Coverart for item
The Resource Discovery and development of therapeutics from natural products against neglected tropical diseases, edited by Goutam Brahmachari

Discovery and development of therapeutics from natural products against neglected tropical diseases, edited by Goutam Brahmachari

Label
Discovery and development of therapeutics from natural products against neglected tropical diseases
Title
Discovery and development of therapeutics from natural products against neglected tropical diseases
Statement of responsibility
edited by Goutam Brahmachari
Contributor
Editor
Subject
Language
eng
Summary
Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases
Member of
Cataloging source
N$T
Dewey number
616.462061
Index
no index present
LC call number
RC661.A1
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Brahmachari, Goutam
Series statement
Natural product drug discovery
http://library.link/vocab/subjectName
  • Hypoglycemic agents
  • Materia medica.
Label
Discovery and development of therapeutics from natural products against neglected tropical diseases, edited by Goutam Brahmachari
Instantiates
Publication
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Front Cover; Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases; Copyright Page; Dedication; Contents; List of Contributors; Editor Biography; Foreword; Preface; 1 Therapeutics from natural products against neglected tropical diseases: an overview; 1.1 Introduction; 1.2 An overview of the book; 1.3 Concluding remarks; 2 Marine natural products as strategic prototypes in the development of a new generation of antimalarial agents; 2.1 Introduction; 2.2 Antimalarial marine natural products; 2.2.1 Phenolic compounds and polyketides
  • 2.2.2 Terpenoids2.2.3 Endoperoxides and polyethers; 2.2.4 Alkaloids; 2.2.5 Peptides and depsipeptides; 2.2.6 Phosphotriesters; 2.3 Concluding remarks; List of abbreviations; References; Further reading; 3 Sesquiterpene lactones: a versatile class of structurally diverse natural products and their semisynthetic analogs as pot...; 3.1 Introduction; 3.2 Antimalarial potential of plant derived sesquiterpene lactones; 3.2.1 Artemisinin and its C-12 oxa (ether/ester) derivatives; 3.2.1.1 Synthesis of C-12 carba-derivatives of artemisinin
  • 3.2.1.2 Synthesis of C-13 substituted derivatives of artemisinin from artemisitene3.2.1.3 Artemisinin dimers, trimers, and tetramers: novel leads in drug discovery; 3.2.1.4 Synthesis of artemisinin dimers; 3.2.1.5 Synthesis of artemisinin trimers and tetramers; 3.2.2 Germacranolides, guaianolides, and pseudoguiainolides antimalarials SLs; 3.2.2.1 Germacranolides; 3.2.2.2 Guaianolides and pseudoguaianolides; 3.2.3 Miscellaneous antimalarial sesquiterpene lactones; 3.3 Structural-activity relationships of sesquiterpene lactones; 3.4 Concluding remarks; Acknowledgments; List of abbreviations
  • 4.6 Natural sources of quinoline alkaloids with antiparasitic activity4.7 Synthetic efforts for targeted quinoline compounds; 4.7.1 Synthesis of polyfunctionalized quinolines from unsubstituted anilines: Route A; 4.7.2 Synthesis of polyfunctionalized quinolines from ortho-substituted anilines: Route B; 4.8 Quinoline compounds as antitrypanosomal agents; 4.8.1 Simple polyfunctionalized quinolines; 4.8.2 Polycyclic quinoline molecules; 4.9 Concluding remarks; Acknowledgment; List of abbreviations; References; Further reading
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9780128157244
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
Label
Discovery and development of therapeutics from natural products against neglected tropical diseases, edited by Goutam Brahmachari
Publication
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Front Cover; Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases; Copyright Page; Dedication; Contents; List of Contributors; Editor Biography; Foreword; Preface; 1 Therapeutics from natural products against neglected tropical diseases: an overview; 1.1 Introduction; 1.2 An overview of the book; 1.3 Concluding remarks; 2 Marine natural products as strategic prototypes in the development of a new generation of antimalarial agents; 2.1 Introduction; 2.2 Antimalarial marine natural products; 2.2.1 Phenolic compounds and polyketides
  • 2.2.2 Terpenoids2.2.3 Endoperoxides and polyethers; 2.2.4 Alkaloids; 2.2.5 Peptides and depsipeptides; 2.2.6 Phosphotriesters; 2.3 Concluding remarks; List of abbreviations; References; Further reading; 3 Sesquiterpene lactones: a versatile class of structurally diverse natural products and their semisynthetic analogs as pot...; 3.1 Introduction; 3.2 Antimalarial potential of plant derived sesquiterpene lactones; 3.2.1 Artemisinin and its C-12 oxa (ether/ester) derivatives; 3.2.1.1 Synthesis of C-12 carba-derivatives of artemisinin
  • 3.2.1.2 Synthesis of C-13 substituted derivatives of artemisinin from artemisitene3.2.1.3 Artemisinin dimers, trimers, and tetramers: novel leads in drug discovery; 3.2.1.4 Synthesis of artemisinin dimers; 3.2.1.5 Synthesis of artemisinin trimers and tetramers; 3.2.2 Germacranolides, guaianolides, and pseudoguiainolides antimalarials SLs; 3.2.2.1 Germacranolides; 3.2.2.2 Guaianolides and pseudoguaianolides; 3.2.3 Miscellaneous antimalarial sesquiterpene lactones; 3.3 Structural-activity relationships of sesquiterpene lactones; 3.4 Concluding remarks; Acknowledgments; List of abbreviations
  • 4.6 Natural sources of quinoline alkaloids with antiparasitic activity4.7 Synthetic efforts for targeted quinoline compounds; 4.7.1 Synthesis of polyfunctionalized quinolines from unsubstituted anilines: Route A; 4.7.2 Synthesis of polyfunctionalized quinolines from ortho-substituted anilines: Route B; 4.8 Quinoline compounds as antitrypanosomal agents; 4.8.1 Simple polyfunctionalized quinolines; 4.8.2 Polycyclic quinoline molecules; 4.9 Concluding remarks; Acknowledgment; List of abbreviations; References; Further reading
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9780128157244
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote

Library Locations

Processing Feedback ...