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The Resource Surface enhanced raman spectroscopy for biophysical applications : using plasmonic nanoparticle assemblies, Claudia Fasolato

Surface enhanced raman spectroscopy for biophysical applications : using plasmonic nanoparticle assemblies, Claudia Fasolato

Label
Surface enhanced raman spectroscopy for biophysical applications : using plasmonic nanoparticle assemblies
Title
Surface enhanced raman spectroscopy for biophysical applications
Title remainder
using plasmonic nanoparticle assemblies
Statement of responsibility
Claudia Fasolato
Creator
Author
Subject
Language
eng
Summary
The book explores the phenomenon of surface-enhanced Raman scattering (SERS), the huge amplification of Raman signal from molecules in the proximity of a metallic nanostructured surface, allowing readers to gain an in-depth understanding of the mechanisms affecting the spectroscopic response of SERS-active systems for effective applications. SERS spectroscopy is an ultrasensitive analytical technique with great potential for applications in the field of biophysics and nanomedicine. As examples, the author presents the design of nanocolloid-based SERS-active substrates for molecular sensing and of a folate-based SERS-active nanosensor capable of selectively interacting with cancer cells, enabling cancer diagnostics and therapy at the single-cell level. The author also suggests novel paths for the systematization of the SERS nanosystem design and experimental protocols to maximize sensitivity and reproducibility, which is essential when real-world biomedical applications are the goal of the study. With a combined approach, both fundamental and applied, and a detailed analysis of the state of the art, this book provides a valuable overview both for students new to SERS spectroscopy and for experts in the field
Member of
Cataloging source
GW5XE
http://library.link/vocab/creatorName
Fasolato, Claudia
Dewey number
535.8/46
Illustrations
illustrations
Index
no index present
LC call number
QC454.R36
Literary form
non fiction
Nature of contents
dictionaries
Series statement
Springer theses,
http://library.link/vocab/subjectName
  • Raman spectroscopy
  • Raman effect, Surface enhanced
  • Spectroscopy and Microscopy.
  • Biological and Medical Physics, Biophysics.
  • Surface and Interface Science, Thin Films.
Label
Surface enhanced raman spectroscopy for biophysical applications : using plasmonic nanoparticle assemblies, Claudia Fasolato
Instantiates
Publication
Note
"Doctoral thesis accepted by the Sapienze University of Rome, Rome, Italy."
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Intro; Supervisor's Foreword; Abstract; Parts of this thesis have been published in the following articles; Acknowledgements; Contents; 1 Introduction; References; 2 Traditional Raman and SERS: Fundamentals and State of the Art; 2.1 Optical Vibrational Spectroscopy of Molecules; 2.1.1 Theory of Raman Scattering; 2.2 Surface Enhanced Raman Scattering; 2.2.1 Electromagnetic Mechanism; 2.2.2 Chemical Mechanism; 2.3 Current Trends in Surface Enhanced Raman Scattering; 2.3.1 Nanoparticle-Based SERS Substrates; 2.3.2 SERS Applications in Nanomedicine
  • 2.3.3 Non Metallic Substrates: SERS from Semiconductor NanostructuresReferences; 3 Investigation on Nanoparticles and Their Molecular Functionalization; 3.1 Model Functionalization with 4ATP Linker; 3.1.1 Preparation and Control Characterization; 3.1.2 SERS Versus Raman Spectrum; 3.2 Further Conjugation: Folate and Antifolates; 3.2.1 Nanovector Functionalization: The Case of Folate; 3.2.2 SERS Signature of Folate/Antifolate Nanovectors; 3.3 Experimental Details; References; 4 Nanoparticle-Based SERS Substrates for Molecular Sensing Applications
  • 4.1 Self-assembled Mesoscopic Silver Nanoparticle Clusters4.1.1 Coupled AFM and Raman Analysis; 4.1.2 Dimensional Scale Effect on SERS Efficiency; 4.2 FDTD Simulation: Theoretical Predictions; 4.2.1 The FDTD Software; 4.2.2 Results on Silver and Gold Np Multilayers; 4.3 Electron Beam Lithography Driven Self-assembly; 4.3.1 Nanoparticle Cluster Array Preparation; 4.3.2 Analysis of the Patterned Arrays; 4.3.3 Analysis of the Ordered Nanoparticle Cluster Arrays; 4.3.4 SERS Reproducibility; References; 5 SERS-Active Nanovectors for Single-Cell Cancer Screening and Theranostics
