Coverart for item
The Resource FGF signalling in vertebrate development, Mary Elizabeth Pownall and Harry V. Isaacs, (electronic book)

FGF signalling in vertebrate development, Mary Elizabeth Pownall and Harry V. Isaacs, (electronic book)

Label
FGF signalling in vertebrate development
Title
FGF signalling in vertebrate development
Statement of responsibility
Mary Elizabeth Pownall and Harry V. Isaacs
Title variation
Fibroblast growth factors signalling in vertebrate development
Creator
Contributor
Subject
Language
eng
Summary
The fibroblast growth factors (FGFs) represent one of the relatively few families of extracellular signalling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that misregulation of this signalling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development. This review will explore examples from several vertebrate model organisms and include discussions of the role of FGF signalling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development, and the establishment of right-left asymmetry
Member of
Cataloging source
CaBNvSL
http://library.link/vocab/creatorName
Pownall, Mary Elizabeth.
Dewey number
612.01575
Illustrations
illustrations
Index
no index present
LC call number
QP552.F5
LC item number
P684 2010
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Isaacs, Harry V.
Series statement
Colloquium series on developmental biology
Series volume
2
http://library.link/vocab/subjectName
  • Fibroblast growth factors
  • Vertebrates
  • Fibroblast Growth Factors
  • Vertebrates
Target audience
specialized
Label
FGF signalling in vertebrate development, Mary Elizabeth Pownall and Harry V. Isaacs, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 55-74a)
Color
multicolored
Contents
Introduction -- FGF ligands -- FGF receptors -- Heparan Sulphate Proteoglycans -- FGF signal transduction -- Regulators -- Sulfatases and Sulfotransferases -- Sprouty -- MAPK phosphatases -- Sef -- FLRT -- Integration with other signalling pathways -- Mesoderm induction -- Neural induction -- FGF signalling and posterior neural patterning -- FGF signalling at the Isthmic Organizer -- FGF signalling at the anterior neural ridge -- Morphogenesis -- Gastrulation -- Inner ear -- Lateral line -- Pronephros -- Branching morphogenesis -- The developing heart -- Somitogenesis -- FGF and myogenesis -- Limb development -- Apical ectodermal ridge -- The ZPA requires the AER and vice versa -- FGF and left-right asymmetry -- Perspectives -- References -- About the authors
Dimensions
unknown
Extent
1 electronic text (viii, 75 p. : ill.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615040643
Other physical details
digital file
Reformatting quality
access
Specific material designation
remote
Label
FGF signalling in vertebrate development, Mary Elizabeth Pownall and Harry V. Isaacs, (electronic book)
Publication
Bibliography note
Includes bibliographical references (p. 55-74a)
Color
multicolored
Contents
Introduction -- FGF ligands -- FGF receptors -- Heparan Sulphate Proteoglycans -- FGF signal transduction -- Regulators -- Sulfatases and Sulfotransferases -- Sprouty -- MAPK phosphatases -- Sef -- FLRT -- Integration with other signalling pathways -- Mesoderm induction -- Neural induction -- FGF signalling and posterior neural patterning -- FGF signalling at the Isthmic Organizer -- FGF signalling at the anterior neural ridge -- Morphogenesis -- Gastrulation -- Inner ear -- Lateral line -- Pronephros -- Branching morphogenesis -- The developing heart -- Somitogenesis -- FGF and myogenesis -- Limb development -- Apical ectodermal ridge -- The ZPA requires the AER and vice versa -- FGF and left-right asymmetry -- Perspectives -- References -- About the authors
Dimensions
unknown
Extent
1 electronic text (viii, 75 p. : ill.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615040643
Other physical details
digital file
Reformatting quality
access
Specific material designation
remote

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