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The Resource Stroke genomics : methods and reviews, edited by Simon J. Read, David Virley, (electronic book)

Stroke genomics : methods and reviews, edited by Simon J. Read, David Virley, (electronic book)

Label
Stroke genomics : methods and reviews
Title
Stroke genomics
Title remainder
methods and reviews
Statement of responsibility
edited by Simon J. Read, David Virley
Contributor
Subject
Language
eng
Summary
"Although numerous genomic studies of stroke have examined such factors as stroke inheritance, chromosomal loci of risk, preclinical models of stroke, and differential gene expression of brain injury, repair, and recovery, much work to determine the precise role of gene function in human neurological pathophysiology remains ahead. In Stroke Genomics: Methods and Reviews, leading experts in the field explore the pragmatic application of the tools of genomic and molecular biology research to the treatment of stroke. Providing the reader with cutting-edge reviews of clinical and preclinical genomics, the authors relate changes in gene expression to physiological end points-such as functional imaging paradigms-to produce a more holistic approach in which molecular biology goes hand in hand with stroke pathophysiology. Topics of special interest include stem cell transplantation, gene therapy, clinical gene/gene interaction studies, and cytokine drug discovery. Readily reproducible techniques are provided, along with ancillary methods (imaging, animal models, human genetic study design, and transgenic animal production) that can be effectively applied to gene discovery. The protocols follow the successful Methods in Molecular Medicine series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and highly practical, Stroke Genomics: Methods and Reviews shows how to successfully design, execute, and interpret preclinical and clinical molecular biological studies of stroke, work that will greatly advance its understanding, as well as rapid development of the next generation of stroke therapeutics. Book jacket."--Jacket
Member of
Cataloging source
COO
Dewey number
616.8/1042
Illustrations
illustrations
Index
index present
LC call number
RC388.5
LC item number
.S85254 2005
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Read, Simon J
  • Virley, David
Series statement
Methods in molecular medicine,
Series volume
104
http://library.link/vocab/subjectName
  • Cerebrovascular disease
  • Cerebrovascular disease
  • Genomics
  • MEDICAL
Label
Stroke genomics : methods and reviews, edited by Simon J. Read, David Virley, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Contents
  • Introduction to stroke genomics / Simon J. Read and Frank C. Barone -- Choice, methodology, and characterization of ischemic stroke models : the search for clinical relevance / David Virley -- Mutant animal models of stroke and gene expression : the stroke prone spontaneously hypertensive rat / Hilary V.O. Carswell ... [et al.] -- Gene therapy in neurological disease / Midori A. Yenari and Robert M. Sapolsky -- Stem cell transplantation after middle cerebral artery occlusion / Paul Stroemer and Helen Hodges -- Endogenous brain protection : models, gene expression, and mechanisms / Frank C. Barone -- Production of transgenic and mutant mouse models / Alex Harper
  • 3-nitropropionic acid model of metabolic stress : assessment by magnetic resonance imaging / Toby John Roberts -- Practicalities of genetic studies in human stroke / Ahamad Hassan and Hugh S. Markus -- Evaluation of the interactions of common genetic mutations in stroke / Zoltán Szolnoki -- Technologies of disease-related gene discovery using preclinical models of stroke / Xinkang Wang -- Quantitative analysis of gene transcription in stroke models using real-time RT-PCR / David C. Harrison and Brian C. Bond -- Effective analysis of genomic data / Paul R. Nelson, Andrew B. Goulter, and Richard J. Davis -- Bioinformatic approaches to assigning protein function from novel sequence data / David Michalovich and Richard Fagan -- Pragmatic target discovery from novel gene to functionally defined drug target : the interleukin-1 story / Stuart McRae Allen
Control code
SPR61003592
Dimensions
unknown
Extent
1 online resource (x, 351 p.)
Form of item
online
Isbn
9781592598366
Other physical details
ill. (some col.)
Specific material designation
remote
Label
Stroke genomics : methods and reviews, edited by Simon J. Read, David Virley, (electronic book)
Publication
Bibliography note
Includes bibliographical references and index
Contents
  • Introduction to stroke genomics / Simon J. Read and Frank C. Barone -- Choice, methodology, and characterization of ischemic stroke models : the search for clinical relevance / David Virley -- Mutant animal models of stroke and gene expression : the stroke prone spontaneously hypertensive rat / Hilary V.O. Carswell ... [et al.] -- Gene therapy in neurological disease / Midori A. Yenari and Robert M. Sapolsky -- Stem cell transplantation after middle cerebral artery occlusion / Paul Stroemer and Helen Hodges -- Endogenous brain protection : models, gene expression, and mechanisms / Frank C. Barone -- Production of transgenic and mutant mouse models / Alex Harper
  • 3-nitropropionic acid model of metabolic stress : assessment by magnetic resonance imaging / Toby John Roberts -- Practicalities of genetic studies in human stroke / Ahamad Hassan and Hugh S. Markus -- Evaluation of the interactions of common genetic mutations in stroke / Zoltán Szolnoki -- Technologies of disease-related gene discovery using preclinical models of stroke / Xinkang Wang -- Quantitative analysis of gene transcription in stroke models using real-time RT-PCR / David C. Harrison and Brian C. Bond -- Effective analysis of genomic data / Paul R. Nelson, Andrew B. Goulter, and Richard J. Davis -- Bioinformatic approaches to assigning protein function from novel sequence data / David Michalovich and Richard Fagan -- Pragmatic target discovery from novel gene to functionally defined drug target : the interleukin-1 story / Stuart McRae Allen
Control code
SPR61003592
Dimensions
unknown
Extent
1 online resource (x, 351 p.)
Form of item
online
Isbn
9781592598366
Other physical details
ill. (some col.)
Specific material designation
remote

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