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The Resource Regulation of vascular smooth muscle function, Raouf A. Khalil, (electronic book)

Regulation of vascular smooth muscle function, Raouf A. Khalil, (electronic book)

Label
Regulation of vascular smooth muscle function
Title
Regulation of vascular smooth muscle function
Statement of responsibility
Raouf A. Khalil
Creator
Subject
Language
eng
Summary
Vascular smooth muscle (VSM) constitutes most of the tunica media in blood vessels and plays an important role in the control of vascular tone. Ca2+ is a major regulator of VSM contraction and is strictly regulated by an intricate system of Ca2+ mobilization and Ca2+ homeostatic mechanisms. The interaction of a physiological agonist with its plasma membrane receptor stimulates the hydrolysis of membrane phospholipids and increases the generation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 stimulates Ca2+ release from the intracellular stores in the sarcoplasmic reticulum. Agonists also stimulate Ca2+ influx from the extracellular space via voltage-gated, receptor-operated, and store-operated channels. Ca2+ homeostatic mechanisms tend to decrease the intracellular free Ca2+ concentration ([Ca2+]i) by activating Ca2+ extrusion via the plasmalemmal Ca2+ pump and the Na+/Ca2+ exchanger and the uptake of excess Ca2+ by the sarcoplasmic reticulum and possibly the mitochondria. A threshold increase in [Ca2+]i activates Ca2+-dependent myosin light chain (MLC) phosphorylation, stimulates actin-myosin interaction, and initiates VSM contraction. The agonist-induced maintained increase in DAG also activates specific protein kinase C (PKC) isoforms, which in turn cause phosphorylation of cytoplasmic substrates that increase the contractile myofilaments force sensitivity to Ca2+ and thereby enhance VSM contraction. Agonists could also activate Rho kinase (ROCK), leading to inhibition of MLC phosphatase and further enhancement of the myofilaments force sensitivity to Ca2+. The combined increases in [Ca2+]i, PKC and ROCK activity cause significant vasoconstriction and could also stimulate VSM hypertrophy and hyperplasia. The protracted and progressive activation of these processes could lead to pathological vascular remodeling and vascular disease
Member of
Cataloging source
CaBNvSL
http://library.link/vocab/creatorName
Khalil, Raouf A
Dewey number
611.0186
Illustrations
illustrations
Index
no index present
LC call number
QP110.V37
LC item number
K427 2010
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
Series statement
Colloquium series on integrated systems physiology, from molecule to function
Series volume
7
http://library.link/vocab/subjectName
  • Vascular smooth muscle
  • Muscle, Smooth, Vascular
Target audience
specialized
Label
Regulation of vascular smooth muscle function, Raouf A. Khalil, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 43-60a)
Color
multicolored
Contents
  • 1. Introduction --
  • 2. Ca2+ Release from the Intracellular Stores -- 2.1 Inositol Trisphosphate-Induced Ca2+ Release -- 2.2 Ca2+-Induced Ca2+ Release --
  • 3. Ca2+ Entry from the Extracellular Space -- 3.1 Ca2+ Leak -- 3.2 Voltage-Gated Ca2+ Channels -- 3.3 Receptor-Operated (Ligand-Gated) Ca2+ Channels -- 3.4 Store-Operated Ca2+ Channels -- 3.5 Stretch-Activated Ca2+ Channels --
  • 4. Mechanisms of Ca2+ Homeostasis -- 4.1 Plasmalemmal Ca2+-ATPase -- 4.2 The Sodium-Calcium Exchanger -- 4.3 Sarcoplasmic Reticulum Ca2+-ATPase -- 4.4 Mitochondria and Ca2+ --
