Coverart for item
The Resource The endothelium, part I, multiple functions of the endothelial cells : focus on endothelium-derived vasoactive mediators, Michel Félétou, (electronic book)

The endothelium, part I, multiple functions of the endothelial cells : focus on endothelium-derived vasoactive mediators, Michel Félétou, (electronic book)

Label
The endothelium, part I, multiple functions of the endothelial cells : focus on endothelium-derived vasoactive mediators
Title
The endothelium
Title number
part I
Title part
multiple functions of the endothelial cells : focus on endothelium-derived vasoactive mediators
Statement of responsibility
Michel Félétou
Creator
Subject
Language
eng
Summary
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation
Member of
Cataloging source
CaBNVSL
http://library.link/vocab/creatorDate
1956-
http://library.link/vocab/creatorName
Félétou, Michel
Dewey number
612.13
Illustrations
illustrations
Index
no index present
LC call number
QP88.45
LC item number
.F454 2011 Part I
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
Series statement
Colloquium series on integrated systems physiology, from molecule to function
Series volume
19
http://library.link/vocab/subjectName
Endothelium
Target audience
specialized
Label
The endothelium, part I, multiple functions of the endothelial cells : focus on endothelium-derived vasoactive mediators, Michel Félétou, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 139-291)
Color
multicolored
Contents
  • 1. Introduction --
  • 2. Multiple functions of the endothelial cells -- 2.1 Heterogeneity of the endothelial cells -- 2.2 Hemostasis, thrombosis and fibrinolysis -- 2.3 Vascular permeability -- 2.4 Leukocyte trafficking -- 2.5 Vasculogenesis, angiogenesis and arteriogenesis -- 2.6 Metabolism and catabolism --
  • 3. Calcium signaling in vascular cells and cell-to-cell communications -- 3.1 Regulation of membrane potential and intracellular calcium concentration -- 3.2 Calcium signaling -- 3.3 Cell-to-cell communication and vascular function --
  • 4. Endothelium-dependent regulation of vascular tone -- 4.1 Nitric oxide synthases -- 4.2 Other gaseous mediators -- 4.3 Metabolism of arachidonic acid -- 4.4 Endocannabinoids and other lipid mediators -- 4.5 Other endothelium-derived vasoactive substances --
  • Conclusion -- References -- Author biography
Control code
201105ISP019
Dimensions
unknown
Extent
1 electronic text (xi, 293 p.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615041244
Other physical details
ill., digital file
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
The endothelium, part I, multiple functions of the endothelial cells : focus on endothelium-derived vasoactive mediators, Michel Félétou, (electronic book)
Publication
Bibliography note
Includes bibliographical references (p. 139-291)
Color
multicolored
Contents
  • 1. Introduction --
  • 2. Multiple functions of the endothelial cells -- 2.1 Heterogeneity of the endothelial cells -- 2.2 Hemostasis, thrombosis and fibrinolysis -- 2.3 Vascular permeability -- 2.4 Leukocyte trafficking -- 2.5 Vasculogenesis, angiogenesis and arteriogenesis -- 2.6 Metabolism and catabolism --
  • 3. Calcium signaling in vascular cells and cell-to-cell communications -- 3.1 Regulation of membrane potential and intracellular calcium concentration -- 3.2 Calcium signaling -- 3.3 Cell-to-cell communication and vascular function --
  • 4. Endothelium-dependent regulation of vascular tone -- 4.1 Nitric oxide synthases -- 4.2 Other gaseous mediators -- 4.3 Metabolism of arachidonic acid -- 4.4 Endocannabinoids and other lipid mediators -- 4.5 Other endothelium-derived vasoactive substances --
  • Conclusion -- References -- Author biography
Control code
201105ISP019
Dimensions
unknown
Extent
1 electronic text (xi, 293 p.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615041244
Other physical details
ill., digital file
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

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