Coverart for item
The Resource Identification and quantification of drugs, metabolites and metabolizing enzymes by LC-MS, edited by Swapan K. Chowdhury, (electronic book)

Identification and quantification of drugs, metabolites and metabolizing enzymes by LC-MS, edited by Swapan K. Chowdhury, (electronic book)

Label
Identification and quantification of drugs, metabolites and metabolizing enzymes by LC-MS
Title
Identification and quantification of drugs, metabolites and metabolizing enzymes by LC-MS
Statement of responsibility
edited by Swapan K. Chowdhury
Contributor
Subject
Language
eng
Summary
As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners. * Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies * Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them * Highlights problems associated with drug quantification and offers practical solutions
Member of
Cataloging source
OPELS
Dewey number
615/.7
Illustrations
illustrations
Index
index present
LC call number
RM301.55
LC item number
.I34 2005eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Chowdhury, Swapan K
Series statement
Progress in pharmaceutical and biomedical analysis
Series volume
6
http://library.link/vocab/subjectName
  • Drugs
  • Enzymes
  • Pharmaceutical Preparations
  • Pharmaceutical Preparations
  • Chromatography, Liquid
  • Spectrum Analysis, Mass
  • Drug Design
Label
Identification and quantification of drugs, metabolites and metabolizing enzymes by LC-MS, edited by Swapan K. Chowdhury, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction: LC-MS and Drug Metabolism: A Journey Back in Time, Present Trends and Future Direction. -- Strategies for Increasing Throughput for PK Samples in a Drug Discovery Environment. -- Commonly Encountered Analytical Problems and their Solutions in Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) Methods Uded in Drug Development. -- Pitfalls in Quantitative LC-MS/MS: Metabolites Contributing to Measured Drug Concentrations. -- In <IT>vitro</IT> DMPK Sreening in Drug Discovery, Role of LC-MS/MS. -- Metabolite Identification by LC-MS: Applications in Drug Discovery and Development. -- Screening for the Assessment of Electrophilic Metabolite Formation Early in Drug Discovery Using HPLC-MS. -- Liquid chromatography Tandem Mass Spectrometry-Based Metabolite Identification Strategies in Pharmaceutical Research. -- Quantification and Structural Elucidation of Low Quantities of Radiolabeled Metabolites Using Microplate Scintillation Counting (MSC) Techniques in Conjunction with LC-MS. -- -- Oxidative Metabolites of Drugs and Xenobiotics: LC-MS Methods to Identify and Characterize in Biological Matrices. -- Detection and Charactrization of Highly Polar Metabolites by LC-MS: Proper Selection of LC Column and Use of Stable Isotope Labeled Drug to Study Metabolism of Rabavirin in Rats. -- Cytochrome P450 (CYP) and UDP-Glucuronosyltransferase (UGT) Enzymes: Role in Drug Metabolism, Polymorphism, and Identification of their Involvement in Drug Metabolism
Control code
SCIDI162130070
Dimensions
unknown
Edition
1st ed.
Extent
1 online resource (xvi, 338 p.)
Form of item
online
Isbn
9780080456065
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
ill.
Specific material designation
remote
Label
Identification and quantification of drugs, metabolites and metabolizing enzymes by LC-MS, edited by Swapan K. Chowdhury, (electronic book)
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction: LC-MS and Drug Metabolism: A Journey Back in Time, Present Trends and Future Direction. -- Strategies for Increasing Throughput for PK Samples in a Drug Discovery Environment. -- Commonly Encountered Analytical Problems and their Solutions in Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) Methods Uded in Drug Development. -- Pitfalls in Quantitative LC-MS/MS: Metabolites Contributing to Measured Drug Concentrations. -- In <IT>vitro</IT> DMPK Sreening in Drug Discovery, Role of LC-MS/MS. -- Metabolite Identification by LC-MS: Applications in Drug Discovery and Development. -- Screening for the Assessment of Electrophilic Metabolite Formation Early in Drug Discovery Using HPLC-MS. -- Liquid chromatography Tandem Mass Spectrometry-Based Metabolite Identification Strategies in Pharmaceutical Research. -- Quantification and Structural Elucidation of Low Quantities of Radiolabeled Metabolites Using Microplate Scintillation Counting (MSC) Techniques in Conjunction with LC-MS. -- -- Oxidative Metabolites of Drugs and Xenobiotics: LC-MS Methods to Identify and Characterize in Biological Matrices. -- Detection and Charactrization of Highly Polar Metabolites by LC-MS: Proper Selection of LC Column and Use of Stable Isotope Labeled Drug to Study Metabolism of Rabavirin in Rats. -- Cytochrome P450 (CYP) and UDP-Glucuronosyltransferase (UGT) Enzymes: Role in Drug Metabolism, Polymorphism, and Identification of their Involvement in Drug Metabolism
Control code
SCIDI162130070
Dimensions
unknown
Edition
1st ed.
Extent
1 online resource (xvi, 338 p.)
Form of item
online
Isbn
9780080456065
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
ill.
Specific material designation
remote

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