Coverart for item
The Resource Epithelial polarity, Gerard Apodaca and Luciana I. Gallo, (electronic book)

Epithelial polarity, Gerard Apodaca and Luciana I. Gallo, (electronic book)

Label
Epithelial polarity
Title
Epithelial polarity
Statement of responsibility
Gerard Apodaca and Luciana I. Gallo
Creator
Contributor
Subject
Language
eng
Summary
Epithelial cells exhibit an apical-basolateral axis of polarity that is generated during embryogenesis, is maintained throughout adult life in the face of constant cell regeneration, and is perturbed in several epithelial-associated diseases. We examine the structural and functional organization of epithelial tissues, as well as the events critical for generating epithelial asymmetry including vectorial trafficking of proteins and lipids, association of signaling and polarity proteins with subdomains of the plasma membrane, and 3D orientation of epithelial cells in response to cell-cell and cell-matrix interactions. As a paradigm to understand how these three processes are coordinated in time and space, we explore apical lumen formation. We also examine the final steps in epithelial morphogenesis, including brush border morphogenesis and ciliogenesis. Finally, we provide examples of disease processes that result from defects in epithelial polarity including diabetes insipidus, microvillar inclusion disease, hereditary deafness, ciliopathies, and cancer
Member of
Cataloging source
CaBNVSL
http://library.link/vocab/creatorName
Apodaca, Gerard.
Dewey number
611.0187
Illustrations
illustrations
Index
no index present
LC call number
QP88.4
LC item number
.A653 2013
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Gallo, Luciana I.
http://library.link/vocab/subjectName
  • Epithelial cells
  • Epithelial Cells
  • Cell Polarity
Target audience
  • adult
  • specialized
Label
Epithelial polarity, Gerard Apodaca and Luciana I. Gallo, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 77-114)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • 1. Introduction --
  • 2. Epithelial cell organization and asymmetry -- 2.1 Organization and structure of epithelial cells -- 2.2 Plasma membrane asymmetry -- 2.2.1 Apical membrane domain -- 2.2.2 Lateral membrane domain -- 2.2.3 The basal membrane -- 2.3 Membrane organelle and cytoskeletal asymmetry --
  • 3. Generation and maintenance of epithelial polarity -- 3.1 Model systems to study epithelial polarity -- 3.2 Vectorial trafficking pathways in polarized epithelial cells -- 3.2.1 Biosynthetic pathways -- 3.2.2 Endocytic pathways -- 3.3 The machinery for vectorial sorting and transport of proteins -- 3.3.1 Sorting of basolateral membrane proteins -- 3.3.2 Sorting of apical membrane proteins -- 3.3.3 Transport mechanisms and membrane fusion -- 3.4 Role of polarity complexes and signaling machinery in epithelial polarization -- 3.5 Function of cell-cell and cell-matrix interactions in epithelial polarization -- 3.6 Biogenesis of luminal and basolateral membrane domains -- 3.6.1 Lumen formation -- 3.6.2 Formation of the basolateral domain -- 3.7 Completion of epithelial morphogenesis -- 3.7.1 Brush border morphogenesis -- 3.7.2 Ciliogenesis and membrane traffic -- 3.8 Generation of cellular asymmetry during development --
  • 4. Diseases that result from defects in epithelial polarity -- 4.1 Mutations that affect sorting and trafficking of membrane proteins -- 4.2 Mutations in the polarized sorting/trafficking machinery -- 4.3 Defects in junction-associated proteins -- 4.4 Ciliopathies -- 4.5 Cancer and epithelial polarity --
  • Acknowledgments -- References -- Author biographies
Control code
201303BBC002
Dimensions
unknown
Extent
1 electronic text (viii, 115 p.)
File format
multiple file formats
Form of item
online
Isbn
9781615043996
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.4199/C00077ED1V01Y201303BBC002
Other physical details
ill., digital file.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
Epithelial polarity, Gerard Apodaca and Luciana I. Gallo, (electronic book)
Publication
Bibliography note
Includes bibliographical references (p. 77-114)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • 1. Introduction --
  • 2. Epithelial cell organization and asymmetry -- 2.1 Organization and structure of epithelial cells -- 2.2 Plasma membrane asymmetry -- 2.2.1 Apical membrane domain -- 2.2.2 Lateral membrane domain -- 2.2.3 The basal membrane -- 2.3 Membrane organelle and cytoskeletal asymmetry --
  • 3. Generation and maintenance of epithelial polarity -- 3.1 Model systems to study epithelial polarity -- 3.2 Vectorial trafficking pathways in polarized epithelial cells -- 3.2.1 Biosynthetic pathways -- 3.2.2 Endocytic pathways -- 3.3 The machinery for vectorial sorting and transport of proteins -- 3.3.1 Sorting of basolateral membrane proteins -- 3.3.2 Sorting of apical membrane proteins -- 3.3.3 Transport mechanisms and membrane fusion -- 3.4 Role of polarity complexes and signaling machinery in epithelial polarization -- 3.5 Function of cell-cell and cell-matrix interactions in epithelial polarization -- 3.6 Biogenesis of luminal and basolateral membrane domains -- 3.6.1 Lumen formation -- 3.6.2 Formation of the basolateral domain -- 3.7 Completion of epithelial morphogenesis -- 3.7.1 Brush border morphogenesis -- 3.7.2 Ciliogenesis and membrane traffic -- 3.8 Generation of cellular asymmetry during development --
  • 4. Diseases that result from defects in epithelial polarity -- 4.1 Mutations that affect sorting and trafficking of membrane proteins -- 4.2 Mutations in the polarized sorting/trafficking machinery -- 4.3 Defects in junction-associated proteins -- 4.4 Ciliopathies -- 4.5 Cancer and epithelial polarity --
  • Acknowledgments -- References -- Author biographies
Control code
201303BBC002
Dimensions
unknown
Extent
1 electronic text (viii, 115 p.)
File format
multiple file formats
Form of item
online
Isbn
9781615043996
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.4199/C00077ED1V01Y201303BBC002
Other physical details
ill., digital file.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

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