The Resource Crucial role for astrocytes in epilepsy, Peter Bedner and Christian Steinhäuser, (electronic book)
Crucial role for astrocytes in epilepsy, Peter Bedner and Christian Steinhäuser, (electronic book)
Resource Information
The item Crucial role for astrocytes in epilepsy, Peter Bedner and Christian Steinhäuser, (electronic book) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Sydney Jones Library, University of Liverpool.This item is available to borrow from 1 library branch.
Resource Information
The item Crucial role for astrocytes in epilepsy, Peter Bedner and Christian Steinhäuser, (electronic book) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Sydney Jones Library, University of Liverpool.
This item is available to borrow from 1 library branch.
- Summary
- This book summarizes current evidence of astrocyte dysfunction in epilepsy and discusses presumed underlying mechanisms. Epilepsy is characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizures in about one third of patients. Thus, there is an urgent need for new therapies that prevent generation of the disorder and improve seizure control in individuals already afflicted. The vast majority of epileptic cases are of idiopathic origin with their underlying mechanisms being unclear. Neurosurgical specimens from patients presenting with mesial temporal lobe epilepsy (MTLE) demonstrate marked reactive gliosis. Since recent studies have implicated astrocytes in important physiological roles in the CNS, such as synchronization of neuronal firing, it is plausible that they may also have a role in seizure generation and/or seizure spread. In support of this view, various membrane channels, receptors, and transporters in astrocytic membranes are altered in the epileptic brain. Excitingly, recent evidence suggests that in the course of the pathogenesis of MTLE, these glial changes alter homeostatic network functions and temporally precede the alterations in neurons. These findings might eventually classify MTLE as a glial rather than a neuronal disorder, and identify astrocytes as promising new targets for the development of more specific antiepileptogenic therapeutic strategies. Although research on astrocytes in epilepsy is still in its infancy, this book clearly demonstrates a critical role of astrocytes in the disturbance of K+ and transmitter homeostasis and its impact on seizure generation
- Language
- eng
- Extent
- 1 PDF (ix, 79 pages)
- Contents
-
- 1. Introduction --
- 2. K+ buffering in epilepsy -- 2.1 K+ uptake and spatial buffering -- 2.2 Kir4.1 channels and K+ buffering in epilepsy --
- 3. GJ communication in epilepsy -- 3.1 GJ coupling of astrocytes -- 3.2 Potential roles of GJs in epilepsy -- 3.3 Connexin expression and coupling in epileptic tissue -- 3.4 Role of Cx hemichannels and pannexin channels in epilepsy --
- 4. Aquaporin-4 dysfunction and epilepsy -- 4.1 Astrocytes express aquaporin-4 -- 4.2 Role of aquaporin-4 in epilepsy -- 4.3 AQP4 expression and regulation in epileptic tissue --
- 5. Altered glutamate homeostasis in epilepsy -- 5.1 Astrocytes regulate the extracellular glutamate concentration -- 5.2 Extracellular glutamate levels and glutamate uptake in TLE -- 5.3 Regulation of GS in epilepsy --
- 6. Dysfunction of the BBB in epilepsy -- 6.1 Consequences of BBB opening for neuronal and astrocytic function -- 6.2 TGF[beta] receptor signaling in astrocytes and epileptogenesis --
- 7. Astrocyte Ca2+ signaling and gliotransmission in epilepsy -- 7.1 Ca2+ signaling -- 7.2 Glutamate release -- 7.3 Astrocyte release of ATP and epilepsy --
- 8. Adenosine dysfunction in epilepsy -- 8.1 Role of astrocyte-derived adenosine in epilepsy -- 8.2 Role of glial ADK in epilepsy --
- 9. Astrocyte immune responses and epilepsy -- 9.1 Astrocyte changes induced by brain inflammation -- 9.2 Involvement of astrocytes in brain inflammation --
- 10. Astrocytes and absence epilepsy --
- 11. Conclusions -- References -- Author biographies
- Isbn
- 9781615047154
- Label
- Crucial role for astrocytes in epilepsy
- Title
- Crucial role for astrocytes in epilepsy
- Statement of responsibility
- Peter Bedner and Christian Steinhäuser
- Language
- eng
- Summary
