The Resource The epidermis and blistering disorders : pemphigus, Sergei A. Grando, (streaming video)

The epidermis and blistering disorders : pemphigus, Sergei A. Grando, (streaming video)

Label
The epidermis and blistering disorders : pemphigus
Title
The epidermis and blistering disorders
Title remainder
pemphigus
Statement of responsibility
Sergei A. Grando
Creator
Speaker
Subject
Language
eng
Member of
Characteristic
videorecording
http://library.link/vocab/creatorName
Grando, Sergei A.,
Series statement
Skin biology
http://library.link/vocab/subjectName
  • Pemphigus
  • Skin
Label
The epidermis and blistering disorders : pemphigus, Sergei A. Grando, (streaming video)
Instantiates
Publication
Color
multicolored
Configuration of playback channels
monaural
Contents
Contents: Pemphigus vulgaris (PV) -- PV is a life-long, life-threatening, IgG autoantibody-mediated blistering disease affecting oral/esophageal surfaces and/or skin. The fundamental myths hampered progress of pemphigus research toward development of a safe and efficient treatment. Elucidation of intimate mechanisms of keratinocyte detachment and death in pemphigus has challenged the monopathogenic explanation of disease focused of desmoglein autoimmunity. This chapter discusses recent advances of knowledge on PV, scrutinize old dogmas, resolve controversies and opens novel perspectives for treatment. PV is caused by a variety of autoantibodies that synergize with effectors of apoptotic and oncotic pathways, serine proteases, and inflammatory cytokines to overcome the natural resistance and activate the cell death program in keratinocytes. The concept of apoptolysis distinguishes the unique mechanism of autoantibody-induced keratinocyte damage in PV from other known forms of cell death. Although the optimal therapeutic strategy has not been established, the natural course of PV has improved due to a substantial progress in developing of the steroid-sparing therapies combining the immunosuppressive and direct anti-acantholytic effects. The ultimate goal pemphigus research -- Cure of patients by safe, non-toxic therapy -- Can be achieved through further elucidation of the molecular mechanisms mediating PV IgG-dependent keratinocyte detachment
Control code
HST3597
Dimensions
unknown
Extent
1 online resource (1 streaming video file (57 min.)
File format
one file format
Form of item
electronic
Medium for sound
other
Other physical details
color, sound).
Publisher number
3597
Sound
sound
Sound on medium or separate
sound on medium
Specific material designation
  • remote
  • other
System details
System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v2.1+, iPhone 4+ (iOS v5.x+), iPad 2+ (iOS v5.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
Video recording format
other
Label
The epidermis and blistering disorders : pemphigus, Sergei A. Grando, (streaming video)
Publication
Color
multicolored
Configuration of playback channels
monaural
Contents
Contents: Pemphigus vulgaris (PV) -- PV is a life-long, life-threatening, IgG autoantibody-mediated blistering disease affecting oral/esophageal surfaces and/or skin. The fundamental myths hampered progress of pemphigus research toward development of a safe and efficient treatment. Elucidation of intimate mechanisms of keratinocyte detachment and death in pemphigus has challenged the monopathogenic explanation of disease focused of desmoglein autoimmunity. This chapter discusses recent advances of knowledge on PV, scrutinize old dogmas, resolve controversies and opens novel perspectives for treatment. PV is caused by a variety of autoantibodies that synergize with effectors of apoptotic and oncotic pathways, serine proteases, and inflammatory cytokines to overcome the natural resistance and activate the cell death program in keratinocytes. The concept of apoptolysis distinguishes the unique mechanism of autoantibody-induced keratinocyte damage in PV from other known forms of cell death. Although the optimal therapeutic strategy has not been established, the natural course of PV has improved due to a substantial progress in developing of the steroid-sparing therapies combining the immunosuppressive and direct anti-acantholytic effects. The ultimate goal pemphigus research -- Cure of patients by safe, non-toxic therapy -- Can be achieved through further elucidation of the molecular mechanisms mediating PV IgG-dependent keratinocyte detachment
Control code
HST3597
Dimensions
unknown
Extent
1 online resource (1 streaming video file (57 min.)
File format
one file format
Form of item
electronic
Medium for sound
other
Other physical details
color, sound).
Publisher number
3597
Sound
sound
Sound on medium or separate
sound on medium
Specific material designation
  • remote
  • other
System details
System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v2.1+, iPhone 4+ (iOS v5.x+), iPad 2+ (iOS v5.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
Video recording format
other

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