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The Resource Intestinal immune system, Soichiro Miura, Ryota Hokari, and Shunsuke Komoto, (electronic book)

Intestinal immune system, Soichiro Miura, Ryota Hokari, and Shunsuke Komoto, (electronic book)

Label
Intestinal immune system
Title
Intestinal immune system
Statement of responsibility
Soichiro Miura, Ryota Hokari, and Shunsuke Komoto
Creator
Contributor
Subject
Language
eng
Summary
In the intestine, a unique immunological system that is different from the systemic immune system exists to provide adaptive immunity in response to luminal bacteria and dietary antigens. There are many lymphoid cell aggregates called gut-associated lymphoid tissue (GALT) including Peyer's patches (PPs), which function as important induction sites for the mucosal immune response. M-cells are present in the epithelium of PPs, having a specialized structure for uptake of macromolecules such as bacteria. In addition to GALT, there are abundant lymphoid cells in the intestinal lamina propria, where they mainly play a role as immune effector cells. A strong innate immune system that mainly consists of dendritic cells, macrophages, and y8T lymphocytes also exists in the intestinal mucosa to assist the barrier function of intestinal epithelial cells
Member of
Cataloging source
CaBNVSL
http://library.link/vocab/creatorName
Miura, Soichiro
Dewey number
616.33079
Illustrations
illustrations
Index
no index present
LC call number
QR185.9.G37
LC item number
M585 2011
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Hokari, Ryota
  • Komoto, Shunsuke
Series statement
Colloquium series on integrated systems physiology, from molecule to function
Series volume
25
http://library.link/vocab/subjectName
Gastrointestinal system
Target audience
specialized
Label
Intestinal immune system, Soichiro Miura, Ryota Hokari, and Shunsuke Komoto, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 95-112)
Color
multicolored
Contents
  • 1. Introduction --
  • 2. GALT: its structure and formation -- 2.1. Peyer's patches (PPs) -- 2.1.1 Structure and function -- 2.1.2 Formation of PPs -- 2.2 M-cells -- 2.3 Crypt patch -- 2.4 Solitary or isolated lymphoid follicles (SLFs or ILFs) -- 2.5 Colonic patches --
  • 3. Intestinal epithelial cells and their immune function -- 3.1 Mucosal surface and mucous barrier -- 3.2 Tight junction and adherent junction -- 3.3 Paneth cells and antimicrobial peptides (host defense peptides) -- 3.4 Other defensive factors related to the surface barrier -- 3.5 Antigen presentation by intestinal epithelial cells --
  • 4. Innate immunity in the intestinal mucosa -- 4.1 Pattern recognition through TLRs (toll-like receptors) -- 4.2 Pattern recognition through NOD (NLR) and RIG -- 4.3 Mast cells, eosinophils, and basophils -- 4.4 NKT cells and NK cells -- 4.5 Intestinal macrophages --
  • 5. Intraepithelial lymphocytes (IELs) --
  • 6. Lymphoid cell trafficking in intestinal immunology -- 6.1 Lymphocyte migration into intestinal mucosa -- 6.2 Role of retinoic acid in lymphocyte migration -- 6.3 Regulation of lymphocyte emigration from secondary lymphoid tissues and the role of S1P --
  • 7. Site of induction of mucosal immunity and antigen presentation by dendritic cells -- 7.1 DCs in intestinal secondary lymphoid tissues -- 7.2 DCs in intestinal lamina propria -- 7.3 Plasmacytoid DCs (PDCs) in the intestine --
  • 8. Production of secretory IGA (SIGA) --
  • 9. Effector site of acquired immunity and T helper cell subpopulation -- 9.1 TH1 cells -- 9.2 TH2 cells -- 9.3 TH17 cells -- 9.4 TFH cells --
  • 10. Immune regulatory system and oral tolerance -- 10.1 Regulatory T cells (Tregs) -- 10.2 Oral tolerance and induction of tolerance by Tregs --
  • 11. Food allergy and celiac disease -- 11.1 Food allergy (food intolerance) -- 11.2 Allergic eosinophilic gastroenteritis (AEG) -- 11.3 Celiac disease (gluten-induced enteropathy) -- 11.3.1 Etiology -- 11.3.2 Clinical presentation and diagnosis -- 11.3.3 Treatment --
