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The Resource Directed enzyme evolution : advances and applications, Miguel Alcalde, editor

Directed enzyme evolution : advances and applications, Miguel Alcalde, editor

Editor
Contributor
Summary
This book focuses on some of the most significant advances in enzyme engineering that have been achieved through directed evolution and hybrid approaches. On the 25th anniversary of the discovery of directed evolution, this volume is a tribute to the pioneers of this thrilling research field, and at the same time provides a comprehensive overview of current research and the state of the art. Directed molecular evolution has become the most reliable and robust method to tailor enzymes, metabolic pathways or even whole microorganisms with improved traits. By mirroring the Darwinian algorithm of natural selection on a laboratory scale, new biomolecules of invaluable biotechnological interest can now be engineered in a manner that surpasses the boundaries of nature. The volume is divided into two sections, the first of which provides an update on recent successful cases of enzyme ensembles from different areas of the biotechnological spectrum, including tryptophan synthases, unspecific peroxygenases, phytases, therapeutic enzymes, stereoselective enzymes and CO2-fixing enzymes. This section also provides information on the directed evolution of whole cells. The second section of the book summarizes a variety of the most applicable methods for library creation, together with the future trends aimed at bringing together directed evolution and in silico/computational enzyme design and ancestral resurrection
Language
eng
Work
Publication
Extent
1 online resource.
Contents
  • 1. Directed evolution for Opsin Engineering (Prof. Frances H. Arnold, Caltech, USA)
  • 2. Directed evolution for enzyme enantio-selectivity (Prof. Manfred T. Reetz, Max-Planck-Institut für Kohlenforschung, Germany)
  • 3. Directed evolution for fuels and chemicals (Prof. Huimin Zhao, University of Urbana-Champaign, Illinois, USA)
  • 4. Directed evolution for cancer biopharmaceuticals (Prof. Dane Wittrup, MIT, USA)
  • 5. Directed evolution of the ligninolytic consortium (Prof. Miguel Alcalde, Institute of Catalysis, CSIC, Madrid, Spain)
  • 6. Directed evolution for engineering of metabolic pathways (Prof. Claudia Schmidt-Dannert, University of Minnesota, USA)
  • 7. Directed evolution and metagenomics (Prof. Kenneth N. Timmis, Technische Universität Braunschweig, Germany)
  • 8. Directed evolution and protein evolvability (Prof. Jesse Bloom, Fred Hutchinson Cancer Research Center, Seattle, USA)
  • 9. Directed evolution for understanding natural evolution (Prof. Dan S. Tawfik, Weizmann Institute of Science, Rehovot, Israel)
  • 10. Diversity methods for directed evolution (Prof. Ullrich Schwaneberg, RWTH-Aachen University, Germany)
  • 11. Ancestral enzymes, evolution and resurrection (Prof. Jose Manuel Sanchez Ruiz, Universidad de Granada, Spain)
  • 12. Directed evolution and computational protein algorithms (Prof. Victor Guallar, Barcelona Supercomputing Center, Spain)
Isbn
9783319504131
Instance
Label
Directed enzyme evolution : advances and applications
Title
Directed enzyme evolution
Title remainder
advances and applications
Statement of responsibility
Miguel Alcalde, editor
Contributor
Editor
Subject
Language
eng
Summary
This book focuses on some of the most significant advances in enzyme engineering that have been achieved through directed evolution and hybrid approaches. On the 25th anniversary of the discovery of directed evolution, this volume is a tribute to the pioneers of this thrilling research field, and at the same time provides a comprehensive overview of current research and the state of the art. Directed molecular evolution has become the most reliable and robust method to tailor enzymes, metabolic pathways or even whole microorganisms with improved traits. By mirroring the Darwinian algorithm of natural selection on a laboratory scale, new biomolecules of invaluable biotechnological interest can now be engineered in a manner that surpasses the boundaries of nature. The volume is divided into two sections, the first of which provides an update on recent successful cases of enzyme ensembles from different areas of the biotechnological spectrum, including tryptophan synthases, unspecific peroxygenases, phytases, therapeutic enzymes, stereoselective enzymes and CO2-fixing enzymes. This section also provides information on the directed evolution of whole cells. The second section of the book summarizes a variety of the most applicable methods for library creation, together with the future trends aimed at bringing together directed evolution and in silico/computational enzyme design and ancestral resurrection
