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The Resource The p53 tumor suppressor pathway and cancer, edited by Gerard P. Zambetti, (electronic book)

The p53 tumor suppressor pathway and cancer, edited by Gerard P. Zambetti, (electronic book)

Label
The p53 tumor suppressor pathway and cancer
Title
The p53 tumor suppressor pathway and cancer
Statement of responsibility
edited by Gerard P. Zambetti
Contributor
Subject
Language
eng
Summary
The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging?eld?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signi?cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53?eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the?eld exploded and p53 became a major focus of scientists around the world
Member of
Cataloging source
COO
Dewey number
616.99/4042
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Zambetti, Gerard P.
http://library.link/vocab/subjectName
  • p53 antioncogene
  • p53 protein
  • Tumor Suppressor Protein p53
  • Neoplasms
Label
The p53 tumor suppressor pathway and cancer, edited by Gerard P. Zambetti, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
SPR173769999
Extent
x, 246 p.
Form of item
online
Isbn
9780387301273
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
ill. (some col.).
Specific material designation
remote
Label
The p53 tumor suppressor pathway and cancer, edited by Gerard P. Zambetti, (electronic book)
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
SPR173769999
Extent
x, 246 p.
Form of item
online
Isbn
9780387301273
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
ill. (some col.).
Specific material designation
remote

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