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The Resource Pathogenesis of idiopathic scoliosis, Masafumi Machida, Stuart L. Weinstein, Jean Dubousset, editors

Pathogenesis of idiopathic scoliosis, Masafumi Machida, Stuart L. Weinstein, Jean Dubousset, editors

Label
Pathogenesis of idiopathic scoliosis
Title
Pathogenesis of idiopathic scoliosis
Statement of responsibility
Masafumi Machida, Stuart L. Weinstein, Jean Dubousset, editors
Contributor
Editor
Subject
Language
eng
Summary
This book provides comprehensive coverage of current topics in idiopathic scoliosis (IS). A three-dimensional deformity of the spine, the condition is characterized by lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. Although the clinical manifestations of scoliosis have been well documented, its cause and pathogenesis have not yet been determined. Research into what causes IS has focused on the structural elements of the spine, spinal musculature, collagenous structures, the endocrine system, the central nervous system, and genetics. Results of these studies have brought about a new perception of IS epiphenomena, but the main cause of IS remains unknown. Recently, several investigators have produced new hypotheses regarding the cause of IS using the developing techniques of genetics, biochemistry, and neurology. This book is a review of the various causative factors thus far proposed for IS and an introduction to the directions in which research is heading to determine the primary cause of IS
Cataloging source
GW5XE
Dewey number
616.7/3
Illustrations
illustrations
Index
no index present
LC call number
RD771.S3
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Machida, Masafumi
  • Weinstein, Stuart L.
  • Dubousset, Jean
http://library.link/vocab/subjectName
  • Scoliosis
  • Medicine & Public Health
  • Orthopedics
  • Pathology
  • Neurology
Label
Pathogenesis of idiopathic scoliosis, Masafumi Machida, Stuart L. Weinstein, Jean Dubousset, editors
Instantiates
Publication
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Intro; Foreword; Preface; Contents; Chapter 1: Definition of Adolescent Idiopathic Scoliosis; 1.1 Introduction; 1.1.1 First Statement; 1.1.2 Second Statement; 1.1.3 Third Statement; 1.2 Scoliosis; 1.2.1 Conclusion; 1.3 Adolescent Scoliosis; 1.4 Idiopathic Scoliosis; 1.5 Classification of Adolescent Idiopathic Scoliosis; 1.6 Personal Conclusion; References; Chapter 2: Adolescent Idiopathic Scoliosis: Natural History; 2.1 Introduction; 2.2 Etiopathogenesis; 2.3 Prevalence; 2.4 Diagnosis; 2.5 Early Studies on Patient Outcomes; 2.6 Curve Progression; 2.6.1 Skeletal Maturity
  • 2.6.1.1 Curve Factors2.6.1.2 Growth Factors; 2.6.2 Curve Location; 2.7 Back Pain and Disability; 2.8 Pulmonary Function; 2.9 Mortality; 2.10 Psychosocial Effects; 2.11 Pregnancy; 2.12 Summary; References; Chapter 3: The Genetic Architecture of Adolescent Idiopathic Scoliosis; 3.1 Introduction; 3.2 Epidemiology and Inheritance: How Common and â#x80;#x9C;Geneticâ#x80;#x9D; Is AIS?; 3.3 AIS: A Disease of Bone, Muscle, Nerve, or Cartilage?; 3.4 Identifying AIS Genes in Humans: Mapping Susceptibility Loci; 3.4.1 Family-Based Studies; 3.4.2 Population-Based Studies
  • 3.4.3 Population-Based Studies of Rare Mutations3.4.4 Chromosomal Breakpoint Mapping; 3.5 Candidate Genes and AIS Etiology; 3.5.1 LBX1; 3.5.2 GPR126; 3.5.3 BNC2; 3.5.4 PAX1 and PAX3; 3.5.5 SOX9; 3.5.6 Other Genes; 3.6 AIS Candidate Genes from Model Systems; 3.6.1 PTK7; 3.6.2 KIF6; 3.7 Quantitative Analyses: Do Genetic Factors Influence Disease Course?; 3.8 AIS Genetics: Ongoing and Future Research; 3.8.1 Genomic Studies; 3.8.2 Epigenetics; 3.8.3 Disease Modeling in Animals; 3.9 Summary; References; Chapter 4: Biomechanics of Adolescent Idiopathic Scoliosis; 4.1 Introduction
  • 4.1.1 Principles of 3D Reconstruction from Biplanar X-rays4.1.2 Clinical Relevance of 3D Reconstruction from Biplanar X-rays; 4.2 Focus on Vertebrae and Intervertebral Discs; 4.2.1 Vertebrae; 4.2.2 Intervertebral Discs; 4.2.2.1 Normal Intervertebral Discs; 4.2.2.2 Disc Alterations in Scoliosis; 4.2.2.3 Intervertebral Disc Characterization In Vivo; 4.3 Biomechanical Modeling and AIS; 4.3.1 Spine Biomechanical Models; 4.3.2 Clinical Relevance of Spine Biomechanical Models; 4.3.2.1 Mechanism of Curve Progression; 4.3.2.2 Modeling of Brace Correction
