Coverart for item
The Resource Developmental genetics of the pharyngeal arch system, Jeffry M. Cesario, André Landin Malt, Juhee Jeong, (electronic book)

Developmental genetics of the pharyngeal arch system, Jeffry M. Cesario, André Landin Malt, Juhee Jeong, (electronic book)

Label
Developmental genetics of the pharyngeal arch system
Title
Developmental genetics of the pharyngeal arch system
Statement of responsibility
Jeffry M. Cesario, André Landin Malt, Juhee Jeong
Creator
Contributor
Author
Subject
Language
eng
Summary
The pharyngeal arches are embryonic structures that develop into the face, neck, a part of the heart, and several endocrine glands in animals. They are thought to have played a key role in vertebrate evolution as their derivatives impact the mode of feeding and breathing. Moreover, perturbation in pharyngeal arch development is associated with several major groups of birth defects in humans. During early embryonic development, cells from all three germ layers come together to assemble the pharyngeal arches. Subsequently, the pharyngeal arches undergo growth, morphogenesis, and cell type differentiation to give rise to musculoskeletal, cardiovascular, neural, and glandular components. These processes are guided by interactions amongst different tissues, via signaling molecules. A large number of genes, with a complex network of regulatory relationships, govern each aspect of pharyngeal arch development. With the advance of molecular genetics tools in model organisms such as mice, we are beginning to understand the molecular and cellular mechanisms underlying development of the pharyngeal arches and related birth defects. This eBook will provide an introduction into development of the pharyngeal arch system, with a detailed discussion on the genetic regulation of this process
Member of
Cataloging source
CaBNVSL
http://library.link/vocab/creatorName
Cesario, Jeffry M
Dewey number
591.4
Illustrations
illustrations
Index
no index present
LC call number
QL639
LC item number
.C473 2015
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Malt, André Landin.
  • Jeong, Juhee.
Series statement
Colloquium series on developmental biology,
Series volume
6
http://library.link/vocab/subjectName
  • Branchial arch
  • Developmental genetics
  • Branchial Region
Target audience
  • adult
  • specialized
Label
Developmental genetics of the pharyngeal arch system, Jeffry M. Cesario, André Landin Malt, Juhee Jeong, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (pages 79-105)
Carrier category
online resource
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type MARC source
rdacontent
Contents
  • 1. Overview of the pharyngeal arch system -- 1.1 The components of the pharyngeal arch system -- 1.1.1 Pharyngeal endoderm -- 1.1.2 Surface ectoderm -- 1.1.3 Neural crest-derived mesenchyme -- 1.1.4 Mesoderm -- 1.1.5 Vascular endothelium -- 1.1.6 Nerves -- 1.2 Derivatives of the pharyngeal arch system -- 1.2.1 1st pharyngeal arch -- 1.2.2 2nd pharyngeal arch (also called hyoid arch) -- 1.2.3 3rd pharyngeal arch -- 1.2.4 4th and 6th pharyngeal arches -- 1.2.5 Pharyngeal endoderm and pouches -- 1.2.6 Pharyngeal clefts -- 1.2.7 Cardiac neural crest and the second heart field -- 1.2.8 Development of the tongue -- 1.3 Tissue interactions regulating pharyngeal arch development -- 1.3.1 Pharyngeal endoderm - ectoderm, neural crest mesenchyme -- 1.3.2 Ectoderm - neural crest mesenchyme -- 1.3.3 Mesodermal mesenchyme - neural crest mesenchyme -- 1.3.4 Neural crest mesenchyme - ectoderm, mesodermal mesenchyme -- 1.3.5 Migrating neural crest - placodal sensory neurons --
