Coverart for item
The Resource Transcriptional control of neural crest development, Brian L. Nelms and Patricia A. Labosky, (electronic book)

Transcriptional control of neural crest development, Brian L. Nelms and Patricia A. Labosky, (electronic book)

Label
Transcriptional control of neural crest development
Title
Transcriptional control of neural crest development
Statement of responsibility
Brian L. Nelms and Patricia A. Labosky
Creator
Contributor
Author
Subject
Language
eng
Summary
The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecified, nonmigratory population to a wide array of dynamic, differentiated cell types--some of which retain stem cell characteristics presumably to replenish these derivatives-- requires a complex network of molecular switches to control the gene programs giving these cells their defining structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specific transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state
Member of
Cataloging source
CaBNvSL
http://library.link/vocab/creatorName
Nelms, Brian L
Dewey number
573.86387
Illustrations
illustrations
Index
no index present
LC call number
QL938.N48
LC item number
N457 2010
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Labosky, Patricia A.
Series statement
Colloquium series on developmental biology
Series volume
1
http://library.link/vocab/subjectName
  • Neural crest
  • Transcription factors
  • Developmental neurobiology
  • Neural Crest
Target audience
specialized
Label
Transcriptional control of neural crest development, Brian L. Nelms and Patricia A. Labosky, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 159-226e)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • 1. Introduction -- The role of transcriptional regulation in development -- Neural crest cells have remarkable developmental plasticity -- The role of transcription factors in neural crest stem cells and induced pluripotent stem cells -- NC misregulation in disease states -- Reviewing current knowledge of NC transcriptional control --
  • 2. AP genes -- AP-1 -- AP-2a (Tcfap2a) -- Mouse AP-2a -- Chicken AP-2a -- Zebrafish AP-2a mutants -- Xenopus AP2a -- Regulation of AP-2 -- AP-2 targets -- AP-2 binding sites -- AP-2 as an NC marker -- AP-2B (Tcfap2b) -- AP-2y (Tcfap2c) -- AP-2d (Tcfap2d) and AP-2e (Tcfap2e) --
  • 3. bHLH genes -- Ascl1 -- Ascl1 in the sympathoadrenal lineage -- Regulation of Ascl1 by BMP, cAMP, and notch signaling -- Ascl1 interaction with other transcription factors and targets -- Ascl1 in human disease -- Hand1 -- Hand2 -- Hand2 in the Pharyngeal Arches and Derivatives -- Hand2 in the Heart -- Hand2 in the Sympathetic Nervous System -- Hand2 in the Enteric Nervous System -- Hand2 in Neuroblastoma -- Hand2 Partners and Function -- Mitf -- Targets of Mitf -- Regulation of Mitf by Sox10 and Pax3 -- Regulation of Zebrafish Mitf by Foxd3 -- Mitf Downstream of Wnt Signaling -- Posttranslational Regulation of Mitf -- Mitf in Human Disease -- Myc -- Mycn -- Tcf3, Tcf4, and Tcf12 (E Proteins) -- Twist1 -- Twist1 in the Cranial Mesenchyme and Pharyngeal Arches -- Twist1 in the Skull Vault -- Twist in Zebrafish and Xenopus -- Twist as an NC Marker and in Cancer and NC-Derived Stem Cells -- Other Basic Helix-Loop-Helix Genes: Usf1, Usf 2, Tcfe3, Mnt, Olig3 --