- This book summarizes current evidence of astrocyte dysfunction in epilepsy and discusses presumed underlying mechanisms. Epilepsy is characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizures in about one third of patients. Thus, there is an urgent need for new therapies that prevent generation of the disorder and improve seizure control in individuals already afflicted. The vast majority of epileptic cases are of idiopathic origin with their underlying mechanisms being unclear. Neurosurgical specimens from patients presenting with mesial temporal lobe epilepsy (MTLE) demonstrate marked reactive gliosis. Since recent studies have implicated astrocytes in important physiological roles in the CNS, such as synchronization of neuronal firing, it is plausible that they may also have a role in seizure generation and/or seizure spread. In support of this view, various membrane channels, receptors, and transporters in astrocytic membranes are altered in the epileptic brain. Excitingly, recent evidence suggests that in the course of the pathogenesis of MTLE, these glial changes alter homeostatic network functions and temporally precede the alterations in neurons. These findings might eventually classify MTLE as a glial rather than a neuronal disorder, and identify astrocytes as promising new targets for the development of more specific antiepileptogenic therapeutic strategies. Although research on astrocytes in epilepsy is still in its infancy, this book clearly demonstrates a critical role of astrocytes in the disturbance of K+ and transmitter homeostasis and its impact on seizure generation
- Cataloging source
- CaBNVSL
- http://library.link/vocab/creatorName
- Bedner, Peter
- Dewey number
- 616.853
- Illustrations
- illustrations
- Index
- no index present
- LC call number
- RC372
- LC item number
- .B433 2015
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- abstracts summaries
- bibliography
- http://library.link/vocab/relatedWorkOrContributorName
- Steinhäuser, Christian.
- Series statement
- Colloquium series on neuroglia in biology and medicine,
- Series volume
- 8
- http://library.link/vocab/subjectName
-
- Epilepsy
- Astrocytes
- Epilepsy
- Astrocytes
- Target audience
-
- adult
- specialized
- Label
- Crucial role for astrocytes in epilepsy, Peter Bedner and Christian Steinhäuser, (electronic book)
- Bibliography note
- Includes bibliographical references (pages 47-77)
- Carrier category
- online resource
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type MARC source
- rdacontent
- Contents
-
- 1. Introduction --
- 2. K+ buffering in epilepsy -- 2.1 K+ uptake and spatial buffering -- 2.2 Kir4.1 channels and K+ buffering in epilepsy --
- 3. GJ communication in epilepsy -- 3.1 GJ coupling of astrocytes -- 3.2 Potential roles of GJs in epilepsy -- 3.3 Connexin expression and coupling in epileptic tissue -- 3.4 Role of Cx hemichannels and pannexin channels in epilepsy --
- 4. Aquaporin-4 dysfunction and epilepsy -- 4.1 Astrocytes express aquaporin-4 -- 4.2 Role of aquaporin-4 in epilepsy -- 4.3 AQP4 expression and regulation in epileptic tissue --
- 5. Altered glutamate homeostasis in epilepsy -- 5.1 Astrocytes regulate the extracellular glutamate concentration -- 5.2 Extracellular glutamate levels and glutamate uptake in TLE -- 5.3 Regulation of GS in epilepsy --
- 6. Dysfunction of the BBB in epilepsy -- 6.1 Consequences of BBB opening for neuronal and astrocytic function -- 6.2 TGF[beta] receptor signaling in astrocytes and epileptogenesis --
- 7. Astrocyte Ca2+ signaling and gliotransmission in epilepsy -- 7.1 Ca2+ signaling -- 7.2 Glutamate release -- 7.3 Astrocyte release of ATP and epilepsy --
- 8. Adenosine dysfunction in epilepsy -- 8.1 Role of astrocyte-derived adenosine in epilepsy -- 8.2 Role of glial ADK in epilepsy --
- 9. Astrocyte immune responses and epilepsy -- 9.1 Astrocyte changes induced by brain inflammation -- 9.2 Involvement of astrocytes in brain inflammation --
- 10. Astrocytes and absence epilepsy --
- 11. Conclusions -- References -- Author biographies
- Control code
- 201507NGL008
- Dimensions
- unknown
- Extent
- 1 PDF (ix, 79 pages)
- File format
- multiple file formats
- Form of item
- online
- Isbn
- 9781615047154
- Media category
- electronic
- Media MARC source
- isbdmedia
- Other control number
- 10.4199/C00135ED1V01Y201507NGL008
- Other physical details
- illustrations.
