Coverart for item
The Resource Chemical library design, edited by Joe Zhongxiang Zhou, (electronic book)

Chemical library design, edited by Joe Zhongxiang Zhou, (electronic book)

Label
Chemical library design
Title
Chemical library design
Statement of responsibility
edited by Joe Zhongxiang Zhou
Contributor
Subject
Language
eng
Summary
Chemical library technologies have brought about dramatic changes in the drug discovery process, and, though still evolving, they have become an integral part of ongoing drug discovery research. In Chemical Library Design, experts in the field provide methods and detailed protocols delving into this key process of selecting useful, biologically relevant compounds from large pools of synthesizable candidates. This compendium includes chapters on historical overviews, state-of-the-art methodologies, including structure-based and fragment-based library design, practical software tools, and successful and important applications of chemical library design. As a volume in the popular Methods in Molecular Biology series, the thorough contributions provide the kind of meticulous description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Chemical Library Design is an ideal reference for all scientists seeking the technology needed to aid in the search for new and vital drugs
Member of
Cataloging source
GW5XE
Dewey number
615/.19
Illustrations
illustrations
Index
index present
LC call number
RS419
LC item number
.C54 2011
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Zhou, Joe Zhongxiang
Series statement
Methods in molecular biology,
Series volume
v. 685
http://library.link/vocab/subjectName
  • Combinatorial chemistry
  • Cheminformatics
  • Drugs
  • Combinatorial Chemistry Techniques
  • Designer Drugs
Label
Chemical library design, edited by Joe Zhongxiang Zhou, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Historical overview of chemical library design -- Chemoinformatics and library design -- Molecular library design using multi-objective optimization methods -- A scalable approach to combinatorial library design -- Application of free-Wilson selectivity analysis for combinatorial library design -- Application of QSAR and shape pharmacophore modeling approaches for targeted chemical library design -- Combinatorial library design from reagent pharmacophore fingerprints -- Docking methods for structure-based library design -- Structure-based library design in efficient discovery of novel inhibitors -- Structure-based and property-compliant library design of 11[beta]-HSD1 adamantyl amide inhibitors -- Design of screening collections for successful fragment-based lead discovery -- Fragment-based drug design -- LEAP into the Pfizer Global Virtual Library (PGVL) space: Creation of readily synthesizable design ideas automatically -- The design, annotation, and application of a kinase-targeted library -- PGVL hub: An integrated desktop tool for medicinal chemists to streamline design and synthesis of chemical libraries and singleton compounds -- Design of targeted libraries against the human Chk1 kinase using PGVLhub -- GLARE: A tool for product-oriented design of combinatorial libraries -- CLEVER: A general design tool for combinatorial libraries
Control code
SPR680490860
Dimensions
unknown
Extent
1 online resource (x, 362 pages)
Form of item
online
Isbn
9781607619314
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-60761-931-4
Other physical details
illustrations.
Reproduction note
Electronic resource.
Specific material designation
remote
Label
Chemical library design, edited by Joe Zhongxiang Zhou, (electronic book)
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Historical overview of chemical library design -- Chemoinformatics and library design -- Molecular library design using multi-objective optimization methods -- A scalable approach to combinatorial library design -- Application of free-Wilson selectivity analysis for combinatorial library design -- Application of QSAR and shape pharmacophore modeling approaches for targeted chemical library design -- Combinatorial library design from reagent pharmacophore fingerprints -- Docking methods for structure-based library design -- Structure-based library design in efficient discovery of novel inhibitors -- Structure-based and property-compliant library design of 11[beta]-HSD1 adamantyl amide inhibitors -- Design of screening collections for successful fragment-based lead discovery -- Fragment-based drug design -- LEAP into the Pfizer Global Virtual Library (PGVL) space: Creation of readily synthesizable design ideas automatically -- The design, annotation, and application of a kinase-targeted library -- PGVL hub: An integrated desktop tool for medicinal chemists to streamline design and synthesis of chemical libraries and singleton compounds -- Design of targeted libraries against the human Chk1 kinase using PGVLhub -- GLARE: A tool for product-oriented design of combinatorial libraries -- CLEVER: A general design tool for combinatorial libraries
Control code
SPR680490860
Dimensions
unknown
Extent
1 online resource (x, 362 pages)
Form of item
online
Isbn
9781607619314
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-60761-931-4
Other physical details
illustrations.
Reproduction note
Electronic resource.
Specific material designation
remote

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