Coverart for item
The Resource Perinatal brain development, malformation, and injury, Juliet K. Knowles, Anna A. Penn, (electronic book)

Perinatal brain development, malformation, and injury, Juliet K. Knowles, Anna A. Penn, (electronic book)

Label
Perinatal brain development, malformation, and injury
Title
Perinatal brain development, malformation, and injury
Statement of responsibility
Juliet K. Knowles, Anna A. Penn
Creator
Contributor
Subject
Language
eng
Summary
We provide a broad overview of human brain development with associated malformations and injuries that occur in the period between early embryogenesis and delivery. The aim of this review is to summarize current understanding of the molecular and environmental cues that shape the developing brain. For each developmental stage, we give examples of disorders that arise from genetic and/or environmental insults to illustrate critical points of neurological susceptibility
Member of
Cataloging source
CaBNVSL
http://library.link/vocab/creatorName
Knowles, Juliet K
Dewey number
612.8
Illustrations
illustrations
Index
no index present
LC call number
QP363.5
LC item number
.K566 2012
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Penn, Anna Asher.
http://library.link/vocab/subjectName
  • Developmental neurobiology
  • Brain
  • Brain
Target audience
  • adult
  • specialized
Label
Perinatal brain development, malformation, and injury, Juliet K. Knowles, Anna A. Penn, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 67-73)
Color
multicolored
Contents
  • 1. Introduction --
  • 2. Origin of the central nervous system: the neural tube (3-4 weeks gestation) -- 2.1 Neurulation -- 2.1.1 Molecular mechanisms of neurulation -- 2.1.2 Molecular mechanisms of neural tube closure: Wnts and hedghog proteins -- 2.1.3 Neural tube defects -- 2.1.4 Etiology of neural tube disorders: genetics and environment collide -- 2.1.4.1 Shh and Wnt mutations -- 2.1.5 Folate metabolism -- 2.2 Summary: neurulation and NTDs --
  • 3. Patterning of the neural tube: a blueprint for the CNS -- 3.1 Dorso-ventral patterning of the neural tube -- 3.2 Rostro-Caudal patterning of the neural tube -- 3.3 Prosencephalic cleavage and midline development -- 3.4 Midline defects: holoprosencephaly, agenesis of the corpus callosum, and Dandy-Walker malformation -- 3.4.1 Holoprosencephaly -- 3.4.2 Agenesis of the corpus callosum -- 3.4.3 Dandy-Walker malformation -- 3.5 Genetics and environment collide again to generate these midline alterations -- 3.6 Summary: CNS patterning and midline defects --
  • 4. Neural proliferation and migration (3 months gestation into postnatal period) -- 4.1 Neurogenesis -- 4.2 Programmed cell death -- 4.3 Microcephaly vera: deficient neurogenesis -- 4.4 Neuronal migration -- 4.5 Disordered migration: lissencephaly and LIS1 -- 4.6 Summary: neural proliferation and migration --
  • 5. Organization of neuronal circuits and synaptogenesis (5 months gestation-postnatal years) -- 5.1 Wiring up the brain: axon path finding between brain regions -- 5.2 The role of subplate neurons in defining the gross structure of circuits -- 5.3 Synaptogenesis and critical periods: fine control of circuits -- 5.4 Immune molecules and circuit refinement -- 5.5 Impaired synapse formation: fragile X -- 5.6 Summary: neuronal circuits and synaptogenesis --
  • 6. Gliogenesis and myelination (5-month childhood) -- 6.1 Glial proliferation -- 6.2 Astrogenesis -- 6.3 Oligogliogenesis and myelin formation -- 6.4 Microglia -- 6.5 Summary: gliogenesis --
  • 7. Developmental brain injury: before, during, and after birth -- 7.1 Neonatal encephalopathy -- 7.2 Risk factors for injury before birth: compromised placental function and infection -- 7.3 Injury in the preterm brain -- 7.3.1 Periventricular leukomalacia -- 7.3.2 Intraventricular hemorrhage -- 7.4 Injury in the term brain -- 7.4.1 Hypoxia-ischemia -- 7.4.2 Stroke -- 7.5 Summary: brain injury --
  • 8. Conclusion -- References -- Author biographies
Control code
201109DBR006
Dimensions
unknown
Extent
1 electronic text (viii, 75 p.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615043439
Other physical details
ill., digital file.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
Perinatal brain development, malformation, and injury, Juliet K. Knowles, Anna A. Penn, (electronic book)
Publication
Bibliography note
Includes bibliographical references (p. 67-73)
Color
multicolored
Contents
  • 1. Introduction --
  • 2. Origin of the central nervous system: the neural tube (3-4 weeks gestation) -- 2.1 Neurulation -- 2.1.1 Molecular mechanisms of neurulation -- 2.1.2 Molecular mechanisms of neural tube closure: Wnts and hedghog proteins -- 2.1.3 Neural tube defects -- 2.1.4 Etiology of neural tube disorders: genetics and environment collide -- 2.1.4.1 Shh and Wnt mutations -- 2.1.5 Folate metabolism -- 2.2 Summary: neurulation and NTDs --
  • 3. Patterning of the neural tube: a blueprint for the CNS -- 3.1 Dorso-ventral patterning of the neural tube -- 3.2 Rostro-Caudal patterning of the neural tube -- 3.3 Prosencephalic cleavage and midline development -- 3.4 Midline defects: holoprosencephaly, agenesis of the corpus callosum, and Dandy-Walker malformation -- 3.4.1 Holoprosencephaly -- 3.4.2 Agenesis of the corpus callosum -- 3.4.3 Dandy-Walker malformation -- 3.5 Genetics and environment collide again to generate these midline alterations -- 3.6 Summary: CNS patterning and midline defects --
  • 4. Neural proliferation and migration (3 months gestation into postnatal period) -- 4.1 Neurogenesis -- 4.2 Programmed cell death -- 4.3 Microcephaly vera: deficient neurogenesis -- 4.4 Neuronal migration -- 4.5 Disordered migration: lissencephaly and LIS1 -- 4.6 Summary: neural proliferation and migration --
  • 5. Organization of neuronal circuits and synaptogenesis (5 months gestation-postnatal years) -- 5.1 Wiring up the brain: axon path finding between brain regions -- 5.2 The role of subplate neurons in defining the gross structure of circuits -- 5.3 Synaptogenesis and critical periods: fine control of circuits -- 5.4 Immune molecules and circuit refinement -- 5.5 Impaired synapse formation: fragile X -- 5.6 Summary: neuronal circuits and synaptogenesis --
  • 6. Gliogenesis and myelination (5-month childhood) -- 6.1 Glial proliferation -- 6.2 Astrogenesis -- 6.3 Oligogliogenesis and myelin formation -- 6.4 Microglia -- 6.5 Summary: gliogenesis --
  • 7. Developmental brain injury: before, during, and after birth -- 7.1 Neonatal encephalopathy -- 7.2 Risk factors for injury before birth: compromised placental function and infection -- 7.3 Injury in the preterm brain -- 7.3.1 Periventricular leukomalacia -- 7.3.2 Intraventricular hemorrhage -- 7.4 Injury in the term brain -- 7.4.1 Hypoxia-ischemia -- 7.4.2 Stroke -- 7.5 Summary: brain injury --
  • 8. Conclusion -- References -- Author biographies
Control code
201109DBR006
Dimensions
unknown
Extent
1 electronic text (viii, 75 p.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615043439
Other physical details
ill., digital file.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

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