The Resource Parenteral drug treatments for acute migraine headache, contributing authors, Rebecca N. Gray ... [et al.], (electronic book)

Parenteral drug treatments for acute migraine headache, contributing authors, Rebecca N. Gray ... [et al.], (electronic book)

Label
Parenteral drug treatments for acute migraine headache
Title
Parenteral drug treatments for acute migraine headache
Statement of responsibility
contributing authors, Rebecca N. Gray ... [et al.]
Contributor
Subject
Language
  • eng
  • eng
Summary
OBJECTIVES: To identify and summarize evidence from controlled trials on the efficacy and tolerability of parenteral drug treatments for acute migraine headache. SEARCH STRATEGY: A strategy combining the MeSH term "headache" (exploded) and a previously published strategy for identifying randomized controlled trials was on the January 1966 to December 1996 MEDLINE database. Other computerized bibliographic databases, textbooks, and experts were also utilized. SELECTION CRITERIA: English-language controlled trials involving patients with acute migraine headache in which at least one treatment offered was a parenterally administered drug treatment were selected. Subcutaneous treatments delivered with an autoinjector designed for self-administration are considered in a companion report. DATA COLLECTION AND ANALYSIS: The number of patients obtaining headache relief according to an a priori definition of at least a 50% reduction in pain severity was recorded and used to calculate odds ratios for headache relief. Measures of pain severity reported as group means (and standard deviations) were used to calculate standardized mean differences (or effect sizes). Where similar trials provided data, meta-analysis of efficacy measures was performed. MAIN RESULTS: Controlled trials provide limited support for the efficacy of a number of parenteral treatments, including antinauseants (prochlorperazine and metoclopramide), NSAIDs (diclofenac), and opiate analgesics (butorphanol and methadone). Weaker evidence supports the efficacy of dihydroergotamine (DHE). The principal adverse effects observed were nausea (DHE and opiates) and sedation (opiates and antinauseants). CONCLUSIONS: Several parenteral drugs appear to be effective for the treatment of acute migraine. The evidence supporting their efficacy is, however, limited by the small number of placebo comparisons; the small size of most trials; and the diversity of settings, diagnostic criteria, and outcome measures used. The inconclusive comparisons among classes of drugs and individual agents suggest that the choice among parenteral alternatives for the treatment of acute migraine may, for the present, depend more on side effects and contraindications than on data about efficacy
Member of
Additional physical form
Issued also in print.
Cataloging source
DNLM
Government publication
federal national government publication
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Gray, Rebecca N
  • United States
Series statement
Technical reviews
Series volume
2.5
http://library.link/vocab/subjectName
  • Migraine Disorders
  • Headache
  • Acute Disease
  • Drug Administration Routes
  • Randomized Controlled Trials as Topic
  • United States
Label
Parenteral drug treatments for acute migraine headache, contributing authors, Rebecca N. Gray ... [et al.], (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
1554789
Dimensions
unknown
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
Label
Parenteral drug treatments for acute migraine headache, contributing authors, Rebecca N. Gray ... [et al.], (electronic book)
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
1554789
Dimensions
unknown
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote

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