  • 4. ETS Genes -- Ets1 and Ets2 -- Elk1 and Elk4 -- Etv1, Etv4, and Etv5 -- Erg -- Fli1 -- Ets Translocations --
  • 5. Fox Genes -- FoxC -- FoxD -- Foxd3 in Neural Crest Progenitor Cells -- NC Induction and Regulation of Foxd3 -- Foxd3 Suppresses the Melanocyte Lineage -- FoxE -- FoxF -- FoxJ -- FoxN -- FoxO -- FoxS --
  • 6. Homeobox Genes -- Alx -- Barx1 -- Dlx1, Dlx2, Dlx3, Dlx5, Dlx6 -- Dlx1 and Dlx2 -- Dlx3 -- Dlx4 -- Dlx5 -- Dlx6 -- Emx -- Gsx -- Hlx -- Hmx1 -- Irx -- LBX1 and Lbx2 -- Msx1 and Msx2 -- Pitx2 -- Prrx1 and Prrx2 -- Runx1 and Runx2 -- Tlx --
  • 7. Hox Genes -- Anterior Hox Genes (Hox1, Hox2, and Hox3 Paralogous Groups) -- Hoxa1, Hoxb1, and Hoxd1 -- Hoxa2 and Hoxb2 -- Hoxa3, Hoxb3, and Hoxd3 -- Hox4 and Hox5 Paralogous Groups -- Posterior Hox Genes (Hox6, Hox7, Hox8, and Hox9 Paralogous Groups) --
  • 8. Lim Genes -- Lhx1 and Lhx7 -- Lims1, Jub, Pdlim5, Lmo4 --
  • 9. Pax Genes -- Pax3 -- Pax3 in Early Neural Crest Development and Migration -- Pax3 in Neural and Glial Lineages -- Pax3 in the Cardiac Neural Crest -- Pax3 in the Melanocyte Lineage -- Pax3 in Waardenburg Syndrome, Tumors and other Neurocristopathies -- Pax3 Regulation and Interaction with Other Genes -- Pax6 -- Pax7 -- Pax9 --
  • 10. POU Domain Genes -- Pou2f1/Oct1 -- Pou3f1/Oct6 -- Pou3f2/Brn2/Oct5 -- Pou4f1/Brn3 -- Pou5f1/Oct4 --
  • 11. RAR/RXR Genes -- RARa, RARb, and RARg -- RXRa, RXRb, and RXRg --
  • 12. Smad Genes -- Early NC -- Cardiac NC -- Neural, Glial, and Sympathoadrenal NC -- Ocular NC -- Dental NC --
  • 13. Sox Genes -- Sox2 -- Sox4 -- Sox5 -- Sox8 -- Sox9 -- Sox9 during Neural Crest Specification -- The Role of Sox9 in Chondrogenesis -- Sox9 in NCSCs -- Sox9 in the Melanocyte Lineage -- Sox10 -- Sox10 Expression during NC Induction and in Migratory NCCs -- Transcription Factors Upstream of Sox10 in NC Development -- Regulation of Sox10 -- Sox10 Mutants as a Model for Waardenburg Syndrome 4 -- Sox10 in Glia of the PNS -- Sox10 in Neural Derivatives -- Sox10 in Melanocytes and Regulation of Mitf -- Coregulation of Mitf Target Genes by Sox10 -- Additional Sox10 Regulation -- Sox10 in Melanocyte Stem Cells -- Sox10 in NCSCs and Cancer --
  • 14. Zinc Finger Genes -- Gata2/3 -- Gata4 -- Gata6 -- Krox20 -- Krox20 in Schwann Cells -- Krox20 in Patterning -- Mecom/Evi1 -- Nczf -- Prdm1 and Prdm2 -- Snail -- Xenopus Snail -- Zebrafish Snail -- Chicken Snail -- Mouse Snail -- Human Snail -- Slug -- Avian Slug -- Xenopus Slug and Upstream Regulation -- Downstream of Xenopus Slug -- Mouse Slug -- Slug in Humans -- Snail and Slug in Stem Cell Culture -- Zeb1 and Zeb2 -- Zfp704 -- Zic1 -- Zic2 -- Zic3 -- Zic4 and Zic5 --