Member of
Cataloging source
N$T
Dewey number
660.6/34
Index
no index present
LC call number
QH442
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Alcalde, Miguel
http://library.link/vocab/subjectName
  • Molecular evolution
  • Enzymes
  • Protein engineering
Label
Directed enzyme evolution : advances and applications, Miguel Alcalde, editor
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1. Directed evolution for Opsin Engineering (Prof. Frances H. Arnold, Caltech, USA) -- 2. Directed evolution for enzyme enantio-selectivity (Prof. Manfred T. Reetz, Max-Planck-Institut für Kohlenforschung, Germany) -- 3. Directed evolution for fuels and chemicals (Prof. Huimin Zhao, University of Urbana-Champaign, Illinois, USA) -- 4. Directed evolution for cancer biopharmaceuticals (Prof. Dane Wittrup, MIT, USA) -- 5. Directed evolution of the ligninolytic consortium (Prof. Miguel Alcalde, Institute of Catalysis, CSIC, Madrid, Spain) -- 6. Directed evolution for engineering of metabolic pathways (Prof. Claudia Schmidt-Dannert, University of Minnesota, USA) -- 7. Directed evolution and metagenomics (Prof. Kenneth N. Timmis, Technische Universität Braunschweig, Germany) -- 8. Directed evolution and protein evolvability (Prof. Jesse Bloom, Fred Hutchinson Cancer Research Center, Seattle, USA) -- 9. Directed evolution for understanding natural evolution (Prof. Dan S. Tawfik, Weizmann Institute of Science, Rehovot, Israel) -- 10. Diversity methods for directed evolution (Prof. Ullrich Schwaneberg, RWTH-Aachen University, Germany) -- 11. Ancestral enzymes, evolution and resurrection (Prof. Jose Manuel Sanchez Ruiz, Universidad de Granada, Spain) -- 12. Directed evolution and computational protein algorithms (Prof. Victor Guallar, Barcelona Supercomputing Center, Spain)
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9783319504131
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
ocn972900340
Label
Directed enzyme evolution : advances and applications, Miguel Alcalde, editor
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
1. Directed evolution for Opsin Engineering (Prof. Frances H. Arnold, Caltech, USA) -- 2. Directed evolution for enzyme enantio-selectivity (Prof. Manfred T. Reetz, Max-Planck-Institut für Kohlenforschung, Germany) -- 3. Directed evolution for fuels and chemicals (Prof. Huimin Zhao, University of Urbana-Champaign, Illinois, USA) -- 4. Directed evolution for cancer biopharmaceuticals (Prof. Dane Wittrup, MIT, USA) -- 5. Directed evolution of the ligninolytic consortium (Prof. Miguel Alcalde, Institute of Catalysis, CSIC, Madrid, Spain) -- 6. Directed evolution for engineering of metabolic pathways (Prof. Claudia Schmidt-Dannert, University of Minnesota, USA) -- 7. Directed evolution and metagenomics (Prof. Kenneth N. Timmis, Technische Universität Braunschweig, Germany) -- 8. Directed evolution and protein evolvability (Prof. Jesse Bloom, Fred Hutchinson Cancer Research Center, Seattle, USA) -- 9. Directed evolution for understanding natural evolution (Prof. Dan S. Tawfik, Weizmann Institute of Science, Rehovot, Israel) -- 10. Diversity methods for directed evolution (Prof. Ullrich Schwaneberg, RWTH-Aachen University, Germany) -- 11. Ancestral enzymes, evolution and resurrection (Prof. Jose Manuel Sanchez Ruiz, Universidad de Granada, Spain) -- 12. Directed evolution and computational protein algorithms (Prof. Victor Guallar, Barcelona Supercomputing Center, Spain)
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9783319504131
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
ocn972900340

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