The Resource Self-Administered drug treatments for acute migraine headache, contributing authors, Rebecca N. Gray ... [et al.], (electronic book)

Self-Administered drug treatments for acute migraine headache, contributing authors, Rebecca N. Gray ... [et al.], (electronic book)

Label
Self-Administered drug treatments for acute migraine headache
Title
Self-Administered drug treatments for acute migraine headache
Statement of responsibility
contributing authors, Rebecca N. Gray ... [et al.]
Contributor
Subject
Language
  • eng
  • eng
Summary
OBJECTIVE: The objective was to identify and summarize evidence from controlled trials on the efficacy and tolerability of self-administered drug treatments for acute migraine headache. SEARCH STRATEGY: A strategy combining the MeSH term "headache" (exploded) and a previously published strategy for identifying randomized controlled trials was used on the January 1966 to December 1996 MEDLINE database. Other computerized bibliographic databases, textbooks, and experts were also utilized. SELECTION CRITERIA: English-language controlled trials involving patients with acute migraine headache in which at least one treatment offered was a self-administered drug treatment were included. DATA COLLECTION AND ANALYSIS: The number of patients obtaining headache relief according to an a priori definition of at least a 50% reduction in pain severity was recorded and used to calculate odds ratios for headache relief Measures of pain severity reported as group means (and standard deviations) were used to calculate standardized mean differences (or effect sizes). Where similar trials provided data, meta-analysis of efficacy measures was performed. The identity and rates of adverse events were recorded and statistically compared. MAIN RESULTS: Placebo-controlled trials support the efficacy of a number of self-administered treatments for acute migraine, including non-steroidal anti-inflammatory drugs (NSAIDs), dihydroergotamine (DHE) nasal spray, sumatriptan (in subcutaneous, oral, and intranasal formulations), and opiate analgesics (codeine and butorphanol). Evidence supporting the efficacy of ergot alkaloids and isometheptene compounds is weaker. Comparisons among alternative drug treatments are few in number and mostly inconclusive. Controlled trials of antinauseants or caffeine used in conjunction with ergots or NSAIDs do not show a significant adjuvant effect on pain relief. Ergotamine tartrate was associated with the highest rate of adverse events, principally nausea, but concomitant administration of antinauseants or caffeine appear to improve its tolerability. CONCLUSIONS: Several self-administered drugs appear to be effective for the treatment of acute migraine. The inconclusive comparisons among classes of drugs and individual agents suggest that the choice among alternatives for the treatment of acute migraine may, for the present, depend more on side effects and contraindications than on data about efficacy
Member of
Additional physical form
Issued also in print.
Cataloging source
DNLM
Government publication
federal national government publication
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Gray, Rebecca N
Series statement
Technical reviews
Series volume
2.4
http://library.link/vocab/subjectName
  • Migraine Disorders
  • Headache
  • Acute Disease
  • Sumatriptan
  • Self Administration
  • Randomized Controlled Trials as Topic
  • United States
Label
Self-Administered drug treatments for acute migraine headache, contributing authors, Rebecca N. Gray ... [et al.], (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
1554788
Dimensions
unknown
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
Label
Self-Administered drug treatments for acute migraine headache, contributing authors, Rebecca N. Gray ... [et al.], (electronic book)
Publication
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
1554788
Dimensions
unknown
Form of item
online
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote

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