The Resource Molecular determinants of head and neck cancer, Barbara Burtness, Erica A. Golemis, editors
Molecular determinants of head and neck cancer, Barbara Burtness, Erica A. Golemis, editors
Resource Information
The item Molecular determinants of head and neck cancer, Barbara Burtness, Erica A. Golemis, editors represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Sydney Jones Library, University of Liverpool.This item is available to borrow from 1 library branch.
Resource Information
The item Molecular determinants of head and neck cancer, Barbara Burtness, Erica A. Golemis, editors represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Sydney Jones Library, University of Liverpool.
This item is available to borrow from 1 library branch.
- Summary
- This book will benefit researchers interested in better understanding the biology of squamous cell cancers of the head and neck (SCCHN), with the goals of designing therapies, identifying risk factors and investigating the molecular basis of the disease
- Language
- eng
- Edition
- Second edition.
- Extent
- 1 online resource.
- Contents
-
- Intro; Contents; Chapter 1: Overview: The Pathobiology of Head and Neck Cancer; References; Chapter 2: Targeting the ErbB Family in Head and Neck Cancer; 2.1 Introduction; 2.2 Regulation of EGFR and the ErbB Family in Normal Cells; 2.2.1 Ligand Binding and Dimerization: Activation of ErbB Proteins in Normal Cells; 2.2.2 ErbB Trafficking and Other Mechanisms to Limit EGFR Function in Normal Cells; 2.3 Causes and Consequences of Altered EGFR/ErbB Function in SCCHN; 2.3.1 Overexpression of EGFR and Its Ligands
- 2.4.3 Targeting Critical EGFR/ErbB Effectors2.4.4 EGFR/ErbB2 and Immunotherapy/Immune Response; 2.5 Mechanisms of Resistance to Anti-EGFR Therapies; 2.5.1 EGFR-Intrinsic Resistance; 2.5.2 Elevated Expression of ErbB Family Members; 2.5.3 VEGF Expression; 2.5.4 STAT3 Expression; 2.5.5 KRAS and PI3K Mutation; 2.5.6 Microenvironment; 2.5.7 Epigenetic Changes; 2.5.8 Other Factors; 2.6 Toxicity and Tolerance; 2.7 Conclusions and New Frontiers in Drug Discovery; References; Chapter 3: c-MET in Head and Neck Squamous Cell Carcinoma; 3.1 Introduction; 3.2 c-MET Structure and Normal Function
- 3.2.1 c-MET General Structure3.2.2 c-MET Ligand: HGF/SF; 3.2.3 c-MET Trafficking; 3.2.4 c-MET-Associated Signaling; 3.3 c-MET Critical Interactions and Functions; 3.3.1 c-MET and the Epidermal Growth Factor (EGF) Family of Receptors; 3.3.2 c-MET and SRC; 3.3.3 c-MET in Epithelial-to-Mesenchymal Transition (EMT); 3.4 Dysregulation of HGF/c-MET in HNSCC; 3.4.1 c-MET Overexpression and Amplification; 3.4.2 c-MET Mutation; 3.4.3 Microenvironment and HGF/SF; 3.5 Clinical Applications of HGF/c-MET-Targeted Therapy; 3.5.1 Foretinib; 3.5.2 Tivantinib; 3.5.3 Additional Small-Molecule Inhibitors
- Isbn
- 9783319787619
- Label
- Molecular determinants of head and neck cancer
- Title
- Molecular determinants of head and neck cancer
- Statement of responsibility
- Barbara Burtness, Erica A. Golemis, editors
- Language
- eng
- Summary
- This book will benefit researchers interested in better understanding the biology of squamous cell cancers of the head and neck (SCCHN), with the goals of designing therapies, identifying risk factors and investigating the molecular basis of the disease
- Cataloging source
- N$T
- Dewey number
- 616.99/491
- Index
- no index present
- LC call number
- RC280.H4
- Literary form
- non fiction
- Nature of contents
- dictionaries
- http://library.link/vocab/relatedWorkOrContributorName
-
- Burtness, Barbara
- Golemis, Erica
- Series statement
- Current cancer research
- http://library.link/vocab/subjectName
-
- Head
- Neck
- Head
- Neck
- Label
- Molecular determinants of head and neck cancer, Barbara Burtness, Erica A. Golemis, editors
- Antecedent source
- unknown
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
-
- Intro; Contents; Chapter 1: Overview: The Pathobiology of Head and Neck Cancer; References; Chapter 2: Targeting the ErbB Family in Head and Neck Cancer; 2.1 Introduction; 2.2 Regulation of EGFR and the ErbB Family in Normal Cells; 2.2.1 Ligand Binding and Dimerization: Activation of ErbB Proteins in Normal Cells; 2.2.2 ErbB Trafficking and Other Mechanisms to Limit EGFR Function in Normal Cells; 2.3 Causes and Consequences of Altered EGFR/ErbB Function in SCCHN; 2.3.1 Overexpression of EGFR and Its Ligands
