Coverart for item
The Resource Hepatic circulation : physiology and pathophysiology, W. Wayne Lautt, (electronic book)

Hepatic circulation : physiology and pathophysiology, W. Wayne Lautt, (electronic book)

Label
Hepatic circulation : physiology and pathophysiology
Title
Hepatic circulation
Title remainder
physiology and pathophysiology
Statement of responsibility
W. Wayne Lautt
Creator
Subject
Language
eng
Summary
The Hepatic circulation is unique among vascular beds. The most obvious unique features include the dual vascular supply; the mechanism of intrinsic regulation of the hepatic artery (the hepatic arterial buffer response); the fact that portal blood flow, supplying two thirds of liver blood flow, is not controlled directly by the liver; the fact that 20% of the cardiac output rushes through the most vascularized organ in the body, driven by a pressure gradient of only a few millimeters of mercury; the extremely distensible capacitance and venous resistance sites; the unidirectional acinar blood flow that regulates parenchymal cell metabolic specialization; and the high concentration of macrophagic (Kupffer) cells filtering the blood. The liver is the only organ reported to have regional blood flow monitored by the autonomic nervous system. This mechanism, when dysfunctional, accounts for the hepatorenal syndrome and offers a mechanistic therapeutic target to treat this syndrome. The trigger for liver regeneration is dependent on hepatic hemodynamics so that chronic liver blood flow regulates liver cell mass. In severe liver disease, the whole body circulation is reorganized, by forming portacaval shunts, to accommodate the increased intrahepatic venous resistance. These shunts protect the venous drainage of the splanchnic organs but lead to loss of major regulatory roles of the liver. The development of knowledge of the hepatic vasculature is presented from a historical perspective with modern concepts summarized based on the perspective of the author's four decades of devotion to this most marvelous of organs
Member of
Cataloging source
CaBNvSL
http://library.link/vocab/creatorName
Lautt, W. Wayne
Dewey number
611.36
Illustrations
illustrations
Index
no index present
LC call number
QM351
LC item number
.L284 2010
Literary form
non fiction
Nature of contents
dictionaries
Series statement
Colloquium series on integrated systems physiology, from molecule to function
Series volume
1
http://library.link/vocab/subjectName
  • Liver
  • Hepatic artery
  • Liver Circulation
Target audience
adult
Label
Hepatic circulation : physiology and pathophysiology, W. Wayne Lautt, (electronic book)
Instantiates
Publication
Note
Part of: 'Colloquium digital library of life sciences'
Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references (p. 149-174a)
Color
multicolored
Contents
  • 1. Historical perspectives --
  • 2. Overview -- Microcirculation -- Hepatic microvascular zones -- Intrahepatic flow distribution -- Kupffer cells -- Stellate cells -- Sinusoidal endothelial cells -- The space of mall --
  • 3. Fluid exchange -- Flow-limited distribution of blood-borne substances -- Ascites formation -- Effects of drugs on fluid exchange -- Effects of hepatic nerve stimulation -- Blood flow and hepatic clearance of drugs and hormones --
  • 4. Capacitance -- Hepatic blood volume -- Capacitance functions in diseased livers --
  • 5. Resistance in the hepatic artery -- Intrinsic blood flow regulation: the hepatic arterial buffer response and autoregulation -- Metabolism and hepatic blood flow -- Portal flow regulation of hepatic arterial flow -- Autoregulation -- Quantitative aspects of the HABR -- Roles of the HABR -- Clinical relevance -- Unresolved issues -- Extrinsic influences -- Caffeine -- Vasodilators -- Carbon monoxide -- Hydrogen sulfide --
  • 6. Resistance in the venous system -- Essential assumptions -- Passive distensibility --
  • 7. Fetal and neonatal hepatic circulation --
  • 8. In vivo pharmacodynamic approaches -- Resistance or conductance -- Index of contractility -- Surgical preparation considerations -- Effect of vasoactive drugs on the hepatic artery when administered intravenously --
  • 9. Nitric oxide -- Shear stress --
  • 10. Adenosine --
  • 11. Hepatic nerves -- Extrinsic nerve supply -- Intrinsic nerves -- Developmental aspects -- Vascular responses -- The hepatic artery -- Basal tone -- Reflex activation -- Neurovascular approach in vivo -- Blood flow distribution -- Venous resistance vessel responses to sympathetic nerve stimulation -- Presinusoidal or portal responses -- Hepatic venous resistance responses -- Hepatic blood volume -- Stressed and unstressed volume -- Responses to direct nerve stimulation -- Reflex control of hepatic capacitance -- Hepatic fluid exchange -- Noradrenaline overflow -- Neurotransmitters and neuromodulation -- Disease states -- Technical considerations (avoid the sucker punch) --