  • 2. Signaling pathways that regulate pharyngeal arch development -- 2.1 Hedgehog (Hh) -- 2.1.1 SHH signaling is essential for making a normal face -- 2.1.2 SHH regulates cardiovascular development -- 2.1.3 SHH negatively regulates parathyroid specification -- 2.2 Wingless/int (WNT) -- 2.2.1 Canonical WNT signaling in craniofacial development -- 2.2.2 Canonical WNT signaling in cardiovascular and pharyngeal glands development -- 2.2.3 Non-canonical WNT signaling in pharyngeal arch development -- 2.3 Fibroblast growth factor (FGF) -- 2.3.1 FGF8 from the 1st pharyngeal arch ectoderm is essential to normal craniofacial development -- 2.3.2 FGF signaling in the pharyngeal epithelium regulates neural crest cell migration -- 2.3.3 Several FGF ligands regulate cardiovascular development -- 2.3.4 FGF8 is required for glandular and neural development associated with the pharyngeal arches -- 2.3.5 Crkl (v-crk sarcoma virus CT10 oncogene homolog (avian)-like), Encoding an adaptor protein of the FGF pathway, is one of the 22q11 deletion syndrome genes -- 2.3.6 Ras-ERK pathway regulates pharyngeal arch development -- 2.4 Transforming growth factor b (TGFb) -- 2.4.1 BMP4 regulates the growth and patterning of the 1st pharyngeal arch -- 2.4.2 Additional evidence for the regulation of 1st pharyngeal arch development by TGFb superfamily signaling -- 2.4.3 TGFb signaling in cardiovascular development -- 2.4.4 TGFb signaling in glandular development -- 2.4.5 Inhibitors of BMP are important for pharyngeal arch development -- 2.5 Endothelin (EDN) -- 2.5.1 EDN signaling specifies lower jaw identity within the pharyngeal arch -- 2.5.2 EDN signaling regulates remodeling of the pharyngeal arch arteries -- 2.5.3 EDN signaling in glandular development -- 2.6 Retinoic acid (RA) -- 2.6.1 RA signaling is essential for multiple aspects of the caudal pharyngeal arch development -- 2.6.2 Excess RA signaling also has deleterious effects on pharyngeal arch development --
  • 3. Transcriptional network that regulates pharyngeal arch development -- 3.1 Homeobox (HOX) -- 3.1.1 Hox code patterns the pharygneal arch system along the antero-posterior axis -- 3.1.2 Hoxa2 is a selector gene for the 2nd pharyngeal arch identity -- 3.1.3 Expanded role of Hox genes in inter-arch patterning -- 3.1.4 Hox genes in cardiovascular development -- 3.1.5 Hoxa3 is crucial to development of the pharyngeal endoderm-derived organs -- 3.2 Distal-less homeobox (DLX) -- 3.2.1 Dlx code patterns the 1st pharyngeal arch into the upper jaw and the lower jaw subdivisions -- 3.2.2 Dlx5/6 in head muscle development -- 3.3 LIM homeobox (LHX) -- 3.3.1 ISL1 regulates Fgf8 and Shh expression in the pharyngeal arch epithelium -- 3.3.2 Lhx6 and Lhx8 are required for development of the oral structures -- 3.4 Msh homeobox (MSX) -- 3.5 Paired homeobox -- 3.5.1 Gsc is required for development of the lower jaw and the outer/middle ear -- 3.5.2 Prrx, Alx, and Pitx1 mainly regulate development of the lower jaw -- 3.5.3 Pitx2 regulates patterning of the oral ectoderm and development of the pharyngeal mesoderm -- 3.6 Twist family basic helix-loop-helix (bHLH) transcription factors -- 3.6.1 Twist1 is important for the survival and distribution of the cells in the pharyngeal ectomesenchyme -- 3.6.2 Hand2 is a key regulator of the specification and patterning of the lower jaw -- 3.6.3 Hand2 is important for cardiovascular development -- 3.7 Myocyte enhancer factor 2 (MEF2) -- 3.7.1 Mef2c is required for the expression of lower jaw genes in the mandibular arch -- 3.8 T-box (TBX) -- 3.8.1 Tbx1, a 22q11 deletion syndrome gene, is crucial to development of the pharyngeal arch system -- 3.8.2 Tbx1-downstream genetic pathways regulating pharyngeal arch development -- 