  • 15. Other Miscellaneous Genes -- Atf1 -- Cited2 and Cited4 -- Creb1 -- Ctbp1 and Ctbp2 -- Dawg -- Mafb -- Mediator Subunits Med12 and Med24 -- Mef2 -- Mrf2-- Myb and Mybl2 -- Myocd, Mkl1, Mkl2 -- Nfatc3 and Nfatc4 -- Nfyb -- Nuclear Receptors Nr2f1, Nr2f2, Nr5a1, Nr5a2 -- Rela (NFkB Subunit) -- Srf -- Immediate-Early Genes Sp1, Sp3, and Sp4 -- Stat3 -- Tcof1 -- Tead2 -- Tsc22d1 -- References -- Author Biographies
Dimensions
unknown
Extent
1 electronic text (xii, 227 p. : ill.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615040490
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
digital file
Reformatting quality
access
Specific material designation
remote
Label
Transcriptional control of neural crest development, Brian L. Nelms and Patricia A. Labosky, (electronic book)
Publication
Bibliography note
Includes bibliographical references (p. 159-226e)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • 1. Introduction -- The role of transcriptional regulation in development -- Neural crest cells have remarkable developmental plasticity -- The role of transcription factors in neural crest stem cells and induced pluripotent stem cells -- NC misregulation in disease states -- Reviewing current knowledge of NC transcriptional control --
  • 2. AP genes -- AP-1 -- AP-2a (Tcfap2a) -- Mouse AP-2a -- Chicken AP-2a -- Zebrafish AP-2a mutants -- Xenopus AP2a -- Regulation of AP-2 -- AP-2 targets -- AP-2 binding sites -- AP-2 as an NC marker -- AP-2B (Tcfap2b) -- AP-2y (Tcfap2c) -- AP-2d (Tcfap2d) and AP-2e (Tcfap2e) --
  • 3. bHLH genes -- Ascl1 -- Ascl1 in the sympathoadrenal lineage -- Regulation of Ascl1 by BMP, cAMP, and notch signaling -- Ascl1 interaction with other transcription factors and targets -- Ascl1 in human disease -- Hand1 -- Hand2 -- Hand2 in the Pharyngeal Arches and Derivatives -- Hand2 in the Heart -- Hand2 in the Sympathetic Nervous System -- Hand2 in the Enteric Nervous System -- Hand2 in Neuroblastoma -- Hand2 Partners and Function -- Mitf -- Targets of Mitf -- Regulation of Mitf by Sox10 and Pax3 -- Regulation of Zebrafish Mitf by Foxd3 -- Mitf Downstream of Wnt Signaling -- Posttranslational Regulation of Mitf -- Mitf in Human Disease -- Myc -- Mycn -- Tcf3, Tcf4, and Tcf12 (E Proteins) -- Twist1 -- Twist1 in the Cranial Mesenchyme and Pharyngeal Arches -- Twist1 in the Skull Vault -- Twist in Zebrafish and Xenopus -- Twist as an NC Marker and in Cancer and NC-Derived Stem Cells -- Other Basic Helix-Loop-Helix Genes: Usf1, Usf 2, Tcfe3, Mnt, Olig3 --
  • 4. ETS Genes -- Ets1 and Ets2 -- Elk1 and Elk4 -- Etv1, Etv4, and Etv5 -- Erg -- Fli1 -- Ets Translocations --
  • 5. Fox Genes -- FoxC -- FoxD -- Foxd3 in Neural Crest Progenitor Cells -- NC Induction and Regulation of Foxd3 -- Foxd3 Suppresses the Melanocyte Lineage -- FoxE -- FoxF -- FoxJ -- FoxN -- FoxO -- FoxS --