  • 12. Hepatic circulation and toxicology -- Hepatic blood flow -- Veno-occlusive toxins -- Heterogeneity of perfusion -- Capillarization -- Ethanol -- Methodological considerations -- Free radicals and antioxidants -- Samec --
  • 13. Hepatorenal syndrome --
  • 14. Integrative hepatic response to hemorrhage --
  • 15. Blood flow regulation of hepatocyte proliferation --
  • 16. Multiple mechanisms maintaining a constant hepatic blood flow to liver mass ratio -- Overview -- Hepatic compliance -- The HABR -- The hepatorenal reflex -- Modulation of vasoconstrictors by adenosine and nitric oxide -- Blood flow regulation of hepatocyte proliferation --
  • 17. Pathopharmacology and repurposing drugs as a research strategy -- The pathology, the hepatorenal syndrome -- References
Dimensions
unknown
Extent
1 electronic text (xiii, 174a p. : ill.)
File format
multiple file formats
Isbn
9781615040094
Level of compression
unknown
Other physical details
digital file. ;
Quality assurance targets
unknown
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
Hepatic circulation : physiology and pathophysiology, W. Wayne Lautt, (electronic book)
Publication
Note
Part of: 'Colloquium digital library of life sciences'
Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references (p. 149-174a)
Color
multicolored
Contents
  • 1. Historical perspectives --
  • 2. Overview -- Microcirculation -- Hepatic microvascular zones -- Intrahepatic flow distribution -- Kupffer cells -- Stellate cells -- Sinusoidal endothelial cells -- The space of mall --
  • 3. Fluid exchange -- Flow-limited distribution of blood-borne substances -- Ascites formation -- Effects of drugs on fluid exchange -- Effects of hepatic nerve stimulation -- Blood flow and hepatic clearance of drugs and hormones --
  • 4. Capacitance -- Hepatic blood volume -- Capacitance functions in diseased livers --
  • 5. Resistance in the hepatic artery -- Intrinsic blood flow regulation: the hepatic arterial buffer response and autoregulation -- Metabolism and hepatic blood flow -- Portal flow regulation of hepatic arterial flow -- Autoregulation -- Quantitative aspects of the HABR -- Roles of the HABR -- Clinical relevance -- Unresolved issues -- Extrinsic influences -- Caffeine -- Vasodilators -- Carbon monoxide -- Hydrogen sulfide --
  • 6. Resistance in the venous system -- Essential assumptions -- Passive distensibility --
  • 7. Fetal and neonatal hepatic circulation --
  • 8. In vivo pharmacodynamic approaches -- Resistance or conductance -- Index of contractility -- Surgical preparation considerations -- Effect of vasoactive drugs on the hepatic artery when administered intravenously --
  • 9. Nitric oxide -- Shear stress --
  • 10. Adenosine --
  • 11. Hepatic nerves -- Extrinsic nerve supply -- Intrinsic nerves -- Developmental aspects -- Vascular responses -- The hepatic artery -- Basal tone -- Reflex activation -- Neurovascular approach in vivo -- Blood flow distribution -- Venous resistance vessel responses to sympathetic nerve stimulation -- Presinusoidal or portal responses -- Hepatic venous resistance responses -- Hepatic blood volume -- Stressed and unstressed volume -- Responses to direct nerve stimulation -- Reflex control of hepatic capacitance -- Hepatic fluid exchange -- Noradrenaline overflow -- Neurotransmitters and neuromodulation -- Disease states -- Technical considerations (avoid the sucker punch) --
  • 12. Hepatic circulation and toxicology -- Hepatic blood flow -- Veno-occlusive toxins -- Heterogeneity of perfusion -- Capillarization -- Ethanol -- Methodological considerations -- Free radicals and antioxidants -- Samec --
  • 13. Hepatorenal syndrome --
  • 14. Integrative hepatic response to hemorrhage --
  • 15. Blood flow regulation of hepatocyte proliferation --
  • 16. Multiple mechanisms maintaining a constant hepatic blood flow to liver mass ratio -- Overview -- Hepatic compliance -- The HABR -- The hepatorenal reflex -- Modulation of vasoconstrictors by adenosine and nitric oxide -- Blood flow regulation of hepatocyte proliferation --
  • 17. Pathopharmacology and repurposing drugs as a research strategy -- The pathology, the hepatorenal syndrome -- References
Dimensions
unknown
Extent
1 electronic text (xiii, 174a p. : ill.)
File format
multiple file formats
Isbn
9781615040094
Level of compression
unknown
Other physical details
digital file. ;
Quality assurance targets
unknown
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

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