Coverart for item
The Resource Regulation of cardiac contractility, R. John Solaro, (electronic book)

Regulation of cardiac contractility, R. John Solaro, (electronic book)

Label
Regulation of cardiac contractility
Title
Regulation of cardiac contractility
Statement of responsibility
R. John Solaro
Creator
Subject
Language
eng
Summary
Contractility describes the relative ability of the heart to eject a stroke volume (SV) at a given prevailing afterload (arterial pressure) and preload (end-diastolic volume; EDV). Various measures of contractility are related to the fraction as the SV/EDV or the ejection fraction, and the dynamics of ejection as determined from maximum pressure rise in the ventricles or arteries or from aortic flow velocities determined by echocardiography. At the cellular level, the ultimate determinant of contractility is the relative tension generation and shortening capability of the molecular motors (myosin cross-bridges) of the sarcomeres as determined by the rates and extent of Ca activation, the turnover kinetics of the cross-bridges, and the relative Ca responsiveness of the sarcomeres. Engagement of the regulatory signaling cascades controlling contractility occurs with occupancy and signal transduction by receptors for neurohumors of the autonomic nervous system as well as growth and stress signaling pathways. Contractility is also determined by the prevailing conditions of pH, temperature, and redox state. Short-term control of contractility is fully expressed during exercise. In long-term responses to stresses on the heart, contractility is modified by cellular remodeling and altered signaling that may compensate for a time but which ultimately may fail, leading to disorders
Member of
Cataloging source
CaBNVSL
http://library.link/vocab/creatorName
Solaro, R. John.
Dewey number
612.17
Illustrations
illustrations
Index
no index present
LC call number
QP113.2
LC item number
.S667 2011
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/subjectName
Heart
Target audience
  • adult
  • specialized
Label
Regulation of cardiac contractility, R. John Solaro, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 33)
Color
multicolored
Contents
Introduction: contractility and the integrative biology of the myocardium -- Contractility in the modern context -- Control of cardiac contractility is critical to the matching of cardiac output to venous return during exercise with little change in end diastolic volume and with tuning of the dynamics of contraction and relaxation to heart rate -- Control of contractility is at the cellular level of organization -- Left ventricular diastolic and systolic pressure, ejection, and relaxation reflect sarcomeric mechanical properties -- Integration of sarcomere mechanics with cardiac function clarifies the meaning of preload, afterload, and contractility -- Pressure volume loops provide a quantification of contractility -- Phosphorylations of regulatory proteins in excitation contraction coupling modify contractility by controlling cellular Ca2+ fluxes, the response of the myofilaments to Ca2+, and the kinetics of the cross-bridge cycle -- Contractility may be altered by a variety of mechanisms not involving a prominent role for the autonomic nervous system -- Cardiac function curves provide a compact graphical representation of regulation of CO and SV -- Heart failure as a failure of contractility -- References -- Author biography
Control code
201104ISP018
Dimensions
unknown
Extent
1 electronic text (vii, 35 p.)
File format
multiple file formats
Form of item
online
Isbn
9781615041749
Other control number
10.4199/C00030ED1V01Y201104ISP018
Other physical details
ill., digital file.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
Regulation of cardiac contractility, R. John Solaro, (electronic book)
Publication
Bibliography note
Includes bibliographical references (p. 33)
Color
multicolored
Contents
Introduction: contractility and the integrative biology of the myocardium -- Contractility in the modern context -- Control of cardiac contractility is critical to the matching of cardiac output to venous return during exercise with little change in end diastolic volume and with tuning of the dynamics of contraction and relaxation to heart rate -- Control of contractility is at the cellular level of organization -- Left ventricular diastolic and systolic pressure, ejection, and relaxation reflect sarcomeric mechanical properties -- Integration of sarcomere mechanics with cardiac function clarifies the meaning of preload, afterload, and contractility -- Pressure volume loops provide a quantification of contractility -- Phosphorylations of regulatory proteins in excitation contraction coupling modify contractility by controlling cellular Ca2+ fluxes, the response of the myofilaments to Ca2+, and the kinetics of the cross-bridge cycle -- Contractility may be altered by a variety of mechanisms not involving a prominent role for the autonomic nervous system -- Cardiac function curves provide a compact graphical representation of regulation of CO and SV -- Heart failure as a failure of contractility -- References -- Author biography
Control code
201104ISP018
Dimensions
unknown
Extent
1 electronic text (vii, 35 p.)
File format
multiple file formats
Form of item
online
Isbn
9781615041749
Other control number
10.4199/C00030ED1V01Y201104ISP018
Other physical details
ill., digital file.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

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