  • 6. Homeobox Genes -- Alx -- Barx1 -- Dlx1, Dlx2, Dlx3, Dlx5, Dlx6 -- Dlx1 and Dlx2 -- Dlx3 -- Dlx4 -- Dlx5 -- Dlx6 -- Emx -- Gsx -- Hlx -- Hmx1 -- Irx -- LBX1 and Lbx2 -- Msx1 and Msx2 -- Pitx2 -- Prrx1 and Prrx2 -- Runx1 and Runx2 -- Tlx --
  • 7. Hox Genes -- Anterior Hox Genes (Hox1, Hox2, and Hox3 Paralogous Groups) -- Hoxa1, Hoxb1, and Hoxd1 -- Hoxa2 and Hoxb2 -- Hoxa3, Hoxb3, and Hoxd3 -- Hox4 and Hox5 Paralogous Groups -- Posterior Hox Genes (Hox6, Hox7, Hox8, and Hox9 Paralogous Groups) --
  • 8. Lim Genes -- Lhx1 and Lhx7 -- Lims1, Jub, Pdlim5, Lmo4 --
  • 9. Pax Genes -- Pax3 -- Pax3 in Early Neural Crest Development and Migration -- Pax3 in Neural and Glial Lineages -- Pax3 in the Cardiac Neural Crest -- Pax3 in the Melanocyte Lineage -- Pax3 in Waardenburg Syndrome, Tumors and other Neurocristopathies -- Pax3 Regulation and Interaction with Other Genes -- Pax6 -- Pax7 -- Pax9 --
  • 10. POU Domain Genes -- Pou2f1/Oct1 -- Pou3f1/Oct6 -- Pou3f2/Brn2/Oct5 -- Pou4f1/Brn3 -- Pou5f1/Oct4 --
  • 11. RAR/RXR Genes -- RARa, RARb, and RARg -- RXRa, RXRb, and RXRg --
  • 12. Smad Genes -- Early NC -- Cardiac NC -- Neural, Glial, and Sympathoadrenal NC -- Ocular NC -- Dental NC --
  • 13. Sox Genes -- Sox2 -- Sox4 -- Sox5 -- Sox8 -- Sox9 -- Sox9 during Neural Crest Specification -- The Role of Sox9 in Chondrogenesis -- Sox9 in NCSCs -- Sox9 in the Melanocyte Lineage -- Sox10 -- Sox10 Expression during NC Induction and in Migratory NCCs -- Transcription Factors Upstream of Sox10 in NC Development -- Regulation of Sox10 -- Sox10 Mutants as a Model for Waardenburg Syndrome 4 -- Sox10 in Glia of the PNS -- Sox10 in Neural Derivatives -- Sox10 in Melanocytes and Regulation of Mitf -- Coregulation of Mitf Target Genes by Sox10 -- Additional Sox10 Regulation -- Sox10 in Melanocyte Stem Cells -- Sox10 in NCSCs and Cancer --
  • 14. Zinc Finger Genes -- Gata2/3 -- Gata4 -- Gata6 -- Krox20 -- Krox20 in Schwann Cells -- Krox20 in Patterning -- Mecom/Evi1 -- Nczf -- Prdm1 and Prdm2 -- Snail -- Xenopus Snail -- Zebrafish Snail -- Chicken Snail -- Mouse Snail -- Human Snail -- Slug -- Avian Slug -- Xenopus Slug and Upstream Regulation -- Downstream of Xenopus Slug -- Mouse Slug -- Slug in Humans -- Snail and Slug in Stem Cell Culture -- Zeb1 and Zeb2 -- Zfp704 -- Zic1 -- Zic2 -- Zic3 -- Zic4 and Zic5 --
  • 15. Other Miscellaneous Genes -- Atf1 -- Cited2 and Cited4 -- Creb1 -- Ctbp1 and Ctbp2 -- Dawg -- Mafb -- Mediator Subunits Med12 and Med24 -- Mef2 -- Mrf2-- Myb and Mybl2 -- Myocd, Mkl1, Mkl2 -- Nfatc3 and Nfatc4 -- Nfyb -- Nuclear Receptors Nr2f1, Nr2f2, Nr5a1, Nr5a2 -- Rela (NFkB Subunit) -- Srf -- Immediate-Early Genes Sp1, Sp3, and Sp4 -- Stat3 -- Tcof1 -- Tead2 -- Tsc22d1 -- References -- Author Biographies
Dimensions
unknown
Extent
1 electronic text (xii, 227 p. : ill.)
File format
multiple file formats
Form of item
electronic
Isbn
9781615040490
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
digital file
Reformatting quality
access
Specific material designation
remote

Library Locations

Processing Feedback ...