Coverart for item
The Resource Crucial role for astrocytes in epilepsy, Peter Bedner and Christian Steinhäuser, (electronic book)

Crucial role for astrocytes in epilepsy, Peter Bedner and Christian Steinhäuser, (electronic book)

Label
Crucial role for astrocytes in epilepsy
Title
Crucial role for astrocytes in epilepsy
Statement of responsibility
Peter Bedner and Christian Steinhäuser
Creator
Contributor
Author
Subject
Language
eng
Summary
This book summarizes current evidence of astrocyte dysfunction in epilepsy and discusses presumed underlying mechanisms. Epilepsy is characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizures in about one third of patients. Thus, there is an urgent need for new therapies that prevent generation of the disorder and improve seizure control in individuals already afflicted. The vast majority of epileptic cases are of idiopathic origin with their underlying mechanisms being unclear. Neurosurgical specimens from patients presenting with mesial temporal lobe epilepsy (MTLE) demonstrate marked reactive gliosis. Since recent studies have implicated astrocytes in important physiological roles in the CNS, such as synchronization of neuronal firing, it is plausible that they may also have a role in seizure generation and/or seizure spread. In support of this view, various membrane channels, receptors, and transporters in astrocytic membranes are altered in the epileptic brain. Excitingly, recent evidence suggests that in the course of the pathogenesis of MTLE, these glial changes alter homeostatic network functions and temporally precede the alterations in neurons. These findings might eventually classify MTLE as a glial rather than a neuronal disorder, and identify astrocytes as promising new targets for the development of more specific antiepileptogenic therapeutic strategies. Although research on astrocytes in epilepsy is still in its infancy, this book clearly demonstrates a critical role of astrocytes in the disturbance of K+ and transmitter homeostasis and its impact on seizure generation
Member of
Cataloging source
CaBNVSL
http://library.link/vocab/creatorName
Bedner, Peter
Dewey number
616.853
Illustrations
illustrations
Index
no index present
LC call number
RC372
LC item number
.B433 2015
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Steinhäuser, Christian.
Series statement
Colloquium series on neuroglia in biology and medicine,
Series volume
8
http://library.link/vocab/subjectName
  • Epilepsy
  • Astrocytes
  • Epilepsy
  • Astrocytes
Target audience
  • adult
  • specialized
Label
Crucial role for astrocytes in epilepsy, Peter Bedner and Christian Steinhäuser, (electronic book)
Instantiates
Publication
Bibliography note
Includes bibliographical references (pages 47-77)
Carrier category
online resource
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type MARC source
rdacontent
Contents
  • 1. Introduction --
  • 2. K+ buffering in epilepsy -- 2.1 K+ uptake and spatial buffering -- 2.2 Kir4.1 channels and K+ buffering in epilepsy --
  • 3. GJ communication in epilepsy -- 3.1 GJ coupling of astrocytes -- 3.2 Potential roles of GJs in epilepsy -- 3.3 Connexin expression and coupling in epileptic tissue -- 3.4 Role of Cx hemichannels and pannexin channels in epilepsy --
  • 4. Aquaporin-4 dysfunction and epilepsy -- 4.1 Astrocytes express aquaporin-4 -- 4.2 Role of aquaporin-4 in epilepsy -- 4.3 AQP4 expression and regulation in epileptic tissue --
  • 5. Altered glutamate homeostasis in epilepsy -- 5.1 Astrocytes regulate the extracellular glutamate concentration -- 5.2 Extracellular glutamate levels and glutamate uptake in TLE -- 5.3 Regulation of GS in epilepsy --
  • 6. Dysfunction of the BBB in epilepsy -- 6.1 Consequences of BBB opening for neuronal and astrocytic function -- 6.2 TGF[beta] receptor signaling in astrocytes and epileptogenesis --
  • 7. Astrocyte Ca2+ signaling and gliotransmission in epilepsy -- 7.1 Ca2+ signaling -- 7.2 Glutamate release -- 7.3 Astrocyte release of ATP and epilepsy --
  • 8. Adenosine dysfunction in epilepsy -- 8.1 Role of astrocyte-derived adenosine in epilepsy -- 8.2 Role of glial ADK in epilepsy --
  • 9. Astrocyte immune responses and epilepsy -- 9.1 Astrocyte changes induced by brain inflammation -- 9.2 Involvement of astrocytes in brain inflammation --
  • 10. Astrocytes and absence epilepsy --
  • 11. Conclusions -- References -- Author biographies
Control code
201507NGL008
Dimensions
unknown
Extent
1 PDF (ix, 79 pages)
File format
multiple file formats
Form of item
online
Isbn
9781615047154
Media category
electronic
Media MARC source
isbdmedia
Other control number
10.4199/C00135ED1V01Y201507NGL008
Other physical details
illustrations.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader
Label
Crucial role for astrocytes in epilepsy, Peter Bedner and Christian Steinhäuser, (electronic book)
Publication
Bibliography note
Includes bibliographical references (pages 47-77)
Carrier category
online resource
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type MARC source
rdacontent
Contents
  • 1. Introduction --
  • 2. K+ buffering in epilepsy -- 2.1 K+ uptake and spatial buffering -- 2.2 Kir4.1 channels and K+ buffering in epilepsy --
  • 3. GJ communication in epilepsy -- 3.1 GJ coupling of astrocytes -- 3.2 Potential roles of GJs in epilepsy -- 3.3 Connexin expression and coupling in epileptic tissue -- 3.4 Role of Cx hemichannels and pannexin channels in epilepsy --
  • 4. Aquaporin-4 dysfunction and epilepsy -- 4.1 Astrocytes express aquaporin-4 -- 4.2 Role of aquaporin-4 in epilepsy -- 4.3 AQP4 expression and regulation in epileptic tissue --
  • 5. Altered glutamate homeostasis in epilepsy -- 5.1 Astrocytes regulate the extracellular glutamate concentration -- 5.2 Extracellular glutamate levels and glutamate uptake in TLE -- 5.3 Regulation of GS in epilepsy --
  • 6. Dysfunction of the BBB in epilepsy -- 6.1 Consequences of BBB opening for neuronal and astrocytic function -- 6.2 TGF[beta] receptor signaling in astrocytes and epileptogenesis --
  • 7. Astrocyte Ca2+ signaling and gliotransmission in epilepsy -- 7.1 Ca2+ signaling -- 7.2 Glutamate release -- 7.3 Astrocyte release of ATP and epilepsy --
  • 8. Adenosine dysfunction in epilepsy -- 8.1 Role of astrocyte-derived adenosine in epilepsy -- 8.2 Role of glial ADK in epilepsy --
  • 9. Astrocyte immune responses and epilepsy -- 9.1 Astrocyte changes induced by brain inflammation -- 9.2 Involvement of astrocytes in brain inflammation --
  • 10. Astrocytes and absence epilepsy --
  • 11. Conclusions -- References -- Author biographies
Control code
201507NGL008
Dimensions
unknown
Extent
1 PDF (ix, 79 pages)
File format
multiple file formats
Form of item
online
Isbn
9781615047154
Media category
electronic
Media MARC source
isbdmedia
Other control number
10.4199/C00135ED1V01Y201507NGL008
Other physical details
illustrations.
Reformatting quality
access
Specific material designation
remote
System details
System requirements: Adobe Acrobat reader

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