3.8.3 Tbx2 in the ectomesenchyme regulates cardiovascular development -- 3.9 Ripply -- 3.9.1 Ripply3 is involved in development of the great arteries and multiple glands -- 3.10 Gastrulation brain homeobox 2 (GBX2) -- 3.10.1 Gbx2 is important for development of the 4th pharyngeal arch artery -- 3.11 Paired box (PAX) -- 3.11.1 Pax1 and pax9 regulate development of the pharyngeal glands -- 3.12 Eyes absent (EYA) and SIX -- 3.12.1 Role of Eya1 and Six1 in craniofacial and cardiovascular development -- 3.12.2 Role of Eya1 and Six1 in glandular and neural development -- 3.13 Glial cell missing homolog 2 (GCM2) and Forkhead box N1 (FOXN1) -- 3.13.1 Gcm2 and Foxn1 regulate development of the parathyroid and thymus, respectively --
  • 4. Concluding remarks -- References -- Author biographies
Control code
201503DEB006
Dimensions
unknown
Extent
1 PDF (x, 108 pages)
File format
multiple file formats
Form of item
online
Isbn
9781615046812
Media category
electronic
Media MARC source
isbdmedia
Other control number
10.4199/C00127ED1V01Y201503DEB006
Other physical details
illustrations.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
Developmental genetics of the pharyngeal arch system, Jeffry M. Cesario, André Landin Malt, Juhee Jeong, (electronic book)
Publication
Bibliography note
Includes bibliographical references (pages 79-105)
Carrier category
online resource
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type MARC source
rdacontent
Contents
  • 1. Overview of the pharyngeal arch system -- 1.1 The components of the pharyngeal arch system -- 1.1.1 Pharyngeal endoderm -- 1.1.2 Surface ectoderm -- 1.1.3 Neural crest-derived mesenchyme -- 1.1.4 Mesoderm -- 1.1.5 Vascular endothelium -- 1.1.6 Nerves -- 1.2 Derivatives of the pharyngeal arch system -- 1.2.1 1st pharyngeal arch -- 1.2.2 2nd pharyngeal arch (also called hyoid arch) -- 1.2.3 3rd pharyngeal arch -- 1.2.4 4th and 6th pharyngeal arches -- 1.2.5 Pharyngeal endoderm and pouches -- 1.2.6 Pharyngeal clefts -- 1.2.7 Cardiac neural crest and the second heart field -- 1.2.8 Development of the tongue -- 1.3 Tissue interactions regulating pharyngeal arch development -- 1.3.1 Pharyngeal endoderm - ectoderm, neural crest mesenchyme -- 1.3.2 Ectoderm - neural crest mesenchyme -- 1.3.3 Mesodermal mesenchyme - neural crest mesenchyme -- 1.3.4 Neural crest mesenchyme - ectoderm, mesodermal mesenchyme -- 1.3.5 Migrating neural crest - placodal sensory neurons --
  • 2. Signaling pathways that regulate pharyngeal arch development -- 2.1 Hedgehog (Hh) -- 2.1.1 SHH signaling is essential for making a normal face -- 2.1.2 SHH regulates cardiovascular development -- 2.1.3 SHH negatively regulates parathyroid specification -- 2.2 Wingless/int (WNT) -- 2.2.1 Canonical WNT signaling in craniofacial development -- 2.2.2 Canonical WNT signaling in cardiovascular and pharyngeal glands development -- 2.2.3 Non-canonical WNT signaling in pharyngeal arch development -- 2.3 Fibroblast growth factor (FGF) -- 2.3.1 FGF8 from the 1st pharyngeal arch ectoderm is essential to normal craniofacial development -- 2.3.2 FGF signaling in the pharyngeal epithelium regulates neural crest cell migration -- 2.3.3 Several FGF ligands regulate cardiovascular development -- 2.3.4 FGF8 is required for glandular and neural development associated with the pharyngeal arches -- 2.3.5 Crkl (v-crk sarcoma virus CT10 oncogene homolog (avian)-like), Encoding an adaptor protein of the FGF pathway, is one of the 22q11 deletion syndrome genes -- 2.3.6 Ras-ERK pathway regulates pharyngeal arch development -- 2.4 Transforming growth factor b (TGFb) -- 2.4.1 BMP4 regulates the growth and patterning of the 1st pharyngeal arch -- 