Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection

The Resource Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection
Label
Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection
Title remainder
hormesis, preconditioning, and cardioprotection
Statement of responsibility
Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis
Creator
Contributor
Author
Subject
Language
eng
Summary
The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects of ischemia/reperfusion (I/R). We begin with a discussion of the concept of hormesis (a term used most extensively in the toxicologic literature which refers to biphasic cellular responses that depend on concentration or intensity of a stimulus), review the seminal studies that led to the discovery of the cardioprotective effects of ischemic preconditioning, and outline its therapeutic potential (Chapter 1). This is followed by a summary of our current understanding of the mechanisms of I/R injury (Chapter 2 ), as this provides several points of intervention in limiting postischemic tissue injury that may be targeted by the adaptive programs invoked by conditioning stimuli. Chapters 3 and 4 focus on the mechanisms underlying ischemic pre-, post-, and remote conditioning, which establishes the mechanistic rationale for development of pharmacologic conditioning strategies that may mimic the remarkably powerful effects of ischemic conditioning (and are covered in Chapter 5 ). Lifestyle interventions, including exercise, caloric restriction, and consumption of alcoholic beverages and/or phytochemicals, that may induce hormetic responses will also be reviewed in this chapter. While the promise for conditioning as a therapeutic approach is enormous, there are obstacles to its practical application in patients, which are covered in Chapter 6 . The final chapter (Chapter 7 ) examines the extension of our mechanistic understanding of the signaling pathways invoked by conditioning stimuli into the realm of gene therapy and to the preservation of stem cell viability in the harsh ischemic environment as natural translational outgrowths of preconditioning into therapeutics
Member of
Additional physical form
Also available in print.
Cataloging source
CaBNVSL
Dewey number
616.13
Illustrations
illustrations
Index
no index present
LC call number
RB144
LC item number
.K743 2013
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
Target audience
  • adult
  • specialized
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