  • 5.1 Early Cancer Diagnostics and Theranostics5.2 Folate-Based SERS Diagnostics; 5.2.1 Idea of the Experiment; 5.2.2 Cell Treatment and Viability Tests; 5.2.3 Raman and SERS Imaging on Treated Cells; 5.2.4 SEM Imaging on Treated Cells; 5.2.5 SERS Screening and Results; 5.3 From Selectivity to Theranostics: Antifolate Nanovectors; 5.3.1 Preliminary Cytotoxicity Results; 5.3.2 Enhanced Toxicity of Nanostructured Drugs; References; 6 Conclusions; A SERS Application in Cultural Heritage; A.1 HPTLC-SERS Investigation of Madder Lake Ammonia Extract; A.1.1 HPTLC-SERS Analytical Method
  • A.1.2 Experimental ResultsA.2 A Multianalytical Study Unravels Purple Dyeing Processes: The Case of a Historical Dress from the 19th Century; A.2.1 Introduction; A.2.2 Sicilian Noblewoman Dress: Microscopy, Sampling, Experimental Details; A.2.3 Results and Discussion; A.2.4 Conclusions; Curriculum Vitae
Dimensions
unknown
Extent
1 online resource (xviii, 155 pages)
File format
unknown
Form of item
online
Isbn
9783030035563
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-030-03556-3
Other physical details
illustrations (some color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • on1078921754
  • (OCoLC)1078921754
Label
Surface enhanced raman spectroscopy for biophysical applications : using plasmonic nanoparticle assemblies, Claudia Fasolato
Publication
Note
"Doctoral thesis accepted by the Sapienze University of Rome, Rome, Italy."
Antecedent source
unknown
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Intro; Supervisor's Foreword; Abstract; Parts of this thesis have been published in the following articles; Acknowledgements; Contents; 1 Introduction; References; 2 Traditional Raman and SERS: Fundamentals and State of the Art; 2.1 Optical Vibrational Spectroscopy of Molecules; 2.1.1 Theory of Raman Scattering; 2.2 Surface Enhanced Raman Scattering; 2.2.1 Electromagnetic Mechanism; 2.2.2 Chemical Mechanism; 2.3 Current Trends in Surface Enhanced Raman Scattering; 2.3.1 Nanoparticle-Based SERS Substrates; 2.3.2 SERS Applications in Nanomedicine
  • 2.3.3 Non Metallic Substrates: SERS from Semiconductor NanostructuresReferences; 3 Investigation on Nanoparticles and Their Molecular Functionalization; 3.1 Model Functionalization with 4ATP Linker; 3.1.1 Preparation and Control Characterization; 3.1.2 SERS Versus Raman Spectrum; 3.2 Further Conjugation: Folate and Antifolates; 3.2.1 Nanovector Functionalization: The Case of Folate; 3.2.2 SERS Signature of Folate/Antifolate Nanovectors; 3.3 Experimental Details; References; 4 Nanoparticle-Based SERS Substrates for Molecular Sensing Applications
  • 4.1 Self-assembled Mesoscopic Silver Nanoparticle Clusters4.1.1 Coupled AFM and Raman Analysis; 4.1.2 Dimensional Scale Effect on SERS Efficiency; 4.2 FDTD Simulation: Theoretical Predictions; 4.2.1 The FDTD Software; 4.2.2 Results on Silver and Gold Np Multilayers; 4.3 Electron Beam Lithography Driven Self-assembly; 4.3.1 Nanoparticle Cluster Array Preparation; 4.3.2 Analysis of the Patterned Arrays; 4.3.3 Analysis of the Ordered Nanoparticle Cluster Arrays; 4.3.4 SERS Reproducibility; References; 5 SERS-Active Nanovectors for Single-Cell Cancer Screening and Theranostics
  • 5.1 Early Cancer Diagnostics and Theranostics5.2 Folate-Based SERS Diagnostics; 5.2.1 Idea of the Experiment; 5.2.2 Cell Treatment and Viability Tests; 5.2.3 Raman and SERS Imaging on Treated Cells; 5.2.4 SEM Imaging on Treated Cells; 5.2.5 SERS Screening and Results; 5.3 From Selectivity to Theranostics: Antifolate Nanovectors; 5.3.1 Preliminary Cytotoxicity Results; 5.3.2 Enhanced Toxicity of Nanostructured Drugs; References; 6 Conclusions; A SERS Application in Cultural Heritage; A.1 HPTLC-SERS Investigation of Madder Lake Ammonia Extract; A.1.1 HPTLC-SERS Analytical Method
  • A.1.2 Experimental ResultsA.2 A Multianalytical Study Unravels Purple Dyeing Processes: The Case of a Historical Dress from the 19th Century; A.2.1 Introduction; A.2.2 Sicilian Noblewoman Dress: Microscopy, Sampling, Experimental Details; A.2.3 Results and Discussion; A.2.4 Conclusions; Curriculum Vitae
Dimensions
unknown
Extent
1 online resource (xviii, 155 pages)
File format
unknown
Form of item
online
Isbn
9783030035563
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.1007/978-3-030-03556-3
Other physical details
illustrations (some color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • on1078921754
  • (OCoLC)1078921754

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