Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection

The Resource Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection

Label

Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection

Title remainder

hormesis, preconditioning, and cardioprotection

Statement of responsibility

Maike Krenz, Christopher Baines, Theodore Kalogeris, and Ronald J. Korthuis

Language

eng

Summary

The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects of ischemia/reperfusion (I/R). We begin with a discussion of the concept of hormesis (a term used most extensively in the toxicologic literature which refers to biphasic cellular responses that depend on concentration or intensity of a stimulus), review the seminal studies that led to the discovery of the cardioprotective effects of ischemic preconditioning, and outline its therapeutic potential (Chapter 1). This is followed by a summary of our current understanding of the mechanisms of I/R injury (Chapter 2 ), as this provides several points of intervention in limiting postischemic tissue injury that may be targeted by the adaptive programs invoked by conditioning stimuli. Chapters 3 and 4 focus on the mechanisms underlying ischemic pre-, post-, and remote conditioning, which establishes the mechanistic rationale for development of pharmacologic conditioning strategies that may mimic the remarkably powerful effects of ischemic conditioning (and are covered in Chapter 5 ). Lifestyle interventions, including exercise, caloric restriction, and consumption of alcoholic beverages and/or phytochemicals, that may induce hormetic responses will also be reviewed in this chapter. While the promise for conditioning as a therapeutic approach is enormous, there are obstacles to its practical application in patients, which are covered in Chapter 6 . The final chapter (Chapter 7 ) examines the extension of our mechanistic understanding of the signaling pathways invoked by conditioning stimuli into the realm of gene therapy and to the preservation of stem cell viability in the harsh ischemic environment as natural translational outgrowths of preconditioning into therapeutics

Additional physical form

Also available in print.

Cataloging source

CaBNVSL

Dewey number

616.13

Illustrations

illustrations

Index

no index present

LC call number

RB144

LC item number

.K743 2013

Literary form

non fiction

Nature of contents

dictionaries
abstracts summaries
bibliography

Target audience

adult
specialized

Context

Context of Cell survival programs and ischemia/reperfusion : hormesis, preconditioning, and cardioprotection

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