- Reformatting quality
- access
- Specific material designation
- remote
- System details
- System requirements: Adobe Acrobat reader
- Label
- Crucial role for astrocytes in epilepsy, Peter Bedner and Christian Steinhäuser, (electronic book)
- Bibliography note
- Includes bibliographical references (pages 47-77)
- Carrier category
- online resource
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type MARC source
- rdacontent
- Contents
-
- 1. Introduction --
- 2. K+ buffering in epilepsy -- 2.1 K+ uptake and spatial buffering -- 2.2 Kir4.1 channels and K+ buffering in epilepsy --
- 3. GJ communication in epilepsy -- 3.1 GJ coupling of astrocytes -- 3.2 Potential roles of GJs in epilepsy -- 3.3 Connexin expression and coupling in epileptic tissue -- 3.4 Role of Cx hemichannels and pannexin channels in epilepsy --
- 4. Aquaporin-4 dysfunction and epilepsy -- 4.1 Astrocytes express aquaporin-4 -- 4.2 Role of aquaporin-4 in epilepsy -- 4.3 AQP4 expression and regulation in epileptic tissue --
- 5. Altered glutamate homeostasis in epilepsy -- 5.1 Astrocytes regulate the extracellular glutamate concentration -- 5.2 Extracellular glutamate levels and glutamate uptake in TLE -- 5.3 Regulation of GS in epilepsy --
- 6. Dysfunction of the BBB in epilepsy -- 6.1 Consequences of BBB opening for neuronal and astrocytic function -- 6.2 TGF[beta] receptor signaling in astrocytes and epileptogenesis --
- 7. Astrocyte Ca2+ signaling and gliotransmission in epilepsy -- 7.1 Ca2+ signaling -- 7.2 Glutamate release -- 7.3 Astrocyte release of ATP and epilepsy --
- 8. Adenosine dysfunction in epilepsy -- 8.1 Role of astrocyte-derived adenosine in epilepsy -- 8.2 Role of glial ADK in epilepsy --
- 9. Astrocyte immune responses and epilepsy -- 9.1 Astrocyte changes induced by brain inflammation -- 9.2 Involvement of astrocytes in brain inflammation --
- 10. Astrocytes and absence epilepsy --
- 11. Conclusions -- References -- Author biographies
- Control code
- 201507NGL008
- Dimensions
- unknown
- Extent
- 1 PDF (ix, 79 pages)
- File format
- multiple file formats
- Form of item
- online
- Isbn
- 9781615047154
- Media category
- electronic
- Media MARC source
- isbdmedia
- Other control number
- 10.4199/C00135ED1V01Y201507NGL008
- Other physical details
- illustrations.
- Reformatting quality
- access
- Specific material designation
- remote
- System details
- System requirements: Adobe Acrobat reader
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.liverpool.ac.uk/portal/Crucial-role-for-astrocytes-in-epilepsy-Peter/rfHC-yuZz04/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.liverpool.ac.uk/portal/Crucial-role-for-astrocytes-in-epilepsy-Peter/rfHC-yuZz04/">Crucial role for astrocytes in epilepsy, Peter Bedner and Christian Steinhäuser, (electronic book)</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.liverpool.ac.uk/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.liverpool.ac.uk/">Sydney Jones Library, University of Liverpool</a></span></span></span></span></div>
