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The Resource Inflammation and the microcirculation, D. Neil Granger, Elena Senchenkova, (electronic book)

Inflammation and the microcirculation, D. Neil Granger, Elena Senchenkova, (electronic book)

Label
Inflammation and the microcirculation
Title
Inflammation and the microcirculation
Statement of responsibility
D. Neil Granger, Elena Senchenkova
Creator
Contributor
Subject
Language
eng
Summary
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation
Member of
Cataloging source
CaBNvSL
http://library.link/vocab/creatorName
Granger, D. Neil
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Senchenkova, Elena
Series statement
Integrated systems physiology, from molecule to function
Series volume
8
http://library.link/vocab/subjectName
  • Microcirculation disorders
  • Inflammation
Target audience
adult
Label
Inflammation and the microcirculation, D. Neil Granger, Elena Senchenkova, (electronic book)
Instantiates
Publication
Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references (p. 65-87)
Color
multicolored
Contents
  • 1. Introduction --
  • 2. Historical perspectives --
  • 3. Anatomical considerations -- Microvascular unit -- Arterioles -- Capillaries -- Venules -- Vessel wall components -- Endothelial cells -- Vascular smooth muscle -- Pericytes -- Perivascular auxiliary cells -- Mast cells -- Macrophages -- Fibroblasts --
  • 4. Impaired vasomotor responses -- Blood flow changes -- Endothelium-dependent vasodilation --
  • 5. Capillary perfusion --
  • 6. Angiogenesis -- Relevance to inflammation -- Mediators of the angiogenic response -- Vascular endothelial cell growth factor -- Cytokines and chemokines -- Reactive oxygen and nitrogen species -- Lymphangiogenesis --
  • 7. Leukocyte-endothelial cell adhesion -- Adhesion molecules -- Intraorgan heterogeneity of adhesion -- Selectins -- Endothelial cells immunoglobulin-like adhesion molecules -- Leukocyte integrins -- Chemical mediators -- Pro-adhesive mediators -- Anti-adhesive mediators -- Role of hydrodynamic forces -- Cytotoxicity of adherent leukocytes --
  • 8. Platelet-vessel wall interactions -- Platelet activation: mechanisms and consequences -- Platelet-endothelial adhesion -- Platelet-leukocyte adhesion -- Platelet-leukocyte aggregates --
  • 9. Coagulation and thrombosis -- Interdependence of coagulation and inflammation -- Inflammation-induced microvascular thrombosis: site-specific responses -- Chemical mediators of inflammation-enhanced thrombosis -- Reactive oxygen and nitrogen species --
  • 10. Endothelial barrier dysfunction -- Site of inflammation-induced barrier failure -- Role of circulating blood cells -- Leukocytes -- Platelets -- Role of perivascular cells -- Reactive oxygen and nitrogen species --
  • Epilogue -- References
Dimensions
unknown
Extent
1 electronic text (x, 87 p. : ill.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615041664
Level of compression
unknown
Other physical details
digital file. ;
Quality assurance targets
unknown
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
Inflammation and the microcirculation, D. Neil Granger, Elena Senchenkova, (electronic book)
Publication
Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references (p. 65-87)
Color
multicolored
Contents
  • 1. Introduction --
  • 2. Historical perspectives --
  • 3. Anatomical considerations -- Microvascular unit -- Arterioles -- Capillaries -- Venules -- Vessel wall components -- Endothelial cells -- Vascular smooth muscle -- Pericytes -- Perivascular auxiliary cells -- Mast cells -- Macrophages -- Fibroblasts --
  • 4. Impaired vasomotor responses -- Blood flow changes -- Endothelium-dependent vasodilation --
  • 5. Capillary perfusion --
  • 6. Angiogenesis -- Relevance to inflammation -- Mediators of the angiogenic response -- Vascular endothelial cell growth factor -- Cytokines and chemokines -- Reactive oxygen and nitrogen species -- Lymphangiogenesis --
  • 7. Leukocyte-endothelial cell adhesion -- Adhesion molecules -- Intraorgan heterogeneity of adhesion -- Selectins -- Endothelial cells immunoglobulin-like adhesion molecules -- Leukocyte integrins -- Chemical mediators -- Pro-adhesive mediators -- Anti-adhesive mediators -- Role of hydrodynamic forces -- Cytotoxicity of adherent leukocytes --
  • 8. Platelet-vessel wall interactions -- Platelet activation: mechanisms and consequences -- Platelet-endothelial adhesion -- Platelet-leukocyte adhesion -- Platelet-leukocyte aggregates --
  • 9. Coagulation and thrombosis -- Interdependence of coagulation and inflammation -- Inflammation-induced microvascular thrombosis: site-specific responses -- Chemical mediators of inflammation-enhanced thrombosis -- Reactive oxygen and nitrogen species --
  • 10. Endothelial barrier dysfunction -- Site of inflammation-induced barrier failure -- Role of circulating blood cells -- Leukocytes -- Platelets -- Role of perivascular cells -- Reactive oxygen and nitrogen species --
  • Epilogue -- References
Dimensions
unknown
Extent
1 electronic text (x, 87 p. : ill.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615041664
Level of compression
unknown
Other physical details
digital file. ;
Quality assurance targets
unknown
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

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