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The Resource Reactive oxygen species and the cardiovascular system, Augusto C. Montezano and Rhian M. Touyz, (electronic book)

Reactive oxygen species and the cardiovascular system, Augusto C. Montezano and Rhian M. Touyz, (electronic book)

Label
Reactive oxygen species and the cardiovascular system
Title
Reactive oxygen species and the cardiovascular system
Statement of responsibility
Augusto C. Montezano and Rhian M. Touyz
Creator
Contributor
Subject
Language
eng
Summary
Reactive oxygen species (ROS) influence various physiological processes including host defense, hormone biosynthesis, and cellular signaling. Increased ROS production (oxidative stress) is implicated in many diseases of the cardiovascular system, including hypertension, atherosclerosis, cardiac failure, stroke, diabetes, and kidney disease. ROS are produced throughout the cardiovascular system, in the kidney and central and peripheral nervous system. A major source for cardiovascular, renal, and neural ROS is a family of non-phagocytic NAD(P)H oxidases, including the prototypic Nox2 homologue-based NAD(P)H oxidase, as well as other NAD(P)H oxidases, such as Nox1 and Nox4. Other possible sources include mitochondrial electron transport enzymes, xanthine oxidase, cyclooxygenase, lipoxygenase, and uncoupled nitric oxide synthase (NOS). NAD(P)H oxidasederived ROS is important in regulating endothelial function and vascular tone and oxidative stress is implicated in endothelial dysfunction, inflammation, hypertrophy, apoptosis, migration, fibrosis, angiogenesis and rarefaction, important processes involved in vascular remodeling in cardiovascular disease. These findings have evoked considerable interest because of the possibilities that therapies targeted against non-phagocytic NAD(P)H oxidase to decrease ROS generation and/or strategies to increase nitric oxide (NO) availability and antioxidants may be useful in minimizing vascular injury and thereby prevent or regress target organ damage associated with hypertension and other cardiovascular diseases
Member of
Cataloging source
CaBNVSL
http://library.link/vocab/creatorName
Montezano, Augusto C.
Dewey number
616.042
Illustrations
illustrations
Index
no index present
LC call number
RB170
LC item number
.M657 2012
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Touyz, Rhian M.
Series statement
Colloquium series on integrated systems physiology
Series volume
32
http://library.link/vocab/subjectName
  • Active oxygen
  • Oxidative stress
Target audience
  • adult
  • specialized
Label
Reactive oxygen species and the cardiovascular system, Augusto C. Montezano and Rhian M. Touyz, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 55-91)
Color
multicolored
Contents
  • 1. Introduction --
  • 2. Redox molecules -- 2.1 Superoxide and hydrogen peroxide -- 2.2 Reactive nitrogen species (RNS) --
  • 3. Production and metabolism of ROS in the cardiovascular system -- 3.1 Xanthine oxidase -- 3.2 Uncoupled nitric oxide synthase -- 3.3 Mitochondrial respiratory enzymes -- 3.4 Nox-family NAD(P)H oxidases -- 3.4.1 Nox1 -- 3.4.2 Nox2 -- 3.4.3 Nox4 -- 3.4.4 Nox5 --
  • 4. Interactions between mitochondria and Noxs --
  • 5. Distribution of Noxes in the vascular wall --
  • 6. Regulation of Noxes --
  • 7. Protecting against oxidative stress, antioxidant defenses -- 7.1 Enzymatic antioxidants -- 7.2 Non-enzymatic antioxidants --
  • 8. How does oxidative stress cause disease? --
  • 9. Oxidative stress and hypertension -- 9.1 Production of ROS in the cardiovascular and renal systems in hypertension -- 9.2 ROS and autonomic outflow and hypertension -- 9.3 Oxidative stress in experimental hypertension -- 9.4 Oxidative stress and clinical hypertension --
  • 10. Antioxidant therapy and human hypertension --
  • 11. NADPH oxidase and Nox isoforms as therapeutic targets, clinical potential --
  • 12. Other strategies to reduce oxidative stress --
  • 13. Assessing reactive oxygen species in the cardiovascular system -- 13.1 Cytochrome C reduction -- 13.2 Lucigenin-enhanced chemiluminescence -- 13.3 Dihydroethidium and high-performance liquid chromatography -- 13.4 Dichlorofluorescein and amplex red to measure H2O2 -- 13.5 Dihydrorhodamine oxidation to measure ONOO- -- 13.6 Electron spin resonance --
  • 14. Assessing ROS in clinical studies --
  • 15. Conclusion -- Acknowledgments -- References -- Author biographies
Control code
201112ISP032
Dimensions
unknown
Extent
1 electronic text (viii, 93 p.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615043637
Other physical details
ill., digital file.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
Reactive oxygen species and the cardiovascular system, Augusto C. Montezano and Rhian M. Touyz, (electronic book)
Publication
Bibliography note
Includes bibliographical references (p. 55-91)
Color
multicolored
Contents
  • 1. Introduction --
  • 2. Redox molecules -- 2.1 Superoxide and hydrogen peroxide -- 2.2 Reactive nitrogen species (RNS) --
  • 3. Production and metabolism of ROS in the cardiovascular system -- 3.1 Xanthine oxidase -- 3.2 Uncoupled nitric oxide synthase -- 3.3 Mitochondrial respiratory enzymes -- 3.4 Nox-family NAD(P)H oxidases -- 3.4.1 Nox1 -- 3.4.2 Nox2 -- 3.4.3 Nox4 -- 3.4.4 Nox5 --
  • 4. Interactions between mitochondria and Noxs --
  • 5. Distribution of Noxes in the vascular wall --
  • 6. Regulation of Noxes --
  • 7. Protecting against oxidative stress, antioxidant defenses -- 7.1 Enzymatic antioxidants -- 7.2 Non-enzymatic antioxidants --
  • 8. How does oxidative stress cause disease? --
  • 9. Oxidative stress and hypertension -- 9.1 Production of ROS in the cardiovascular and renal systems in hypertension -- 9.2 ROS and autonomic outflow and hypertension -- 9.3 Oxidative stress in experimental hypertension -- 9.4 Oxidative stress and clinical hypertension --
  • 10. Antioxidant therapy and human hypertension --
  • 11. NADPH oxidase and Nox isoforms as therapeutic targets, clinical potential --
  • 12. Other strategies to reduce oxidative stress --
  • 13. Assessing reactive oxygen species in the cardiovascular system -- 13.1 Cytochrome C reduction -- 13.2 Lucigenin-enhanced chemiluminescence -- 13.3 Dihydroethidium and high-performance liquid chromatography -- 13.4 Dichlorofluorescein and amplex red to measure H2O2 -- 13.5 Dihydrorhodamine oxidation to measure ONOO- -- 13.6 Electron spin resonance --
  • 14. Assessing ROS in clinical studies --
  • 15. Conclusion -- Acknowledgments -- References -- Author biographies
Control code
201112ISP032
Dimensions
unknown
Extent
1 electronic text (viii, 93 p.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615043637
Other physical details
ill., digital file.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

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