Coverart for item
The Resource Improving the therapeutic ratio in head and neck cancer, volume editor, Randall J. Kimple

Improving the therapeutic ratio in head and neck cancer, volume editor, Randall J. Kimple

Label
Improving the therapeutic ratio in head and neck cancer
Title
Improving the therapeutic ratio in head and neck cancer
Statement of responsibility
volume editor, Randall J. Kimple
Contributor
Subject
Genre
Language
eng
Summary
Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites
Member of
Cataloging source
EBLCP
Dewey number
  • 616.9940654
  • 616.99491
Index
index present
LC call number
  • RC271.D52
  • RC280.H4
LC item number
R65 2020
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Kimple, Randall J
Series statement
Cancer sensitizing agents for chemotherapy
Series volume
6
http://library.link/vocab/subjectName
  • Cancer
  • Head
  • Neck
  • Head and Neck Neoplasms
  • Head and Neck Neoplasms
  • Cancer
  • Head
  • Neck
Label
Improving the therapeutic ratio in head and neck cancer, volume editor, Randall J. Kimple
Instantiates
Publication
Note
Restoration of wild-type p53 confirmation and function in HNSCC as a novel therapeutic approach
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Front Cover; Improving the Therapeutic Ratio in Head and Neck Cancer; Copyright; Aims and Scope for Series ""Cancer Sensitizing Agents for Chemotherapy; About the Series Editor; About the Editor; Aims and Scope for ""Improving the Therapeutic Ratio in Head and Neck Cancer; Preface; Contents; Contributors; Chapter 1: Overview of head and neck cancer management; Introduction; Anatomy; Clinical evaluation; Oropharynx; Epidemiology; Pathology; Anatomy and staging; General treatment approach; Initial surgery; Initial radiation-based therapy; Key clinical research themes; Nasopharynx; Epidemiology
  • PathologyAnatomy and staging; General treatment approach; Key clinical research themes; Oral cavity; Epidemiology and pathology; Anatomy and staging; General treatment approach; Key clinical research themes; Larynx and hypopharynx; Epidemiology and staging; General treatment approach; Key clinical research themes; Salivary gland tumors; Epidemiology and pathology; Anatomy and staging; General treatment approach and key clinical research themes; Recurrent and metastatic squamous cell carcinoma of the head and neck; Conclusion; References
  • Chapter 2: The role of molecularly targeted therapies and immunotherapy in head and neck cancerCurrent therapies for recurrent/metastatic disease; Early work with cytotoxic agents; Emergence of targeted therapy against the epidermal growth factor receptor (EGFR); Cetuximab plus chemotherapy in the first line metastatic setting; Panitumumab as an alternative targeted agent for HNSCC; Practical approach to first line systemic treatment; Dawn of an immunotherapy trend; Pembrolizumab; Nivolumab; Durvalumab; Ongoing trials and future directions; Future directions; Acknowledgments; References
  • Chapter 3: Combining radiation and chemotherapy to improve the therapeutic ratioBasic principles of radiobiology; Basic principles of radiation-induced cell death; Basic principles of radiotherapy in head and neck cancer management; Basic principles of toxicities of head and neck cancer management; Widening the therapeutic window; Radiotherapy dose/volume reduction in the absence of a surgical component or induction chemotherapy; Radiotherapy dose/volume reduction following induction chemotherapy; Systemic therapy toxicity studies without radiotherapy or surgical components
  • Radiotherapy dose/volume reductions with a surgical componentRadiotherapy protectors; Proton therapy; Conclusion; Acknowledgments; References; Chapter 4: Targeting TP53 to augment therapeutic response in head and neck cancer; Introduction; Current treatment for head and neck squamous cell carcinoma (HNSCC); Mutations in TP53 are common deleterious genetic alterations in HNSCC; Tumor suppressive functions of TP53; TP53 mutations as a prognostic and predictive biomarker for poor outcomes in HNSCC; TP53 gene transfer therapy for HNSCC
Dimensions
unknown
Edition
First edition.
Extent
1 online resource (378 pages)
File format
unknown
Form of item
online
Isbn
9780128178690
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
Online access with subscription: Elsevier (Sciencedirect Freedom Collection)
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • on1124608942
  • (OCoLC)1124608942
Label
Improving the therapeutic ratio in head and neck cancer, volume editor, Randall J. Kimple
Publication
Note
Restoration of wild-type p53 confirmation and function in HNSCC as a novel therapeutic approach
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Front Cover; Improving the Therapeutic Ratio in Head and Neck Cancer; Copyright; Aims and Scope for Series ""Cancer Sensitizing Agents for Chemotherapy; About the Series Editor; About the Editor; Aims and Scope for ""Improving the Therapeutic Ratio in Head and Neck Cancer; Preface; Contents; Contributors; Chapter 1: Overview of head and neck cancer management; Introduction; Anatomy; Clinical evaluation; Oropharynx; Epidemiology; Pathology; Anatomy and staging; General treatment approach; Initial surgery; Initial radiation-based therapy; Key clinical research themes; Nasopharynx; Epidemiology
  • PathologyAnatomy and staging; General treatment approach; Key clinical research themes; Oral cavity; Epidemiology and pathology; Anatomy and staging; General treatment approach; Key clinical research themes; Larynx and hypopharynx; Epidemiology and staging; General treatment approach; Key clinical research themes; Salivary gland tumors; Epidemiology and pathology; Anatomy and staging; General treatment approach and key clinical research themes; Recurrent and metastatic squamous cell carcinoma of the head and neck; Conclusion; References
  • Chapter 2: The role of molecularly targeted therapies and immunotherapy in head and neck cancerCurrent therapies for recurrent/metastatic disease; Early work with cytotoxic agents; Emergence of targeted therapy against the epidermal growth factor receptor (EGFR); Cetuximab plus chemotherapy in the first line metastatic setting; Panitumumab as an alternative targeted agent for HNSCC; Practical approach to first line systemic treatment; Dawn of an immunotherapy trend; Pembrolizumab; Nivolumab; Durvalumab; Ongoing trials and future directions; Future directions; Acknowledgments; References
  • Chapter 3: Combining radiation and chemotherapy to improve the therapeutic ratioBasic principles of radiobiology; Basic principles of radiation-induced cell death; Basic principles of radiotherapy in head and neck cancer management; Basic principles of toxicities of head and neck cancer management; Widening the therapeutic window; Radiotherapy dose/volume reduction in the absence of a surgical component or induction chemotherapy; Radiotherapy dose/volume reduction following induction chemotherapy; Systemic therapy toxicity studies without radiotherapy or surgical components
  • Radiotherapy dose/volume reductions with a surgical componentRadiotherapy protectors; Proton therapy; Conclusion; Acknowledgments; References; Chapter 4: Targeting TP53 to augment therapeutic response in head and neck cancer; Introduction; Current treatment for head and neck squamous cell carcinoma (HNSCC); Mutations in TP53 are common deleterious genetic alterations in HNSCC; Tumor suppressive functions of TP53; TP53 mutations as a prognostic and predictive biomarker for poor outcomes in HNSCC; TP53 gene transfer therapy for HNSCC
Dimensions
unknown
Edition
First edition.
Extent
1 online resource (378 pages)
File format
unknown
Form of item
online
Isbn
9780128178690
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
Online access with subscription: Elsevier (Sciencedirect Freedom Collection)
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • on1124608942
  • (OCoLC)1124608942

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