug Carriers for Stroke Therapy""; ""11 Angiogenesis After Stroke in the Aged Brains""; ""12 Conclusions""; ""References""; ""Chapter 4: Modulating Endogenous Adult Neural Stem Cells to Improve Regeneration in Stroke Brain""; ""1 Introduction""; ""2 NSCs Responses in Adult Brain Following Stroke""; ""2.1 Radial Glial Cells (Type B Cells) in SVZ""
Control code
SPR1012343410
Dimensions
unknown
Extent
1 online resource (532 pages).
File format
unknown
Form of item
online
Isbn
9783319666785
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-319-66679-2
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • on1012343410
  • (OCoLC)1012343410
Label
Cellular and molecular approaches to regeneration and repair, Paul A. Lapchak, John H. Zhang, editors
Publication
Note
""2.2 Radial Glia-Like Cells (Type-1 Cells) in SGZ""
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • ""Contents""; ""Part I: Stem Cells""; ""Chapter 1: Stroke: Cytoprotection, Repair and Regeneration#x80;#x94;The Continuum of Patient Care""; ""1 Introduction""; ""2 Cellular Measures of Metabolism and Penumbra""; ""2.1 Nicotinamide Adenosine Dinucleotide (NADH) Penumbra Mapping: A New Technique""; ""3 Cytoprotection: What a Time for Intervention?""; ""4 The Stroke Cascade and Current Intervention Attempts Toward Efficacy""; ""5 Critical Targets for Rapid Intervention""; ""5.1 Energy Depletion and Cell Death""; ""5.2 Excitotoxicity""; ""5.3 Oxidative Stress""; ""5.4 Immunotherapy""
  • ""6 Regeneration, Repair and Repopulation""""6.1 What Happens to the Stroke Victim When Penumbra No Longer Exists as a Target for Intervention?""; ""7 Conclusion""; ""References""; ""Chapter 2: Interdisciplinary Advances Towards Understanding and Enhancing the Therapeutic Potential of Stem Cell-Based Therapies for Ischaemic Stroke""; ""1 Introduction""; ""2 Therapeutic Approaches and Evaluation of the Post-stroke Microenvironment""; ""2.1 The Neuroprotective Effect of Stem Cell-Based Therapies""; ""2.1.1 The Complexity of the Ischaemic Cascade""
  • ""2.1.2 Stem Cell-Mediated Neuroprotection""""2.2 Regeneration of Endogenous Tissue by Stem Cells After Ischaemic Stroke""; ""2.2.1 Vascular Remodelling After Stroke""; ""2.2.2 Endogenous Regeneration After Stroke""; ""2.2.3 ECM and Scar Tissue Remodelling""; ""2.3 Immunomodulatory Properties of Candidate Stem Cell-Based Therapies for Ischaemic Stroke""; ""2.3.1 Introduction to Stroke Immunology""; ""2.3.2 Mechanisms of Stem Cell-Mediated Immunomodulation""; ""3 Noninvasive Monitoring of Stem Cells in the Stroke Microenvironment""; ""4 Conclusion""; ""References""
  • ""Chapter 3: Stem Cell Transplants in the Aged Stroke Brain: Microenvironment Factors""""1 Introduction""; ""2 Age Is the Principal Risk Factor for Stroke""; ""3 Stroke Commorbidities""; ""4 Stroke Models Using Aged Animals Are Clinically More Relevant""; ""4.1 Spontaneous Stroke Recovery in Aged Patients and Animals""; ""5 Stroke Therapy in Aged Subjects Using G-CSF""; ""6 Cell Therapy of Stroke Using a Combination Therapy""; ""7 Co-administration of G-CSF and BM-MSC in the Microenvironment of the Post-stroke Aged Rats""
  • ""8 Functional Neurological Recovery and Tissue Repair After Neural Tissue Transplantation""""9 Stem Cell Therapy in Subcortical Stroke. Role of Endogenous Neurogenesis and Aging""; ""10 Mesenchymal Cells Can Be Used as Drug Carriers for Stroke Therapy""; ""11 Angiogenesis After Stroke in the Aged Brains""; ""12 Conclusions""; ""References""; ""Chapter 4: Modulating Endogenous Adult Neural Stem Cells to Improve Regeneration in Stroke Brain""; ""1 Introduction""; ""2 NSCs Responses in Adult Brain Following Stroke""; ""2.1 Radial Glial Cells (Type B Cells) in SVZ""
Control code
SPR1012343410
Dimensions
unknown
Extent
1 online resource (532 pages).
File format
unknown
Form of item
online
Isbn
9783319666785
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-319-66679-2
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • on1012343410
  • (OCoLC)1012343410

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