Coverart for item
The Resource Heme oxygenase and the kidney, David E. Stec, (electronic book)

Heme oxygenase and the kidney, David E. Stec, (electronic book)

Label
Heme oxygenase and the kidney
Title
Heme oxygenase and the kidney
Statement of responsibility
David E. Stec
Creator
Subject
Language
eng
Summary
Heme oxygenases (HOs) are the enzymes responsible for the breakdown of heme and the generation of biliverdin/bilirubin and carbon monoxide (CO). The kidney is a complex organ consisting of many different cell types all working together for the single purpose of filtering the blood to eliminate waste products and conserving ions, minerals, and water necessary for life. HO enzymes and their products play a critical role in the normal function of the kidney as well as protecting the kidney from various insults including ischemia and exposure to nephrotoxins. For example, the HO metabolite, bilirubin, is a potent antioxidant which can limit damage to renal tubular epithelial cells following exposure to nephrotoxins associated with chemotherapy or traumatic injury. Another HO metabolite, CO, is an important vasodilator of renal blood vessels and helps protect against severe decreases in renal blood flow in conditions as diverse as exposure to radiocontrast agents and in hypertension-induced kidney disease. HO and its metabolites also play an important role in the survival of kidney cells after acute and chronic injuries by regulating important cell growth and programmed cell death pathways. The intent of this volume is to highlight the important role that HO enzymes and their related metabolites, bilirubin and CO, play in the regulation of renal function and in the response of the kidney to both acute and chronic pathologies
Member of
Cataloging source
CaBNVSL
http://library.link/vocab/creatorName
Stec, David E
Dewey number
612.1111
Illustrations
illustrations
Index
no index present
LC call number
QP603.H45
LC item number
S745 2011
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
Series statement
Colloquium series on integrated systems physiology, from molecule to function
Series volume
24
http://library.link/vocab/subjectName
  • Heme oxygenase
  • Kidneys
Target audience
specialized
Label
Heme oxygenase and the kidney, David E. Stec, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 51-69)
Color
multicolored
Contents
  • 1. Introduction to the HO system -- 1.1 Historical background of discovery -- 1.2 Description of reaction and products -- 1.3 Isoforms and distribution in the kidney --
  • 2. HO and renal vascular function -- 2.1 Expression of HO isoforms in the renal vasculature -- 2.2 Effects of HO and its metabolites on renal vascular tone -- 2.3 HO and renal autoregulation --
  • 3. HO and renal tubule function -- 3.1 HO and proximal tubule function -- 3.2 HO and thick ascending loop of henle function -- 3.3 HO and distal tubule function --
  • 4. HO and acute kidney injury -- 4.1 Ischemia-reperfusion injury -- 4.2 Nephrotoxin-induced acute kidney injury -- 4.3 Radiocontrast-induced acute kidney injury -- 4.4 Nephritis --
  • 5. HO and chronic kidney injury -- 5.1 Hypertension-induced kidney injury -- 5.2 Diabetic nephropathy -- 5.3 Renal transplantation -- 5.4 Renal cancers --
  • 6. Future of renal HO research -- 6.1 Animal models -- 6.2 Viruses and SiRNA -- 6.3 New HO pharmacological reagents -- 6.4 Summary -- References -- Author biography
Control code
201107ISP024
Dimensions
unknown
Extent
1 electronic text (viii, 71 p.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615042135
Other physical details
ill., digital file
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
Heme oxygenase and the kidney, David E. Stec, (electronic book)
Publication
Bibliography note
Includes bibliographical references (p. 51-69)
Color
multicolored
Contents
  • 1. Introduction to the HO system -- 1.1 Historical background of discovery -- 1.2 Description of reaction and products -- 1.3 Isoforms and distribution in the kidney --
  • 2. HO and renal vascular function -- 2.1 Expression of HO isoforms in the renal vasculature -- 2.2 Effects of HO and its metabolites on renal vascular tone -- 2.3 HO and renal autoregulation --
  • 3. HO and renal tubule function -- 3.1 HO and proximal tubule function -- 3.2 HO and thick ascending loop of henle function -- 3.3 HO and distal tubule function --
  • 4. HO and acute kidney injury -- 4.1 Ischemia-reperfusion injury -- 4.2 Nephrotoxin-induced acute kidney injury -- 4.3 Radiocontrast-induced acute kidney injury -- 4.4 Nephritis --
  • 5. HO and chronic kidney injury -- 5.1 Hypertension-induced kidney injury -- 5.2 Diabetic nephropathy -- 5.3 Renal transplantation -- 5.4 Renal cancers --
  • 6. Future of renal HO research -- 6.1 Animal models -- 6.2 Viruses and SiRNA -- 6.3 New HO pharmacological reagents -- 6.4 Summary -- References -- Author biography
Control code
201107ISP024
Dimensions
unknown
Extent
1 electronic text (viii, 71 p.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615042135
Other physical details
ill., digital file
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

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