  • 4.3.2.3 Modeling of Surgical Correction4.4 Conclusion; References; Chapter 5: Biochemistry of Idiopathic Scoliosis: From Discovery to Diagnostic Biomarkers; 5.1 Introduction; 5.2 Biochemical Factors; 5.2.1 Hormonal Factors; 5.2.1.1 Growth Hormone; 5.2.1.2 Estrogens; 5.2.1.3 Leptin; 5.2.1.4 Ghrelin; 5.2.1.5 Melatonin; 5.2.2 Systemic Factors; 5.2.2.1 G Inhibitory Proteins; 5.2.2.2 Osteopontin; 5.2.3 Hematological factors (Platelet Regulatory Factors); 5.2.3.1 Calmodulin; 5.2.4 Bone Metabolism Factors; 5.2.4.1 Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL)
Control code
SPR1024316380
Dimensions
unknown
Extent
1 online resource (ix, 188 pages)
File format
unknown
Form of item
online
Isbn
9784431565413
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-4-431-56541-3
Other physical details
illustrations (some color)
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • on1024316380
  • (OCoLC)1024316380
Label
Pathogenesis of idiopathic scoliosis, Masafumi Machida, Stuart L. Weinstein, Jean Dubousset, editors
Publication
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Intro; Foreword; Preface; Contents; Chapter 1: Definition of Adolescent Idiopathic Scoliosis; 1.1 Introduction; 1.1.1 First Statement; 1.1.2 Second Statement; 1.1.3 Third Statement; 1.2 Scoliosis; 1.2.1 Conclusion; 1.3 Adolescent Scoliosis; 1.4 Idiopathic Scoliosis; 1.5 Classification of Adolescent Idiopathic Scoliosis; 1.6 Personal Conclusion; References; Chapter 2: Adolescent Idiopathic Scoliosis: Natural History; 2.1 Introduction; 2.2 Etiopathogenesis; 2.3 Prevalence; 2.4 Diagnosis; 2.5 Early Studies on Patient Outcomes; 2.6 Curve Progression; 2.6.1 Skeletal Maturity
  • 2.6.1.1 Curve Factors2.6.1.2 Growth Factors; 2.6.2 Curve Location; 2.7 Back Pain and Disability; 2.8 Pulmonary Function; 2.9 Mortality; 2.10 Psychosocial Effects; 2.11 Pregnancy; 2.12 Summary; References; Chapter 3: The Genetic Architecture of Adolescent Idiopathic Scoliosis; 3.1 Introduction; 3.2 Epidemiology and Inheritance: How Common and â#x80;#x9C;Geneticâ#x80;#x9D; Is AIS?; 3.3 AIS: A Disease of Bone, Muscle, Nerve, or Cartilage?; 3.4 Identifying AIS Genes in Humans: Mapping Susceptibility Loci; 3.4.1 Family-Based Studies; 3.4.2 Population-Based Studies
  • 3.4.3 Population-Based Studies of Rare Mutations3.4.4 Chromosomal Breakpoint Mapping; 3.5 Candidate Genes and AIS Etiology; 3.5.1 LBX1; 3.5.2 GPR126; 3.5.3 BNC2; 3.5.4 PAX1 and PAX3; 3.5.5 SOX9; 3.5.6 Other Genes; 3.6 AIS Candidate Genes from Model Systems; 3.6.1 PTK7; 3.6.2 KIF6; 3.7 Quantitative Analyses: Do Genetic Factors Influence Disease Course?; 3.8 AIS Genetics: Ongoing and Future Research; 3.8.1 Genomic Studies; 3.8.2 Epigenetics; 3.8.3 Disease Modeling in Animals; 3.9 Summary; References; Chapter 4: Biomechanics of Adolescent Idiopathic Scoliosis; 4.1 Introduction
  • 4.1.1 Principles of 3D Reconstruction from Biplanar X-rays4.1.2 Clinical Relevance of 3D Reconstruction from Biplanar X-rays; 4.2 Focus on Vertebrae and Intervertebral Discs; 4.2.1 Vertebrae; 4.2.2 Intervertebral Discs; 4.2.2.1 Normal Intervertebral Discs; 4.2.2.2 Disc Alterations in Scoliosis; 4.2.2.3 Intervertebral Disc Characterization In Vivo; 4.3 Biomechanical Modeling and AIS; 4.3.1 Spine Biomechanical Models; 4.3.2 Clinical Relevance of Spine Biomechanical Models; 4.3.2.1 Mechanism of Curve Progression; 4.3.2.2 Modeling of Brace Correction
  • 4.3.2.3 Modeling of Surgical Correction4.4 Conclusion; References; Chapter 5: Biochemistry of Idiopathic Scoliosis: From Discovery to Diagnostic Biomarkers; 5.1 Introduction; 5.2 Biochemical Factors; 5.2.1 Hormonal Factors; 5.2.1.1 Growth Hormone; 5.2.1.2 Estrogens; 5.2.1.3 Leptin; 5.2.1.4 Ghrelin; 5.2.1.5 Melatonin; 5.2.2 Systemic Factors; 5.2.2.1 G Inhibitory Proteins; 5.2.2.2 Osteopontin; 5.2.3 Hematological factors (Platelet Regulatory Factors); 5.2.3.1 Calmodulin; 5.2.4 Bone Metabolism Factors; 5.2.4.1 Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL)
Control code
SPR1024316380
Dimensions
unknown
Extent
1 online resource (ix, 188 pages)
File format
unknown
Form of item
online
Isbn
9784431565413
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-4-431-56541-3
Other physical details
illustrations (some color)
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • on1024316380
  • (OCoLC)1024316380

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