2.4.2 Additional evidence for the regulation of 1st pharyngeal arch development by TGFb superfamily signaling -- 2.4.3 TGFb signaling in cardiovascular development -- 2.4.4 TGFb signaling in glandular development -- 2.4.5 Inhibitors of BMP are important for pharyngeal arch development -- 2.5 Endothelin (EDN) -- 2.5.1 EDN signaling specifies lower jaw identity within the pharyngeal arch -- 2.5.2 EDN signaling regulates remodeling of the pharyngeal arch arteries -- 2.5.3 EDN signaling in glandular development -- 2.6 Retinoic acid (RA) -- 2.6.1 RA signaling is essential for multiple aspects of the caudal pharyngeal arch development -- 2.6.2 Excess RA signaling also has deleterious effects on pharyngeal arch development --
  • 3. Transcriptional network that regulates pharyngeal arch development -- 3.1 Homeobox (HOX) -- 3.1.1 Hox code patterns the pharygneal arch system along the antero-posterior axis -- 3.1.2 Hoxa2 is a selector gene for the 2nd pharyngeal arch identity -- 3.1.3 Expanded role of Hox genes in inter-arch patterning -- 3.1.4 Hox genes in cardiovascular development -- 3.1.5 Hoxa3 is crucial to development of the pharyngeal endoderm-derived organs -- 3.2 Distal-less homeobox (DLX) -- 3.2.1 Dlx code patterns the 1st pharyngeal arch into the upper jaw and the lower jaw subdivisions -- 3.2.2 Dlx5/6 in head muscle development -- 3.3 LIM homeobox (LHX) -- 3.3.1 ISL1 regulates Fgf8 and Shh expression in the pharyngeal arch epithelium -- 3.3.2 Lhx6 and Lhx8 are required for development of the oral structures -- 3.4 Msh homeobox (MSX) -- 3.5 Paired homeobox -- 3.5.1 Gsc is required for development of the lower jaw and the outer/middle ear -- 3.5.2 Prrx, Alx, and Pitx1 mainly regulate development of the lower jaw -- 3.5.3 Pitx2 regulates patterning of the oral ectoderm and development of the pharyngeal mesoderm -- 3.6 Twist family basic helix-loop-helix (bHLH) transcription factors -- 3.6.1 Twist1 is important for the survival and distribution of the cells in the pharyngeal ectomesenchyme -- 3.6.2 Hand2 is a key regulator of the specification and patterning of the lower jaw -- 3.6.3 Hand2 is important for cardiovascular development -- 3.7 Myocyte enhancer factor 2 (MEF2) -- 3.7.1 Mef2c is required for the expression of lower jaw genes in the mandibular arch -- 3.8 T-box (TBX) -- 3.8.1 Tbx1, a 22q11 deletion syndrome gene, is crucial to development of the pharyngeal arch system -- 3.8.2 Tbx1-downstream genetic pathways regulating pharyngeal arch development -- 3.8.3 Tbx2 in the ectomesenchyme regulates cardiovascular development -- 3.9 Ripply -- 3.9.1 Ripply3 is involved in development of the great arteries and multiple glands -- 3.10 Gastrulation brain homeobox 2 (GBX2) -- 3.10.1 Gbx2 is important for development of the 4th pharyngeal arch artery -- 3.11 Paired box (PAX) -- 3.11.1 Pax1 and pax9 regulate development of the pharyngeal glands -- 3.12 Eyes absent (EYA) and SIX -- 3.12.1 Role of Eya1 and Six1 in craniofacial and cardiovascular development -- 3.12.2 Role of Eya1 and Six1 in glandular and neural development -- 3.13 Glial cell missing homolog 2 (GCM2) and Forkhead box N1 (FOXN1) -- 3.13.1 Gcm2 and Foxn1 regulate development of the parathyroid and thymus, respectively --
  • 4. Concluding remarks -- References -- Author biographies
Control code
201503DEB006
Dimensions
unknown
Extent
1 PDF (x, 108 pages)
File format
multiple file formats
Form of item
online
Isbn
9781615046812
Media category
electronic
Media MARC source
isbdmedia
Other control number
10.4199/C00127ED1V01Y201503DEB006
Other physical details
illustrations.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

Library Locations

Processing Feedback ...