Directed enzyme evolution : advances and applications

Resource Information

The work Directed enzyme evolution : advances and applications represents a distinct intellectual or artistic creation found in University of Liverpool. This resource is a combination of several types including: Work, Language Material, Books.

Label

Directed enzyme evolution : advances and applications

Title remainder

advances and applications

Statement of responsibility

Miguel Alcalde, editor

Contributor

• Alcalde, Miguel

Editor

• Alcalde, Miguel

Subject

• Enzymes -- Biotechnology
• Molecular evolution
• Protein engineering

Language

eng

Summary

This book focuses on some of the most significant advances in enzyme engineering that have been achieved through directed evolution and hybrid approaches. On the 25th anniversary of the discovery of directed evolution, this volume is a tribute to the pioneers of this thrilling research field, and at the same time provides a comprehensive overview of current research and the state of the art. Directed molecular evolution has become the most reliable and robust method to tailor enzymes, metabolic pathways or even whole microorganisms with improved traits. By mirroring the Darwinian algorithm of natural selection on a laboratory scale, new biomolecules of invaluable biotechnological interest can now be engineered in a manner that surpasses the boundaries of nature. The volume is divided into two sections, the first of which provides an update on recent successful cases of enzyme ensembles from different areas of the biotechnological spectrum, including tryptophan synthases, unspecific peroxygenases, phytases, therapeutic enzymes, stereoselective enzymes and CO2-fixing enzymes. This section also provides information on the directed evolution of whole cells. The second section of the book summarizes a variety of the most applicable methods for library creation, together with the future trends aimed at bringing together directed evolution and in silico/computational enzyme design and ancestral resurrection

Member of

• Online access with purchase: Springer

Cataloging source

N$T

Dewey number

660.6/34

Index

no index present

LC call number

QH442

Literary form

non fiction

Nature of contents

• dictionaries
• bibliography