Coverart for item
The Resource Membrane transporters in drug discovery and development : methods and protocols, edited by Qing Yan, (electronic book)

Membrane transporters in drug discovery and development : methods and protocols, edited by Qing Yan, (electronic book)

Label
Membrane transporters in drug discovery and development : methods and protocols
Title
Membrane transporters in drug discovery and development
Title remainder
methods and protocols
Statement of responsibility
edited by Qing Yan
Contributor
Subject
Language
eng
Summary
Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular Biology series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field
Member of
Cataloging source
GW5XE
Dewey number
615.7
Illustrations
illustrations
Index
index present
LC call number
RM301.55
LC item number
.M46 2010
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorDate
1971-
http://library.link/vocab/relatedWorkOrContributorName
Yan, Qing
Series statement
  • Springer protocols
  • Methods in molecular biology
Series volume
v. 637
http://library.link/vocab/subjectName
  • Drugs
  • Carrier proteins
  • Membrane Transport Proteins
  • Biological Transport
  • Drug Discovery
  • Drug Carriers
Label
Membrane transporters in drug discovery and development : methods and protocols, edited by Qing Yan, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Membrane transporters and drug development : relevance to pharmacogenomics, nutrigenomics, epigenetics, and systems biology / Qing Yan -- Bioinformatics for transporter pharmacogenomics and systems biology : data integration and modeling with UML / Qing Yan -- Multidrug resistance : phylogenetic characterization of superfamilies of secondary carriers that include drug exporters / Ming Ren Yen [and others] -- Targeting drug transporters--combining in silico and in vitro approaches to predict in vivo / Praveen M. Bahadduri [and others] -- Methods to evaluate transporter activity in cancer / Takeo Nakanishi, Douglas D. Ross, and Keisuke Mitsuoka -- Analysis of expression of drug resistance-linked ABC transporters in cancer cells by quantitative RT-PCR / Anna Maria Calcagno and Suresh V. Ambudkar -- Fluorescence studies of drug binding and translocation by membrane transporters / Frances J. Sharom, Ronghua Liu, and Balpreet Vinepal -- A model for transport studies of the blood-brain barrier / Dennis J. Bobilya -- Genetic variants in the vesicular monoamine transporter 1 (VMAT1/SLC18A1) and neuropsychiatric disorders / Falk W. Lohoff -- Equilibrium binding and transport by vesicular acetylcholine transporter / Parul Khare [and others] -- ABC transporters in ophthalmic disease / Corey Westerfeld -- Imaging of protein translocation in situ in skeletal muscle of living mice / Hans P.M.M. Lauritzen -- Glucose transporters in parasitic protozoa / Scott M. Landfear -- NMR studies of membrane proteins / Gabriel A. Cook and Stanley J. Opella -- Site-directed mutagenesis in the study of membrane transporters / Andra A. McKinzie, Renae M. Ryan, and Robert J. Vandenberg -- Xenopus laevis oocytes / Stefan Bröer -- Measurement of Intracellular pH / Frederick B. Loiselle and Joseph R. Casey -- Measurement of plasma membrane calcium-calmodulin-dependent ATPase (PMCA) activity / Tamer M.A. Mohamed [and others] -- Assessment of the contribution of the plasma membrane calcium ATPase, PMCA, calcium transporter to synapse function using patch clamp electrophysiology and fast calcium imaging / Chris J. Roome and Ruth M. Empson
Control code
SPR658853804
Dimensions
unknown
Extent
1 online resource (xiii, 363 pages)
Form of item
online
Isbn
9781607617006
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-60761-700-6
Other physical details
illustrations.
Reproduction note
Electronic resource.
Specific material designation
remote
Label
Membrane transporters in drug discovery and development : methods and protocols, edited by Qing Yan, (electronic book)
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Membrane transporters and drug development : relevance to pharmacogenomics, nutrigenomics, epigenetics, and systems biology / Qing Yan -- Bioinformatics for transporter pharmacogenomics and systems biology : data integration and modeling with UML / Qing Yan -- Multidrug resistance : phylogenetic characterization of superfamilies of secondary carriers that include drug exporters / Ming Ren Yen [and others] -- Targeting drug transporters--combining in silico and in vitro approaches to predict in vivo / Praveen M. Bahadduri [and others] -- Methods to evaluate transporter activity in cancer / Takeo Nakanishi, Douglas D. Ross, and Keisuke Mitsuoka -- Analysis of expression of drug resistance-linked ABC transporters in cancer cells by quantitative RT-PCR / Anna Maria Calcagno and Suresh V. Ambudkar -- Fluorescence studies of drug binding and translocation by membrane transporters / Frances J. Sharom, Ronghua Liu, and Balpreet Vinepal -- A model for transport studies of the blood-brain barrier / Dennis J. Bobilya -- Genetic variants in the vesicular monoamine transporter 1 (VMAT1/SLC18A1) and neuropsychiatric disorders / Falk W. Lohoff -- Equilibrium binding and transport by vesicular acetylcholine transporter / Parul Khare [and others] -- ABC transporters in ophthalmic disease / Corey Westerfeld -- Imaging of protein translocation in situ in skeletal muscle of living mice / Hans P.M.M. Lauritzen -- Glucose transporters in parasitic protozoa / Scott M. Landfear -- NMR studies of membrane proteins / Gabriel A. Cook and Stanley J. Opella -- Site-directed mutagenesis in the study of membrane transporters / Andra A. McKinzie, Renae M. Ryan, and Robert J. Vandenberg -- Xenopus laevis oocytes / Stefan Bröer -- Measurement of Intracellular pH / Frederick B. Loiselle and Joseph R. Casey -- Measurement of plasma membrane calcium-calmodulin-dependent ATPase (PMCA) activity / Tamer M.A. Mohamed [and others] -- Assessment of the contribution of the plasma membrane calcium ATPase, PMCA, calcium transporter to synapse function using patch clamp electrophysiology and fast calcium imaging / Chris J. Roome and Ruth M. Empson
Control code
SPR658853804
Dimensions
unknown
Extent
1 online resource (xiii, 363 pages)
Form of item
online
Isbn
9781607617006
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-1-60761-700-6
Other physical details
illustrations.
Reproduction note
Electronic resource.
Specific material designation
remote

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