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The Resource The role of proprotein convertases in animal models of skin carcinogenesis, Daniel Bassi ... [et al.], (electronic book)

The role of proprotein convertases in animal models of skin carcinogenesis, Daniel Bassi ... [et al.], (electronic book)

Label
The role of proprotein convertases in animal models of skin carcinogenesis
Title
The role of proprotein convertases in animal models of skin carcinogenesis
Statement of responsibility
Daniel Bassi ... [et al.]
Contributor
Subject
Language
eng
Summary
Many proprotein convertases (PC), especially furin and PACE4, are involved in pathological processes such as viral infection, inflammation, hypercholesterolemia, and cancer, and have been postulated as therapeutic targets for some of these diseases. In this chapter, we review mostly our work using animal models of squamous cancers that have been induced by chemical or UV carcinogenesis protocols to highlight the role of PCs in the development and progression of experimental tumors. After demonstrating in wild type mice the role of PACE4 in tumor progression as well as detecting the expression of PACE4 and furin in human non-melanoma skin cancers, we developed transgenic mice that over-express either PACE4 or furin in squamous epithelia, including the epidermis. This was accomplished by targeting the expression of the corresponding PC by using the promoter of the bovine keratin 5. Both K5-PACE4 and K5-Furin transgenic mice showed increased susceptibility to a two-stage carcinogenesis protocol of chemical carcinogenesis. Similar studies conducted in K5-PACE4 mice also showed an increased sensitivity to ultraviolet B radiation carcinogenesis. In most of these experiments, we were able to demonstrate that compared to the control wild type mice, the over-expression of the transgene in the epidermis increased the number of benign and malignant skin tumors and also had an effect on tumor progression as evidenced by the presence of less differentiated tumors and more frequent local and distant metastases in many of the transgenic lines. Interestingly, double transgenic mice in which PACE4 and furin are targeted to the epidermis did not show any additive effect, pointing to a probable in vivo overlap of functions at least in cutaneous tissues. The tumor-enhancing effects of PACE4 and furin further support their possible role as therapeutic targets. Furthermore, a proof of principle for PC inhibition as a therapeutic tool has been substantiated by an in vivo experiment in which the PC-inhibitor, decanoyl-RVKR-chloromethylketone, was topically administrated to the skin of wild type and transgenic mice treated with chemical carcinogenesis protocols, resulting in a significant decrease of tumor development and progression
Member of
Cataloging source
CaBNVSL
Dewey number
616.99477
Illustrations
illustrations
Index
no index present
LC call number
RC280.S5
LC item number
R656 2012
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Bassi, Daniel
http://library.link/vocab/subjectName
  • Protein precursors
  • Squamous cell carcinoma
  • Enzyme inhibitors
  • Proprotein Convertases
  • Carcinoma, Squamous Cell
  • Enzyme Inhibitors
Target audience
  • adult
  • specialized
Label
The role of proprotein convertases in animal models of skin carcinogenesis, Daniel Bassi ... [et al.], (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 35-40)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • 1. Introduction -- 1.1 Skin cancer --
  • 2. Proprotein convertases in skin -- 2.1 Expression of proprotein convertases in human skin and cutaneous tumors -- 2.2 Expression of proprotein convertases in murine skin and skin tumors --
  • 3. Animal models of non-melanoma skin carcinogenesis -- 3.1 Proprotein convertases in experimental skin cancer --
  • 4. Transgenic models of proprotein convertase-mediated skin carcinogenesis -- 4.1 K5-PACE4 transgenic mice -- 4.1.1 Chemical carcinogenesis -- 4.1.2 Ultraviolet carcinogenesis -- 4.2 K5-furin transgenic mice -- 4.2.1 Chemical carcinogenesis -- 4.3 Double transgenic mice -- 4.3.1 Chemical carcinogenesis --
  • 5. In vivo inhibition of proprotein convertases --
  • 6. Conclusions -- References -- Author biography -- Titles of related interest
Control code
201206PAC001
Dimensions
unknown
Extent
1 electronic text (xi, 45 p.)
File format
multiple file formats
Form of item
online
Isbn
9781615045099
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.4199/C00060ED1V01Y201206PAC001
Other physical details
ill., digital file.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
The role of proprotein convertases in animal models of skin carcinogenesis, Daniel Bassi ... [et al.], (electronic book)
Publication
Bibliography note
Includes bibliographical references (p. 35-40)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • 1. Introduction -- 1.1 Skin cancer --
  • 2. Proprotein convertases in skin -- 2.1 Expression of proprotein convertases in human skin and cutaneous tumors -- 2.2 Expression of proprotein convertases in murine skin and skin tumors --
  • 3. Animal models of non-melanoma skin carcinogenesis -- 3.1 Proprotein convertases in experimental skin cancer --
  • 4. Transgenic models of proprotein convertase-mediated skin carcinogenesis -- 4.1 K5-PACE4 transgenic mice -- 4.1.1 Chemical carcinogenesis -- 4.1.2 Ultraviolet carcinogenesis -- 4.2 K5-furin transgenic mice -- 4.2.1 Chemical carcinogenesis -- 4.3 Double transgenic mice -- 4.3.1 Chemical carcinogenesis --
  • 5. In vivo inhibition of proprotein convertases --
  • 6. Conclusions -- References -- Author biography -- Titles of related interest
Control code
201206PAC001
Dimensions
unknown
Extent
1 electronic text (xi, 45 p.)
File format
multiple file formats
Form of item
online
Isbn
9781615045099
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other control number
10.4199/C00060ED1V01Y201206PAC001
Other physical details
ill., digital file.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

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