- 2.4.3 Targeting Critical EGFR/ErbB Effectors2.4.4 EGFR/ErbB2 and Immunotherapy/Immune Response; 2.5 Mechanisms of Resistance to Anti-EGFR Therapies; 2.5.1 EGFR-Intrinsic Resistance; 2.5.2 Elevated Expression of ErbB Family Members; 2.5.3 VEGF Expression; 2.5.4 STAT3 Expression; 2.5.5 KRAS and PI3K Mutation; 2.5.6 Microenvironment; 2.5.7 Epigenetic Changes; 2.5.8 Other Factors; 2.6 Toxicity and Tolerance; 2.7 Conclusions and New Frontiers in Drug Discovery; References; Chapter 3: c-MET in Head and Neck Squamous Cell Carcinoma; 3.1 Introduction; 3.2 c-MET Structure and Normal Function
- 3.2.1 c-MET General Structure3.2.2 c-MET Ligand: HGF/SF; 3.2.3 c-MET Trafficking; 3.2.4 c-MET-Associated Signaling; 3.3 c-MET Critical Interactions and Functions; 3.3.1 c-MET and the Epidermal Growth Factor (EGF) Family of Receptors; 3.3.2 c-MET and SRC; 3.3.3 c-MET in Epithelial-to-Mesenchymal Transition (EMT); 3.4 Dysregulation of HGF/c-MET in HNSCC; 3.4.1 c-MET Overexpression and Amplification; 3.4.2 c-MET Mutation; 3.4.3 Microenvironment and HGF/SF; 3.5 Clinical Applications of HGF/c-MET-Targeted Therapy; 3.5.1 Foretinib; 3.5.2 Tivantinib; 3.5.3 Additional Small-Molecule Inhibitors
- Dimensions
- unknown
- Edition
- Second edition.
- Extent
- 1 online resource.
- File format
- unknown
- Form of item
- online
- Isbn
- 9783319787619
- Level of compression
- unknown
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
-
- on1047959917
- (OCoLC)1047959917
- Label
- Molecular determinants of head and neck cancer, Barbara Burtness, Erica A. Golemis, editors
- Antecedent source
- unknown
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
-
- Intro; Contents; Chapter 1: Overview: The Pathobiology of Head and Neck Cancer; References; Chapter 2: Targeting the ErbB Family in Head and Neck Cancer; 2.1 Introduction; 2.2 Regulation of EGFR and the ErbB Family in Normal Cells; 2.2.1 Ligand Binding and Dimerization: Activation of ErbB Proteins in Normal Cells; 2.2.2 ErbB Trafficking and Other Mechanisms to Limit EGFR Function in Normal Cells; 2.3 Causes and Consequences of Altered EGFR/ErbB Function in SCCHN; 2.3.1 Overexpression of EGFR and Its Ligands
- 2.4.3 Targeting Critical EGFR/ErbB Effectors2.4.4 EGFR/ErbB2 and Immunotherapy/Immune Response; 2.5 Mechanisms of Resistance to Anti-EGFR Therapies; 2.5.1 EGFR-Intrinsic Resistance; 2.5.2 Elevated Expression of ErbB Family Members; 2.5.3 VEGF Expression; 2.5.4 STAT3 Expression; 2.5.5 KRAS and PI3K Mutation; 2.5.6 Microenvironment; 2.5.7 Epigenetic Changes; 2.5.8 Other Factors; 2.6 Toxicity and Tolerance; 2.7 Conclusions and New Frontiers in Drug Discovery; References; Chapter 3: c-MET in Head and Neck Squamous Cell Carcinoma; 3.1 Introduction; 3.2 c-MET Structure and Normal Function
- 3.2.1 c-MET General Structure3.2.2 c-MET Ligand: HGF/SF; 3.2.3 c-MET Trafficking; 3.2.4 c-MET-Associated Signaling; 3.3 c-MET Critical Interactions and Functions; 3.3.1 c-MET and the Epidermal Growth Factor (EGF) Family of Receptors; 3.3.2 c-MET and SRC; 3.3.3 c-MET in Epithelial-to-Mesenchymal Transition (EMT); 3.4 Dysregulation of HGF/c-MET in HNSCC; 3.4.1 c-MET Overexpression and Amplification; 3.4.2 c-MET Mutation; 3.4.3 Microenvironment and HGF/SF; 3.5 Clinical Applications of HGF/c-MET-Targeted Therapy; 3.5.1 Foretinib; 3.5.2 Tivantinib; 3.5.3 Additional Small-Molecule Inhibitors
- Dimensions
- unknown
- Edition
- Second edition.
- Extent
- 1 online resource.
- File format
- unknown
- Form of item
- online
- Isbn
- 9783319787619
- Level of compression
- unknown
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
-
- on1047959917
- (OCoLC)1047959917
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.liverpool.ac.uk/portal/Molecular-determinants-of-head-and-neck-cancer/Q1Fi82OQDYM/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.liverpool.ac.uk/portal/Molecular-determinants-of-head-and-neck-cancer/Q1Fi82OQDYM/">Molecular determinants of head and neck cancer, Barbara Burtness, Erica A. Golemis, editors</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.liverpool.ac.uk/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.liverpool.ac.uk/">Sydney Jones Library, University of Liverpool</a></span></span></span></span></div>
