Coverart for item
The Resource Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado, (electronic book)

Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado, (electronic book)

Label
Drug targeting : strategies, principles, and applications
Title
Drug targeting
Title remainder
strategies, principles, and applications
Statement of responsibility
edited by G.E. Francis and Cristina Delgado
Contributor
Subject
Language
eng
Summary
Annotation
Member of
Cataloging source
N$T
Dewey number
615/.7
Illustrations
illustrations
Index
index present
LC call number
RM301.63
LC item number
.D785 2000
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Francis, G. E
  • Delgado, Cristina
Series statement
Methods in molecular medicine
Series volume
25
http://library.link/vocab/subjectName
  • Drug delivery systems
  • Drug carriers (Pharmacy)
  • MEDICAL
  • Electronic books
Summary expansion
G.E. Francis and Cristina Delgado have assembled a comprehensive collection of leading-edge protocols for drug targeting studies. In addition to the detailed step-by-step instruction, the protocols review the principal current targeting strategies, discuss how to build the constructs, examine theoretical considerations relevant to solid tumors, and describe experimental and clinical applications of targeted drug delivery systems. Also present are new chemical and biological approaches to the preparation of targeted biopharmaceuticals, including ribonuclease-antibody chimeras, bispecific antibodies, enzyme-antibody conjugates, and folate-bearing conjugates. Applications include the targeting of myocardial infarctions using liposomal systems, the use of monoclonal antibodies to target malaria and HIV-infected cells, the targeting of fusion proteins to leukemias and lymphomas, and the use of antioxidant enzyme-antibody conjugates to target the pulmonary endothelium. Comprehensive and innovative, Drug Targeting: Strategies, Principles, and Applications documents in practical detail the major new chemical and biological targeting methods now being used to produce today's emerging rich array of novel diagnostic agents and promising biopharmaceuticals
Label
Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Color
multicolored
Contents
pt. 1. Strategies -- Chemical construction of immunotoxins -- Construction of ribonuclease-antibody conjugates for selective cytotoxicity -- Intracellular targeting using bispecific antibodies -- Antibody conjugation methods for active targeting of liposomes -- Folate as a targeting device for proteins utilizing folate receptor-mediated endocytosis -- Preparation of recombinant RNase single-chain antibody fusion proteins -- pt. 2. Theoretical aspects -- Practical considerations in the exploitation of passive tumor targeting -- Effect of dose, molecular size, and binding affinity on uptake of antibodies -- Inhibition of tumor blood flow -- pt. 3. Applications -- Targeting in myocardial infarction -- Targeting HIV-infected cells -- Making fusion toxins to targetleukemia and lymphoma -- Antibody-bearing liposomes as chloroquine vehicles in treatment of murine malaria -- Immunotargeting of catalase to the pulmonary vascular endothelium -- Targeted gene transfer: a practical guide based on experience with lipid-based plasmid delivery systems
Control code
SPR49851566
Dimensions
unknown
Extent
1 online resource (x, 318 p.)
Form of item
online
Isbn
9780585395098
Other physical details
ill.
Specific material designation
remote
Label
Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado, (electronic book)
Publication
Bibliography note
Includes bibliographical references and index
Color
multicolored
Contents
pt. 1. Strategies -- Chemical construction of immunotoxins -- Construction of ribonuclease-antibody conjugates for selective cytotoxicity -- Intracellular targeting using bispecific antibodies -- Antibody conjugation methods for active targeting of liposomes -- Folate as a targeting device for proteins utilizing folate receptor-mediated endocytosis -- Preparation of recombinant RNase single-chain antibody fusion proteins -- pt. 2. Theoretical aspects -- Practical considerations in the exploitation of passive tumor targeting -- Effect of dose, molecular size, and binding affinity on uptake of antibodies -- Inhibition of tumor blood flow -- pt. 3. Applications -- Targeting in myocardial infarction -- Targeting HIV-infected cells -- Making fusion toxins to targetleukemia and lymphoma -- Antibody-bearing liposomes as chloroquine vehicles in treatment of murine malaria -- Immunotargeting of catalase to the pulmonary vascular endothelium -- Targeted gene transfer: a practical guide based on experience with lipid-based plasmid delivery systems
Control code
SPR49851566
Dimensions
unknown
Extent
1 online resource (x, 318 p.)
Form of item
online
Isbn
9780585395098
Other physical details
ill.
Specific material designation
remote

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