  • 5. Ca2+-Dependent Myosin Light Chain Phosphorylation -- 5.1 Intracellular Free Ca2+ Concentration -- 5.2 Ca2+-Dependent Myosin Light Chain Phosphorylation -- 5.3 Evidence for Other Mechanisms of Smooth Muscle Contraction --
  • 6. Protein Kinase C -- 6.1 PKC Structure and PKC Isoforms -- 6.2 PKC Substrates -- 6.3 Tissue Distribution of PKC -- 6.4 Subcellular Distribution of PKC -- 6.5 Mechanisms of PKC Translocation -- 6.5.1 Conformation-Induced Changes in Hydrophobicity -- 6.5.2 Lipid Modification -- 6.5.3 Phosphorylation -- 6.5.4 Targeting Sequences -- 6.6 Functions of PKC in VSM -- 6.7 PKC Activators -- 6.8 PKC Inhibitors -- 6.9 Protein Kinase Cascades during VSM Contraction --
  • 7. Rho Kinase in Vascular Smooth Muscle -- 7.1 ROCK Structure and Isoforms -- 7.2 Tissue Expression of ROCK -- 7.3 Subcellular Distribution of ROCK -- 7.4 Regulation of ROCK Activity -- 7.5 ROCK Substrates -- 7.6 ROCK and VSM Function -- 7.7 Rho Kinase Inhibitors --
  • 8. Vascular Smooth Muscle Dysfunction and Vascular Disease --
  • 9. Summary -- References -- Author biography
Dimensions
unknown
Extent
1 electronic text (xii, 62 p. : ill.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615041817
Other physical details
digital file
Reformatting quality
access
Specific material designation
remote
Label
Regulation of vascular smooth muscle function, Raouf A. Khalil, (electronic book)
Publication
Bibliography note
Includes bibliographical references (p. 43-60a)
Color
multicolored
Contents
  • 1. Introduction --
  • 2. Ca2+ Release from the Intracellular Stores -- 2.1 Inositol Trisphosphate-Induced Ca2+ Release -- 2.2 Ca2+-Induced Ca2+ Release --
  • 3. Ca2+ Entry from the Extracellular Space -- 3.1 Ca2+ Leak -- 3.2 Voltage-Gated Ca2+ Channels -- 3.3 Receptor-Operated (Ligand-Gated) Ca2+ Channels -- 3.4 Store-Operated Ca2+ Channels -- 3.5 Stretch-Activated Ca2+ Channels --
  • 4. Mechanisms of Ca2+ Homeostasis -- 4.1 Plasmalemmal Ca2+-ATPase -- 4.2 The Sodium-Calcium Exchanger -- 4.3 Sarcoplasmic Reticulum Ca2+-ATPase -- 4.4 Mitochondria and Ca2+ --
  • 5. Ca2+-Dependent Myosin Light Chain Phosphorylation -- 5.1 Intracellular Free Ca2+ Concentration -- 5.2 Ca2+-Dependent Myosin Light Chain Phosphorylation -- 5.3 Evidence for Other Mechanisms of Smooth Muscle Contraction --
  • 6. Protein Kinase C -- 6.1 PKC Structure and PKC Isoforms -- 6.2 PKC Substrates -- 6.3 Tissue Distribution of PKC -- 6.4 Subcellular Distribution of PKC -- 6.5 Mechanisms of PKC Translocation -- 6.5.1 Conformation-Induced Changes in Hydrophobicity -- 6.5.2 Lipid Modification -- 6.5.3 Phosphorylation -- 6.5.4 Targeting Sequences -- 6.6 Functions of PKC in VSM -- 6.7 PKC Activators -- 6.8 PKC Inhibitors -- 6.9 Protein Kinase Cascades during VSM Contraction --
  • 7. Rho Kinase in Vascular Smooth Muscle -- 7.1 ROCK Structure and Isoforms -- 7.2 Tissue Expression of ROCK -- 7.3 Subcellular Distribution of ROCK -- 7.4 Regulation of ROCK Activity -- 7.5 ROCK Substrates -- 7.6 ROCK and VSM Function -- 7.7 Rho Kinase Inhibitors --
  • 8. Vascular Smooth Muscle Dysfunction and Vascular Disease --
  • 9. Summary -- References -- Author biography
Dimensions
unknown
Extent
1 electronic text (xii, 62 p. : ill.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615041817
Other physical details
digital file
Reformatting quality
access
Specific material designation
remote

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