  • 12. Inflammatory bowel diseases -- 12.1 Clinical features of UC and CD -- 12.2 Immunological abnormalities in UC and CD -- 12.2.1 Changes in intestinal bacterial flora -- 12.2.2 Are there any specific immunological disorders for CD vs. UC? -- 12.2.3 Leukocyte recruitment and adhesion molecules in IBD -- 12.2.4 Genetic susceptibility and decreased mucosal regulation -- 12.3 Treatment of UC and CD from the standpoint of immunological disturbances --
  • 13. Enteric infection with pathogenic microbes and mucosal immunity -- 13.1 Mucosal immune response by pathogenic bacteria and vaccines -- 13.2 Symbiotic relationship with intestinal flora and its usefulness for immune defense against pathogenic microbes --
  • References
Control code
201107ISP025
Dimensions
unknown
Extent
1 electronic text (ix, 112 p.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615041442
Other physical details
ill., digital file
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
Intestinal immune system, Soichiro Miura, Ryota Hokari, and Shunsuke Komoto, (electronic book)
Publication
Bibliography note
Includes bibliographical references (p. 95-112)
Color
multicolored
Contents
  • 1. Introduction --
  • 2. GALT: its structure and formation -- 2.1. Peyer's patches (PPs) -- 2.1.1 Structure and function -- 2.1.2 Formation of PPs -- 2.2 M-cells -- 2.3 Crypt patch -- 2.4 Solitary or isolated lymphoid follicles (SLFs or ILFs) -- 2.5 Colonic patches --
  • 3. Intestinal epithelial cells and their immune function -- 3.1 Mucosal surface and mucous barrier -- 3.2 Tight junction and adherent junction -- 3.3 Paneth cells and antimicrobial peptides (host defense peptides) -- 3.4 Other defensive factors related to the surface barrier -- 3.5 Antigen presentation by intestinal epithelial cells --
  • 4. Innate immunity in the intestinal mucosa -- 4.1 Pattern recognition through TLRs (toll-like receptors) -- 4.2 Pattern recognition through NOD (NLR) and RIG -- 4.3 Mast cells, eosinophils, and basophils -- 4.4 NKT cells and NK cells -- 4.5 Intestinal macrophages --
  • 5. Intraepithelial lymphocytes (IELs) --
  • 6. Lymphoid cell trafficking in intestinal immunology -- 6.1 Lymphocyte migration into intestinal mucosa -- 6.2 Role of retinoic acid in lymphocyte migration -- 6.3 Regulation of lymphocyte emigration from secondary lymphoid tissues and the role of S1P --
  • 7. Site of induction of mucosal immunity and antigen presentation by dendritic cells -- 7.1 DCs in intestinal secondary lymphoid tissues -- 7.2 DCs in intestinal lamina propria -- 7.3 Plasmacytoid DCs (PDCs) in the intestine --
  • 8. Production of secretory IGA (SIGA) --
  • 9. Effector site of acquired immunity and T helper cell subpopulation -- 9.1 TH1 cells -- 9.2 TH2 cells -- 9.3 TH17 cells -- 9.4 TFH cells --
  • 10. Immune regulatory system and oral tolerance -- 10.1 Regulatory T cells (Tregs) -- 10.2 Oral tolerance and induction of tolerance by Tregs --
  • 11. Food allergy and celiac disease -- 11.1 Food allergy (food intolerance) -- 11.2 Allergic eosinophilic gastroenteritis (AEG) -- 11.3 Celiac disease (gluten-induced enteropathy) -- 11.3.1 Etiology -- 11.3.2 Clinical presentation and diagnosis -- 11.3.3 Treatment --
  • 12. Inflammatory bowel diseases -- 12.1 Clinical features of UC and CD -- 12.2 Immunological abnormalities in UC and CD -- 12.2.1 Changes in intestinal bacterial flora -- 12.2.2 Are there any specific immunological disorders for CD vs. UC? -- 12.2.3 Leukocyte recruitment and adhesion molecules in IBD -- 12.2.4 Genetic susceptibility and decreased mucosal regulation -- 12.3 Treatment of UC and CD from the standpoint of immunological disturbances --
  • 13. Enteric infection with pathogenic microbes and mucosal immunity -- 13.1 Mucosal immune response by pathogenic bacteria and vaccines -- 13.2 Symbiotic relationship with intestinal flora and its usefulness for immune defense against pathogenic microbes --
  • References
Control code
201107ISP025
Dimensions
unknown
Extent
1 electronic text (ix, 112 p.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615041442
Other physical details
ill., digital file
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

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